Results 111 to 120 of about 10,273 (224)

G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling [PDF]

, 2015
Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths
Dolatshad, NF, Foldes, G, Harding, SE, Hellen, N, Jabbour, R   +4 more
core   +1 more source

Regulation of Kv11.1 Potassium Channel C-Terminal Isoform Expression by the RNA-Binding Proteins HuR and HuD

, 2018
The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart.
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core  

Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study [PDF]

, 2007
BACKGROUND: Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac arrhythmias.
Guo, Chao-Yu, Larson, Martin G., Levy, Daniel, Newton-Cheh, Christopher, O'Donnell, Christopher J., Wang, Thomas J.   +5 more
core   +4 more sources

Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China [PDF]

, 2014
BACKGROUND: Individual response to medications varies significantly among different populations, and great progress in understanding the molecular basis of drug action has been made in the past 50 years.
Chao Chen, Hong Wang, Jiayi Zhang, Tianbo Jin, Tingting Geng, Xiaolan Li, Yali Cui, Zulfiya Yunus   +7 more
core   +1 more source

Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance [PDF]

, 2022
Jaël S. Copier, Marianne Bootsma, Chai‐Ann Ng, Arthur A.M. Wilde, Robin A. Bertels, Hennie Bikker, Imke Christiaans, Saskia N. van der Crabben, Janna A. Hol, Tamara T. Koopmann, Jeroen Knijnenburg, Aafke A J Lommerse, Jasper J. van der Smagt, Connie R. Bezzina, Jamie I. Vandenberg, Arie O. Verkerk, Daniela Q.C.M. Barge‐Schaapveld, Elisabeth M. Lodder   +17 more
openalex   +3 more sources

Novel calmodulin mutations associated with congenital arrhythmia susceptibility. [PDF]

, 2014
BACKGROUND: Genetic predisposition to life-threatening cardiac arrhythmias such as congenital long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) represent treatable causes of sudden cardiac death in young adults and ...
Aiba, T., Beckmann, B.M., Behr, E.R., Bhuiyan, Z.A., Chazin, W.J., Crotti, L., Denjoy, I., Endo, N., George, A.L., Guicheney, P., Homfray, T., Ishikawa, T., Johnson, C.N., Kimura, A., Klug, D., Kääb, S., Lichtner, P., Makita, N., Mastantuono, E., Meitinger, T., Miyamoto, Y., Motomura, H., Nakagawa, H., Ozaki, K., Roh, M.S., Satake, W., Schwartz, P.J., Shigemizu, D., Shimizu, W., Suda, K., Tanaka, T., Theisen, D., Toda, T., Tsuchiya, T., Tsuji, Y., Tsunoda, T., Watanabe, H., Yagihara, N., Yamamoto, H.   +38 more
core   +1 more source

Aborted Cardiac Arrest in LQT2 Related to Novel KCNH2 (hERG) Variant Identified in One Lithuanian Family [PDF]

, 2021
Neringa Bileišienė, Jūratė Barysienė, Violeta Mikštienė, Eglė Preikšaitienė, Germanas Marinskis, Monika Keževičiūtė, Algirdas Utkus, Audrius Aidietis   +7 more
openalex   +1 more source

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channelKCNH2: Deep mutational scan ofKCNH2trafficking [PDF]

, 2020
Krystian A. Kozek, Andrew M. Glazer, Chai Ann Ng, Daniel Blackwell, Christian L Egly, Loren R. Vanags, Marcia Blair, Devyn Mitchell, Kenneth A. Matreyek, Douglas M. Fowler, Bjorn C. Knollmann, Jamie Vandenberg, Dan M. Roden, Brett M. Kroncke, Krystian A. Kozek, Andrew M. Glazer, Chai Ann Ng, Daniel Blackwell, Christian L Egly, Loren R. Vanags, Marcia Blair, Devyn Mitchell, Kenneth A. Matreyek, Douglas M. Fowler, Bjorn C. Knollmann, Jamie Vandenberg, Dan M. Roden, Brett M. Kroncke   +27 more
openalex   +1 more source

Investigação de variantes gênicas de canais iônicos em pacientes com síndrome do QT longo Investigación de variantes génicas de canales iónicos en pacientes con síndrome del QT largo Investigation of ion channel gene variants in patients with long QT syndrome

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: A síndrome do QT longo (SQTL) é uma síndrome arrítmica herdada com aumento do intervalo QT e risco de morte súbita. Mutações nos genes KCNQ1, KCNH2 e SCN5A respondem por 90% dos casos com genótipo determinado, e a genotipagem é informativa ...
Ernesto Curty, Fernando Eugênio dos Santos Cruz, Fabiane Santos Lima, Jorge Luiz Albuquerque Coutinho, Rosane Silva, Turán Peter Ürményi, Antônio Carlos Campos Carvalho, Edson Rondinelli   +7 more
doaj  

Selective acquired long QT syndrome (saLQTS) upon risperidone treatment

BMC Psychiatry, 2012
Background Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel.
Lazarczyk Maciej, Bhuiyan Zahir A, Perrin Nicolas, Giannakopoulos Panteleimon   +3 more
doaj   +1 more source