Results 11 to 20 of about 118,357 (315)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Vascular Function Long Term After Kawasaki Disease: Another Piece of the Puzzle? [PDF]

, 2017
BACKGROUND: Kawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies.
Gomes, I, Laranjo, S, Loureiro, P, Mota Carmo, M, Pinto, MF, Timóteo, AT   +5 more
core   +1 more source

Kawasaki disease shock syndrome complicated by coronary aneurysms: a case report

The Pan African Medical Journal, 2021
Kawasaki disease is a generalized systemic vasculitis, which primarily affects medium-sized arteries. Kawasaki disease shock syndrome is a rare but severe presentation of this disease. This report describes a case of delayed diagnosis of Kawasaki disease
Ahmed Rassas, Rihab Guizani, Amina Werdani, Nesrine Jammeli, Bahri Mahjoub   +4 more
doaj   +1 more source

Intestinal Involvement in Kawasaki Disease [PDF]

, 2018
To describe a case of Kawasaki disease with intestinal involvement and to analyze other published reports to define clinical characteristics, diagnostic issues, and therapeutic approaches of gastrointestinal involvement in Kawasaki ...
Cascio, Antonio, Ciccia, Francesco, Colomba, Claudia, Corsello, Giovanni, Di Carlo, Paola, La Placa, Simona, MEDAGLIA, Alice Annalisa, Romanin, Benedetta, Saporito, Laura, Serra, Nicola   +9 more
core   +1 more source

Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin [PDF]

, 2020
Importance: Timely initiation of intravenous immunoglobulin plus aspirin is necessary for decreasing the risk of recrudescent fever and coronary artery abnormalities in children with Kawasaki disease (KD). The optimal dose of aspirin, however, remains
Belarski, Emily, Carroll, Aaron E., John, Chandy C., Manaloor, John, Ofner, Susan, Platt, Brooks, Wood, James B.   +6 more
core   +1 more source

An Analysis of Risk Factors for Developing Hepatocellular Carcinoma in a Group of Hepatitis C Patients with Stage 3 Fibrosis following Interferon Therapy

Cancer Informatics, 2008
The risk of Hepatocellular carcinoma (HCC) is high in HCV-infected patients who have biochemically and histologically active chronic hepatitis. To observe the long prognosis of Chronic Hepatitis C (CHC) patients with stage 3 fibrosis (F3), 55 CHC ...
Sabina Mahmood, Kazumi Togawa, Miwa Kawanaka, Gouichi Niiyama, Gotaro Yamada   +4 more
doaj   +1 more source

Kawasaki disease in Iceland 1996-2005, epidemiology and complications [PDF]

, 2012
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Allur texti - Full textOBJECTIVE: To analyze the epidemiology of Kawasaki disease in Icelandic children and its complications.
Gylfi Óskarsson, Halla Sif Ólafsdóttir, Ásgeir Haraldsson   +2 more
core   +1 more source

Very early onset of coronary artery aneurysm in a 3-month infant with Kawasaki disease: a case report and literature review

Italian Journal of Pediatrics, 2023
Background Kawasaki disease (KD) is a medium vessel vasculitis, of unknown etiology, typically presenting in children younger than 5 years of age. Prolonged fever (at least five days) is a major clinical criterion of KD, while cardiac involvement may ...
Wenyan Jiao, Li Wei, Fuyong Jiao, Dorina Pjetraj, Jianying Feng, Jvyan Wang, Carlo Catassi, Simona Gatti   +7 more
doaj   +1 more source

Kawasaki Disease

Acta Paediatrica, 1991
SummaryIn this review, I have outlined the clinical picture, epidemiology, pathology, etiology, and current treatment and management of Kawasaki disease. The disease in question has unique features which cannot be classified into any of the categories of conventional pediatric diseases, and thus the elucidation of the etiology and mode of onset may ...
openaire   +8 more sources