Results 11 to 20 of about 20,581 (189)

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I [PDF]

Molecules, 2021
The current treatments against Leishmania parasites present high toxicity and multiple side effects, which makes the control and elimination of leishmaniasis challenging.
Chonny Herrera-Acevedo, Areli Flores-Gaspar, Luciana Scotti, Francisco Jaime Bezerra Mendonça-Junior, Marcus Tullius Scotti, Ericsson Coy-Barrera   +5 more
doaj   +4 more sources

Trachylobane and kaurane diterpenes from Croton floribundus spreng [PDF]

Química Nova, 2013
A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur ...
Paula Karina S. Uchôa, José Nunes da Silva Jr., Edilberto Rocha Silveira, Mary Anne S. Lima, Raimundo Braz-Filho, Letícia Veras Costa-Lotufo, Ana Jérsia Araújo, Manoel Odorico de Moraes, Claudia do Ó Pessoa   +8 more
doaj   +4 more sources

Bioactive Ent-Kaurane Diterpenes Oridonin and Irudonin Prevent Cancer Cells Migration by Interacting with the Actin Cytoskeleton Controller Ezrin. [PDF]

Int J Mol Sci, 2020
The ent-kaurane diterpene oridonin was reported to inhibit cell migration and invasion in several experimental models. However, the process by which this molecule exerts its anti-metastatic action has not been yet elucidated.
Pagliara V, Donadio G, De Tommasi N, Amodio G, Remondelli P, Moltedo O, Dal Piaz F.   +6 more
europepmc   +2 more sources

Antiproliferative Activity Of Flavonoids From Croton Sphaerogynus Baill. (euphorbiaceae). [PDF]

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Croton sphaerogynus is a shrub from the Atlantic Rain Forest in southeastern Brazil. A lyophilized crude EtOH extract from leaves of C. sphaerogynus, obtained by maceration at room temperature (seven days), was suspended in methanol and partitioned with ...
de Carvalho, João E, dos Santos, Kátia Pereira, Ferreira, Marcelo J Pena, Furlan, Cláudia M, Lago, João Henrique G, Motta, Lucimar B, Ruiz, Ana Lúcia T G, Salatino, Antonio, Salatino, Maria L F, Santos, Deborah Y A C   +9 more
core   +10 more sources

Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae) [PDF]

Química Nova, 2012
Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-
Dayanne Meneses Silva, Emmanoel Vilaça Costa, Paulo Cesar de Lima Nogueira, Valéria Regina de Souza Moraes, Sócrates Cabral de Holanda Cavalcanti, Marcos José Salvador, Luis Henrique Gonzaga Ribeiro, Fernanda Ramos Gadelha, Andersson Barison, Antonio Gilberto Ferreira   +9 more
doaj   +6 more sources

Four New ent-Kaurane Diterpene Glycosides from Isodon henryi [PDF]

Molecules, 2019
To obtain diterpene glycosides from an aqueous extract of the aerial parts of Isodon henryi and further investigate their cytotoxicities, in this study, a total of seven compounds were isolated, including six ent-kaurane diterpene glycosides (1−6 ...
Ya-Lin Liu, Ling-Xia Zhang, Hong Wu, Sui-Qing Chen, Jun Li, Li-Ping Dai, Zhi-Min Wang   +6 more
doaj   +3 more sources

Cafestol-derivatives as potential FXR agonists and CYP7A1 inhibitors and their impact on hypercholesterolemia: an in silico study [PDF]

Scientific Reports
Cafestol is a hypercholesterolemic ent-kaurane diterpene found in unfiltered coffee, a regular component of the human diet. This diterpene is reported to modulate macromolecules involved in cholesterol metabolism, such as the farnesoid X receptor (FXR ...
Maria Alice Esteves da Silva, Priscila Goes Camargo, Camilo Henrique da Silva Lima, Carlos Rangel Rodrigues, Magaly Girão Albuquerque, Claudia Moraes de Rezende   +5 more
doaj   +2 more sources

Five new ent-kaurane diterpenes from Annona squamosa L. pericarps

Natural Product Research, 2019
In the present study, five new ent-kaurane diterpenes including 4α-hydroxy-17,19-dinor-ent-kaurane-16-one (1), 4β-hydroxy-16β-H-18-nor-ent-kaurane-17-oic acid (2), 4β,17-dihydroxy-16α-acetoxy-18-nor-ent-kaurane (3), Annosquamosin Z (4) and 16α-H-ent ...
Ya-yun Chen, Chengyao Ma, Maolin Wang, Jianying Lu, Peng Hu, Jian-wei Chen, Xiang Li, Yong Chen   +7 more
semanticscholar   +3 more sources

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others [PDF]

Natural Products and Bioprospecting
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara.
Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu   +11 more
doaj   +2 more sources

Synthetic Derivatives of Natural ent-Kaurane Atractyligenin Disclose Anticancer Properties in Colon Cancer Cells, Triggering Apoptotic Cell Demise. [PDF]

Int J Mol Sci
The antitumor activity of different ent-kaurane diterpenes has been extensively studied. Several investigations have demonstrated the excellent antitumor activity of synthetic derivatives of the diterpene atractyligenin. In this research, a series of new
Badalamenti N, Maggio A, Fontana G, Bruno M, Lauricella M, D'Anneo A.   +5 more
europepmc   +2 more sources