Results 141 to 150 of about 129,498 (304)

Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukaemia in the chronic phase: Result of the Japan Adult Leukemia Study Group RE‐STOP219 study

British Journal of Haematology, EarlyView.
Summary Treatment‐free remission (TFR) is now a key goal for chronic‐phase chronic myeloid leukaemia (CML‐CP) after achievement of a prolonged deep molecular response. About half of these patients can remain in remission without treatment, whereas those who relapse must resume lifelong therapy.
Noriyoshi Iriyama, Naoto Takahashi, Katsumichi Fujimaki, Takaaki Ono, Masuho Saburi, Masahide Yamamoto, Fumihiko Kimura, Eisei Kondo, Nobuyuki Aotsuka, Hiroki Yokoyama, Seiichiro Katagiri, Yosuke Minami, Maho Ishikawa, Yachiyo Kuwatsuka, Masatomo Miura, Akiko M. Saito, Toshiki I. Saito, Itaru Matsumura, Yasushi Miyazaki, Emiko Sakaida, Yoshinobu Maeda, Takahiro Yamauchi, Hitoshi Kiyoi   +22 more
wiley   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, EarlyView.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, EarlyView.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

Durability and Safety of Imeglimin as an Add‐On to DPP‐4 Inhibitors in Japanese Type 2 Diabetes: The 104‐Week FAMILIAR Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the long‐term efficacy and safety of imeglimin added to dipeptidyl peptidase‐4 (DPP‐4) inhibitors in Japanese patients with type 2 diabetes, focusing on glycemic durability and safety in elderly patients over 104 weeks. Materials and Methods This multicenter, randomized, placebo‐controlled trial comprised a 24‐week double ...
Masashi Shimoda, Takeshi Osonoi, Masahiro Iwamoto, Hideaki Kaneto, Kohei Kaku   +4 more
wiley   +1 more source

Family Size and Food Allergy in Early Childhood: The Japan Environment and Children's Study

Allergy, EarlyView.
Takayasu Nomura, Hisashi Tanida, Takeshi Inoue, Sayaka Kato, Daiki Hiraoka, Yuki Ito, Mayumi Sugiura‐Ogasawara, Shinji Saitoh, Michihiro Kamijima, Yukihiro Ohya, The Japan Environment and Children's Study (JECS) Group, Michihiro Kamijima, Shin Yamazaki, Maki Fukami, Reiko Kishi, Chiharu Ota, Koichi Hashimoto, Kenichi Sakurai, Shuichi Ito, Ryoji Shinohara, Hidekuni Inadera, Takeo Nakayama, Ryo Kawasaki, Yasuhiro Takeshima, Hideki Nagashima, Narufumi Suganuma, Mayumi Tsuji, Kimitoshi Nakamura   +27 more
wiley   +1 more source

Impact Absorption Power of Polyolefin Fused Filament Fabrication 3D‐Printed Sports Mouthguards: In Vitro Study

Dental Traumatology, Volume 41, Issue 2, Page 213-223, April 2025.
ABSTRACT Background/Aim This study aims to evaluate and compare the impact absorption capacities of thermoformed ethylene vinyl acetate (EVA) mouthguards and 3D‐printed polyolefin mouthguards used in sports dentistry applications. The objective is to determine whether 3D‐printed polyolefin mouthguards offer superior impact toughness compared to ...
Leonardo Mohamad Nassani, Samuel Storts, Irina Novopoltseva, Lauren Ann Place, Matthew Fogarty, Pete Schupska   +5 more
wiley   +1 more source

Birch Leaves as a Minefield: Do Trichomes Mediate Neonate Caterpillar Site Selection?

Entomologia Experimentalis et Applicata, EarlyView.
We investigated whether neonate Drepana arcuata caterpillars select leaf sites based on trichome distribution. Specifically, we assessed where larvae establish on leaves, quantified trichome distribution on leaves, and tested whether neonates avoid leaf trichomes. Neonates preferentially established and fed on areas with fewer trichomes, especially the
Leonardo M. Turchen, Jacob Dyck, Jayne E. Yack   +2 more
wiley   +1 more source

Utilizing T-Lymphocyte Activation-Related Cytokines to Predict Non-Responsiveness to Treatment in Pediatric Kawasaki Disease

Pediatric Health, Medicine and Therapeutics
Bei Ye,1 Jiying Xiao,2 Caiyun Zhang3 1Department of Pediatrics, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Respiratory Medicine, Hangzhou Children’s Hospital, Hangzhou, Zhejiang, People’s Republic of ...
Ye B, Xiao J, Zhang C
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