Results 21 to 30 of about 36,113 (205)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Kawasaki Disease Complicated by Salmonella oranienburg Coinfection

Case Reports in Pediatrics, 2021
Kawasaki disease is a medium vessel vasculitis with a multisystem presentation affecting 9–20 per 100,000 children under 5 years of age in the United States. Salmonella coinfection has not been previously described.
Zachary Barbara, Savannah P. Ellenwood, Emily D. Loe, Joon Choi, Kathleen Ryan, Nancy Joseph   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

MIS-C Like Features in a Patient of Atypical Kawasaki Disease: A Case Report

Journal of Nepal Medical Association
Kawasaki Disease is multisystem vasculitis affecting young children and infants. While the diagnosis of a typical form of Kawasaki Disease is obvious, there are some patients who do not fulfill the classic diagnostic criteria for the disease which is ...
Anisha Karki, Abhishek Jha, Shova Sapkota, Nikita Kashyap, Sunil Raja Manandhar   +4 more
doaj   +1 more source

A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses

BMC Medicine, 2011
Background Kawasaki disease is an acute vasculitis of infants and young children that is recognized through a constellation of clinical signs that can mimic other benign conditions of childhood.
Ling Xuefeng B, Lau Kenneth, Kanegaye John T, Pan Zheng, Peng Sihua, Ji Jun, Liu Gigi, Sato Yuichiro, Yu Tom TS, Whitin John C, Schilling James, Burns Jane C, Cohen Harvey J   +12 more
doaj   +1 more source

Exploring the Therapeutic Potential of Vitamin D in Kawasaki Disease and Its Interplay with the COVID-19

Turkish Archives of Pediatrics
Objective: Several studies have reported outbreaks of Kawasaki disease among children amid the coronavirus disease 2019 (COVID-19) pandemic. Vitamin D possesses high utility in modulating the immune system to repair and prevent severe inflammation in ...
Visuddho Visuddho, Yongki Welliam, Fan Maitri Aldian, Mahendra Tri Arif Sampurna, Abyan Irzaldy   +4 more
doaj   +1 more source

Primary Tumor Resection in Patients With Unresectable Metastatic Colorectal Cancer: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
This systematic review and meta‐analysis evaluated the role of primary tumor resection (PTR) in asymptomatic patients with unresectable metastatic colorectal cancer. Across 17 eligible studies including 9317 patients, PTR did not improve overall or progression‐free survival compared with chemotherapy alone.
Junpei Takashima, Hirotoshi Kobayashi, Daisuke Fujimoto, Fumihiko Miura   +3 more
wiley   +1 more source

Reappraisal of Real‐World Management of Acute Cholecystitis in Elderly Patients Based on the Adherence to Tokyo Guidelines 2018 (TG18): A Multicenter Study on Anzu HPB Surgical Meeting

Annals of Gastroenterological Surgery, EarlyView.
This multicenter retrospective study analyzes real‐world management of acute cholecystitis in patients aged ≥ 70 years across five institutions, focusing on adherence and intentional deviation from TG18 recommendations. By classifying treatment strategies as TG18‐accordant, more aggressive, or more conservative, we reappraise current practice patterns.
Yuta Kobayashi, Shojiro Hata, Ryo Oikawa, Tetsuya Nakazato, Hiroki Sakata, Hirokazu Yamaguchi, Yutaka Suzuki, Yoshihiro Sakamoto   +7 more
wiley   +1 more source

Contemporary Regional Disparities in Robotic‐Assisted Rectal Resection in Japan: A Nationwide Population‐Based Study Using the National Database Open Data

Annals of Gastroenterological Surgery, EarlyView.
Robotic‐assisted rectal resection in Japan increased markedly after national insurance reimbursement in 2018, with a concurrent decline in open surgery. Using NDB Open Data, we found substantial inter‐prefectural heterogeneity in surgical volume and robotic utilization that persisted after age and sex standardization (SCR). Urban–rural differences were
Ryo Ohta, Takeshi Yamada, Key Uehara, Hiromichi Sonoda, Akihisa Matsuda, Seiichi Shinji, Yasuyuki Yokoyama, Goro Takahashi, Nobuhiko Taniai, Hiroshi Yoshida   +9 more
wiley   +1 more source