Results 11 to 20 of about 36,113 (205)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Activin a suppresses peripheral CD8+ T lymphocyte activity in acute-phase Kawasaki disease

BMC Immunology, 2021
Background Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old.
Qian Wu, Ruohang Weng, Yongbin Xu, Linlin Wang, Yanyan Huang, Jun Yang   +5 more
doaj   +1 more source

Calculating the fraction of Kawasaki disease potentially attributable to seasonal pathogens: a time series analysisResearch in context

EClinicalMedicine, 2023
Summary: Background: Kawasaki disease is an acute, febrile, systemic vasculitis of children that primarily affects medium-sized blood vessels with a tropism for the coronary arteries. Although the etiological factors remain unknown, infections have been
Zaba Valtuille, Alain Lefevre-Utile, Naim Ouldali, Constance Beyler, Priscilla Boizeau, Cécile Dumaine, Arthur Felix, Zein Assad, Albert Faye, Isabelle Melki, Florentia Kaguelidou, Ulrich Meinzer   +11 more
doaj   +1 more source

Hemophagocytosis in the Acute Phase of Fatal Kawasaki Disease in a 4 Month-Old Girl

Balkan Medical Journal, 2016
Background: Kawasaki disease is a systemic vasculitis predominately affecting coronary arteries. Hemophagocytic lymphohistiocytosis can complicate the course of Kawasaki disease.
Vehbi Doğan, Erhan Karaaslan, Samet Özer, Rüveyda Gümüşer, Resul Yılmaz   +4 more
doaj   +1 more source

Landscape of intestinal microbiota in patients with IgA nephropathy, IgA vasculitis and Kawasaki disease

Frontiers in Cellular and Infection Microbiology, 2022
ObjectiveTo explore the common differential flora of IgAN, Kawasaki disease and IgA vasculitis by screening and analyzing the differential intestinal flora between the three disease groups of IgAN, Kawasaki disease and IgA vasculitis and their healthy ...
Xueli Hu, Ru Fan, Wenzhu Song, Jianbo Qing, Xiaoyan Yan, Yaheng Li, Qi Duan, Yafeng Li, Yafeng Li, Yafeng Li, Yafeng Li   +10 more
doaj   +1 more source

Lymphadenitis and Fever: First Presentation of Kawasaki Disease

Journal of Pediatric Research, 2017
Kawasaki disease is a vasculitis of infant and childhood period. Diagnosis of Kawasaki disease is based on clinical criteria including cervical lymphadenopathy.
Şule Gökçe, Pelin Elibol, Güldane Koturoğlu, Yasemin Özdemir Şahan, Zülal Ülger Tutar   +4 more
doaj   +1 more source

Atypical Kawasaki Disease in a 4 Years Old Child with Mumps

Journal of Nepal Medical Association, 2018
Kawasaki disease is an acute febrile condition seen in children. However, it is also well recognized that some patients do not fulfill the classic diagnostic criteria for the diagnosis of Kawasaki disease.
Prakash Banjade, Karan Subedi
doaj   +1 more source

Prognostic significance of low hepatic fat content in advanced chronic liver disease: MRI-PDFF insights

Annals of Hepatology
Introduction and Objectives: The mechanisms of hepatic fat loss in late-stage metabolic dysfunction-associated fatty liver disease (MASLD) are enigmatic and the prognostic significance of low hepatic fat content (LHF) in chronic liver disease (CLD) is ...
Atsushi Nakamura, Tsubasa Yoshimura, Takeshi Ichikawa, Keiji Okuyama   +3 more
doaj   +1 more source

Coronary artery lesions in children with Kawasaki disease: status quo and nursing care

Frontiers in Cardiovascular Medicine
AimCoronary artery lesion (CAL) is a common yet serious complication in children with Kawasaki disease. The aim of the present study was to evaluate the influencing factors of CAL in children with Kawasaki disease, to provide reference for the clinical ...
Cen Chen, Qiuhui Chen, Tong Zhang, Yanping Ling   +3 more
doaj   +1 more source