Results 111 to 120 of about 9,256 (240)

ECG-Based Measurements of Drug-induced Repolarization Changes [PDF]

, 2015
The purpose of this thesis is to investigate the abnormal repolarization both in the cellular and the surface ECG along with their relationship. It has been identified that the certain morphological changes of the monophasic action potential are ...
Bhuiyan, Tanveer Ahmed
core   +2 more sources

KCNH2 pharmacogenomics summary [PDF]

Pharmacogenetics and Genomics, 2010
Connie, Oshiro, Caroline F, Thorn, Dan M, Roden, Teri E, Klein, Russ B, Altman   +4 more
openaire   +2 more sources

Analysis of CACNA1C and KCNH2 Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia [PDF]

, 2022
Alexander Refisch, Shoko Komatsuzaki, Martin Ungelenk, Andy Schumann, Ha‐Yeun Chung, Susann S. Schilling, Wibke Jantzen, Sabine Schröder, Markus M. Nöthen, Thomas W. Mühleisen, Christian A. Hübner, Karl‐Jürgen Bär   +11 more
openalex   +1 more source

Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China [PDF]

, 2014
BACKGROUND: Individual response to medications varies significantly among different populations, and great progress in understanding the molecular basis of drug action has been made in the past 50 years.
Chao Chen, Hong Wang, Jiayi Zhang, Tianbo Jin, Tingting Geng, Xiaolan Li, Yali Cui, Zulfiya Yunus   +7 more
core   +1 more source

Novel calmodulin mutations associated with congenital arrhythmia susceptibility. [PDF]

, 2014
BACKGROUND: Genetic predisposition to life-threatening cardiac arrhythmias such as congenital long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) represent treatable causes of sudden cardiac death in young adults and ...
Aiba, T., Beckmann, B.M., Behr, E.R., Bhuiyan, Z.A., Chazin, W.J., Crotti, L., Denjoy, I., Endo, N., George, A.L., Guicheney, P., Homfray, T., Ishikawa, T., Johnson, C.N., Kimura, A., Klug, D., Kääb, S., Lichtner, P., Makita, N., Mastantuono, E., Meitinger, T., Miyamoto, Y., Motomura, H., Nakagawa, H., Ozaki, K., Roh, M.S., Satake, W., Schwartz, P.J., Shigemizu, D., Shimizu, W., Suda, K., Tanaka, T., Theisen, D., Toda, T., Tsuchiya, T., Tsuji, Y., Tsunoda, T., Watanabe, H., Yagihara, N., Yamamoto, H.   +38 more
core   +1 more source

Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies [PDF]

, 2012
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...
Arking, Dan E., Asselbergs, Folkert W., Brown, Morris, Carter, Nicholas D., Caulfield, Mark, Connell, John, Dalageorgou, Chrysoula, de Bakker, Paul I Wen, Deloukas, Panos, Dominiczak, Anna, Eijgelsheim, Mark, Farrall, Martin, Fu, Jingyuan, Gwilliam, Rhian, Jamshidi, Yalda, Jeffery, Steve, Lathrop, Mark, Munroe, Patricia B., Newhouse, Stephen J., Newton-Cheh, Christopher Holmes, Nolte, Ilja M., Paterson, Andrew D., Pfeufer, Arne, Rice, Kenneth Robert, Samani, Nilesh J., Sanna, Serena, Savelieva, Irina, Snieder, Harold, Soranzo, Nicole, Spector, Tim D., Tobin, Martin, Waggott, Daryl, Wain, Louise V., Wallace, Chris, Zeggini, Eleftheria, Zheng, Dongling   +35 more
core   +1 more source

Investigação de variantes gênicas de canais iônicos em pacientes com síndrome do QT longo Investigación de variantes génicas de canales iónicos en pacientes con síndrome del QT largo Investigation of ion channel gene variants in patients with long QT syndrome

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: A síndrome do QT longo (SQTL) é uma síndrome arrítmica herdada com aumento do intervalo QT e risco de morte súbita. Mutações nos genes KCNQ1, KCNH2 e SCN5A respondem por 90% dos casos com genótipo determinado, e a genotipagem é informativa ...
Ernesto Curty, Fernando Eugênio dos Santos Cruz, Fabiane Santos Lima, Jorge Luiz Albuquerque Coutinho, Rosane Silva, Turán Peter Ürményi, Antônio Carlos Campos Carvalho, Edson Rondinelli   +7 more
doaj  

Sinus Bradycardia and Long QT Syndrome: Double Heterozygosity for Variants in KCNH2 and HCN4

Cardiogenetics
Introduction: Clinical variability within families harbouring disease-causing genetic variants hampers clinical care and risk stratification. We studied a multigenerational family presenting with sinus bradycardia and long QT syndrome type 2 (LQTS2). The
Jaël S. Copier, Fenna Tuijnenburg, Karolina Andrzejczyk, Alex V. Postma, Saskia N. van der Crabben, Oussama Najih, Caroline Pham, Leander Beekman, Arie O. Verkerk, Ahmad S. Amin, Elisabeth M. Lodder   +10 more
doaj   +1 more source

The role of genetic testing in unexplained sudden death. [PDF]

, 2015
Most sudden deaths are because of a cardiac etiology and are termed sudden cardiac death (SCD). In younger individuals coronary artery disease is less prevalent and cardiac genetic disorders are more common.
Behr, ER, Miles, CJ
core   +1 more source

Investigação de variantes gênicas de canais iônicos em pacientes com síndrome do QT longo

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: A síndrome do QT longo (SQTL) é uma síndrome arrítmica herdada com aumento do intervalo QT e risco de morte súbita. Mutações nos genes KCNQ1, KCNH2 e SCN5A respondem por 90% dos casos com genótipo determinado, e a genotipagem é informativa ...
Ernesto Curty, Fernando Eugênio dos Santos Cruz, Fabiane Santos Lima, Jorge Luiz Albuquerque Coutinho, Rosane Silva, Turán Peter Ürményi, Antônio Carlos Campos Carvalho, Edson Rondinelli   +7 more
doaj