Results 101 to 110 of about 313 (129)

Regulation of HERG (KCNH2) potassium channel surface expression by diacylglycerol

Cellular and Molecular Life Sciences, 2009
The HERG (KCNH2) channel is a voltage-sensitive potassium channel mainly expressed in cardiac tissue, but has also been identified in other tissues like neuronal and smooth muscle tissue, and in various tumours and tumour cell lines. The function of HERG has been extensively studied, but it is still not clear what mechanisms regulate the surface ...
Cia, Ramström, Hugh, Chapman, Tero, Viitanen, Emad, Afrasiabi, Heli, Fox, Johanna, Kivelä, Sanna, Soini, Laura, Korhonen, Dan, Lindholm, Michael, Pasternack, Kid, Törnquist   +10 more
openaire   +2 more sources

A novel mutation in the KCNH2 gene associated with short QT syndrome

Journal of Molecular and Cellular Cardiology, 2011
A gain of function mutation N588K in the KCNH2 gene that encodes HERG channels has been shown to underlie the SQT1 form of short QT syndrome (SQTS). We describe a different mutation in the KCNH2 gene in a Chinese family with clinical evidence of SQTS. A Chinese family with a markedly short QT interval (QTc=316 ± 9 ms, n=4) and a strong family history ...
Yaxun, Sun, Xiao-Qing, Quan, Samantha, Fromme, Robert H, Cox, Ping, Zhang, Li, Zhang, Donglin, Guo, Jihong, Guo, Chinmay, Patel, Peter R, Kowey, Gan-Xin, Yan   +10 more
openaire   +2 more sources

Genetic Polymorphism of KCNH2 Confers Predisposition of Acquired Atrial Fibrillation in Chinese

Journal of Cardiovascular Electrophysiology, 2009
Introduction: Nonfamiliar atrial fibrillation (AF) is usually associated with acquired structural heart disease, including valvular heart disease, coronary artery disease, and hypertension. Suggestive evidence indicates that these forms of acquired AF are more likely to occur in individuals with a genetic predisposition.
Qun-Shan, Wang, Xiao-Feng, Wang, Xing-Dong, Chen, Jie-Fei, Yu, Jun, Wang, Jian, Sun, Shang-Biao, Lu, Mu-Yao, Shen, Ming, Lu, Yi-Gang, Li, Li, Jin   +10 more
openaire   +2 more sources

Decoding KCNH2 variants of unknown significance

Heart Rhythm, 2020
Carlos G, Vanoye, Alfred L, George
openaire   +2 more sources

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels

American Journal of Physiology-Heart and Circulatory Physiology, 2004
Long QT syndrome (LQTS) is a cardiac repolarization disorder that can lead to arrhythmias and sudden death. Chromosome 7-linked inherited LQTS (LQT2) is caused by mutations in human ether-a-go-go-related gene ( HERG; KCNH2), whereas drug-induced LQTS is caused primarily by HERG channel block.
Blake D, Anson, Michael J, Ackerman, David J, Tester, Melissa L, Will, Brian P, Delisle, Corey L, Anderson, Craig T, January   +6 more
openaire   +2 more sources

Dissecting the associations of KCNH2 genetic polymorphisms with various types of cardiac arrhythmias

Gene
Cardiac arrhythmia, a common cardiovascular disease, is closely related to genetic polymorphisms. However, the associations between polymorphisms in KCNH2 and various arrhythmias remain inadequately explored.Guided by the assumption that KCNH2 genetic polymorphisms significantly contribute to the development of arrhythmias, we thoroughly explored the ...
Sen Li, Zhang Zhang, Yining Ding, Tingting Yu, Zongshi Qin, Shuzhen Guo   +5 more
openaire   +2 more sources

Kcnh2 mediates FAK/AKT‐FOXO3A pathway to attenuate sepsis‐induced cardiac dysfunction

Cell Proliferation, 2021
Zhi-Gang Li, Huan Liu, Luying Peng
exaly  

KCNH2 p.Gly262AlafsTer98: A New Threatening Variant Associated with Long QT Syndrome in a Spanish Cohort

Life, 2022
Isaac Pascual, Perez-Perez A, Cesar Moris   +2 more
exaly  

Gene symbol: KCNH2.

Human genetics, 2007
L, Crotti, R, Insolia, M, Pedrazzini, C, Andreoli, E, Gabanti, C, Moncalvo, G, Crimi, G M, De Ferrari, P J, Schwartz   +8 more
openaire   +3 more sources

KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression

Proceedings of the National Academy of Sciences of the United States of America, 2023
FRANCISCO Sánchez-Conde, David Jones, Abhilasha Jain   +2 more
exaly