Results 21 to 30 of about 1,570 (164)

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

Medicinal Research Reviews, Volume 43, Issue 3, Page 614-682, May 2023., 2023
Abstract Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight cancer and overcome drug resistance in antitumor therapy. Understanding the molecular interactions and structural features of ferroptosis‐inducing compounds might ...
Solveigh C. Koeberle, Anna P. Kipp, Hermann Stuppner, Andreas Koeberle   +3 more
wiley   +1 more source

Risks for human health related to the presence of grayanotoxins in certain honey

EFSA Journal, Volume 21, Issue 3, March 2023., 2023
Abstract The European Commission asked EFSA for a scientific opinion on the risks for human health of the presence of grayanotoxins (GTXs) in ‘certain honey’ from Ericaceae plants. The risk assessment included all structurally related grayananes occurring with GTXs in ‘certain’ honey. Oral exposure is associated with acute intoxication in humans. Acute
EFSA Panel on Contaminants in the Food Chain (CONTAM), Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Birgit Dusemund, Andrew Hart, Patrick Mulder, Barbara Viviani, Maria Anastassiadou, Claudia Cascio, Francesca Riolo, Heather Wallace   +24 more
wiley   +1 more source

Labdane conjugates protect cardiomyocytes from doxorubicin‐induced cardiotoxicity

Drug Development Research, Volume 84, Issue 1, Page 84-95, February 2023., 2023
Abstract The cardiovascular side effects associated with doxorubicin (DOX), a wide spectrum anticancer drug, have limited its clinical application. Therefore, to explore novel strategies with cardioprotective effects, a series of new labdane conjugates were prepared (6a–6c and 8a–8d) from the natural diterpene labdanodiol (1).
Irene Cuadrado, Sandra Oramas‐Royo, Laura González‐Cofrade, Ángel Amesty, Sonsoles Hortelano, Ana Estévez‐Braun, Beatriz de las Heras   +6 more
wiley   +1 more source

Network‐Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA‐Transcriptome

Journal of Immunology Research, Volume 2023, Issue 1, 2023., 2023
The morbidity of oral cancer is high in the world. Oridonin is a traditional Chinese medicine that can effectively inhibit oral squamous cell carcinoma (OSCC) growth, but its mechanism remains unclear. Our previous data showed that oridonin inhibited CAL‐27 cell proliferation and promoted apoptosis.
Guohui Wu, Yusheng Guo, Yang Liu, Xiangsheng Cai, Tanggang Deng, Tianchu Pei, Long Huang, Kai Chen, Xuan Pan, Jian Song   +9 more
wiley   +1 more source

Safety of the proposed amendment of the specifications for enzymatically produced steviol glycosides (E 960c): Rebaudioside D produced via enzymatic bioconversion of purified stevia leaf extract

EFSA Journal, Volume 20, Issue 5, May 2022., 2022
Abstract The EFSA Panel on Food Additives and Flavourings (FAF Panel) provides a scientific opinion on the safety of a proposed amendment of the specifications of enzymatically produced steviol glycosides (E 960c) with respect to the inclusion of rebaudioside D produced via enzyme‐catalysed bioconversion of purified stevia leaf extract. Rebaudioside D (
EFSA FAF Panel (EFSA Panel on Food Additives and Flavourings), Maged Younes, Gabriele Aquilina, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Rainer Gürtler, Ursula Gundert‐Remy, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, José Manuel Barat Baviera, Gisela Degen, Lieve Herman, Jean‐Charles Leblanc, Detlef Wölfle, Jaime Aguilera, Alessandra Giarola, Camilla Smeraldi, Giorgia Vianello, Laurence Castle   +26 more
wiley   +1 more source

Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages. [PDF]

Br J Pharmacol, 2007
Background and purpose:The kaurane diterpenes foliol and linearol are inhibitors of the activation of nuclear factor κB, a transcription factor involved in the inflammatory response. Effects of these diterpenes on apoptosis and phagocytosis have been analysed in cultured peritoneal macrophages and in the mouse macrophage cell line, RAW 264.7 ...
de las Heras B, Hortelano S, Girón N, Bermejo P, Rodríguez B, Boscá L.   +5 more
europepmc   +7 more sources

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae)

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022
Croton gratissimus is an important plant in Africa setup and across the globe for its ethnomedicinal uses in managing a wide range of diseases. Its phylogeny, pharmacological properties, ethnomedicinal uses, phytochemistry, and cytotoxicity have been highlighted in various articles and journals.
Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara, Srinivas Mutalik   +4 more
wiley   +1 more source

Ethnomedicinal Information on Plants Used for the Treatment of Bone Fractures, Wounds, and Sprains in the Northern Region of the Republic of Benin

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Medicinal plants are frequently used in African countries due to their importance in the treatment of various conditions. In the northern Republic of Benin, traditional healers are recognized as specialists in the treatment of fractures, wounds, and sprains.
Nonvignon Murielle Codo Toafode, Emelia Oppong Bekoe, Zacharie Vissiennon, Virgile Ahyi, Cica Vissiennon, Karin Fester, Mohammed Bourhia   +6 more
wiley   +1 more source

Integrated Strategy of UHPLC‐Q‐TOF‐MS and Molecular Networking for Identification of Diterpenoids from Euphorbia fischeriana Steud. and Prediction of the Anti‐Breast‐Cancer Mechanism by the Network Pharmacological Method

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Breast cancer is one of the most common malignancies in women worldwide. Traditional Chinese medicine has been used as adjunctive or complementary therapy for breast cancer. Diterpenoids from Euphorbia fischeriana Steud. have been demonstrated to possess anti‐breast‐cancer activity.
Tian-Cheng Ma, Yu-Kun Ma, Jin-Ling Zhang, Lei Liu, Jia Sun, Li-Na Guo, Qi Liu, Yu Sun, Siti Fatimah Sabran   +8 more
wiley   +1 more source

One amino acid makes the difference: the formation of -kaurene and 16α-hydroxy-kaurane by diterpene synthases in poplar [PDF]

, 2015
BACKGROUND: Labdane-related diterpenoids form the largest group among the diterpenes. They fulfill important functions in primary metabolism as essential plant growth hormones and are known to function in secondary metabolism as, for example ...
Gershenzon, J., Günther, J., Irmisch, S., Köllner, T., Müller, A., Schmidt, L.   +5 more
core   +4 more sources