Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides [PDF]
Molecules, 2007 This paper presents a review on kaurane diterpenes and their glycoside derivatives, covering aspects of their occurrence, biological activities and the synthesis of these natural products and their analogues. First, it shows and classifies diterpenes, in
Ronan Batista +1 more
exaly +4 more sources
Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli [PDF]
Beilstein Journal of Organic Chemistry, 2022 The clerodane and ent-kaurane diterpenoids are two typical categories of diterpenoid natural products with complicated polycyclic carbon skeletons and significant pharmacological activities. Despite exciting advances in organic chemistry, access to these
Fang-Ru Li +4 more
doaj +2 more sources
Methoxylated Flavonols and ent-Kaurane Diterpenes from the South African Helichrysum rutilans and Their Cosmetic Potential [PDF]
Plants, 2023 Chromatographic fractionation of a methanol extract of Helichrysum rutilans afforded seven known compounds. The isolated compounds were identified as 5,7,8-trihydroxy-3,6-dimethoxyflavone-8-O-2-methyl-2-butanoate (C-1), 5,7-dihydroxy-3,6,8 ...
Olugbenga K. Popoola +3 more
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The Remarkable Structural Diversity Achieved in ent-Kaurane Diterpenes by Fungal Biotransformations [PDF]
Molecules, 2014 The use of biotransformations in organic chemistry is widespread, with highlights of interesting applications in the functionalization of natural products containing unactivated carbons, like the kaurane diterpenes.
Jacqueline A. Takahashi +4 more
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Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes [PDF]
Biomolecules, 2020 Since the first discovery in 1961, more than 1300 ent-kaurane diterpenoids have been isolated and identified from different plant sources, mainly the genus Isodon. Chemically, they consist of a perhydrophenanthrene subunit and a cyclopentane ring.
Md. Shahid Sarwar +4 more
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Three New Cytotoxic ent-Kaurane Diterpenes from Isodon excisoides [PDF]
Molecules, 2015 Three types of ent-kaurane diterpenoids were isolated from the aerial parts of Isodon excisoides, including three new diterpenoids, 1α,7α,14β-trihydroxy-20-acetoxy-ent-kaur-15-one (1); 1α,7α,14β,18-tetrahydroxy-20-acetoxy-ent-kaur-15-one (2); and 1α ...
Li-Ping Dai +6 more
doaj +2 more sources
ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity [PDF]
Molecules, 2016 Aldama discolor (syn.Viguiera discolor) is an endemic Asteraceae from the Brazilian “Cerrado”, which has not previously been investigated for its chemical constituents and biological activity.
Mauro S. Nogueira +4 more
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Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase PfATP6 [PDF]
Memorias do Instituto Oswaldo Cruz, 2015 Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though
Daniel Silqueira Martins Guimarães +6 more
doaj +2 more sources
Ent-Kaurane Diterpenoids from Coffea Genus: An Update of Chemical Diversity and Biological Aspects [PDF]
MoleculesCoffee is one of the most important beverages in the world and is produced from Coffea spp. beans. Diterpenes with ent-kaurane backbones have been described in this genus, and substances such as cafestol and kahweol have been widely investigated, along ...
Víctor de C. Martins +4 more
doaj +2 more sources
Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis [PDF]
MoleculesThree novel ent-kaurane diterpenes, namely sigesbeckin A–C (1–3), in conjunction with eight previously identified analogues (4–11), were isolated from Sigesbeckia orientalis. Their chemical structures were resolved through multiple spectroscopic analyses.
Zhong-Shun Zhou +6 more
doaj +2 more sources