Results 101 to 110 of about 6,642 (199)

Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development

, 2004
To understand molecular mechanisms that regulate formation and maintenance of cardiac IKr (rapidly activating component of the delayed rectifier K+ current), we have investigated the spatiotemporal expression pattern of two rat potassium voltage-gated ...
Chun, J., Zehelein, J., Katus, H., Koenen, M.   +3 more
core  

Expression of KCNH2 (hERG1) and KCNE2 correlates with expression of key myometrial genes in term pregnant human myometrium

, 2017
Background: Loss of activity of Kv11.1 potassium channels (encoded by KCNH2) facilitates labor, and is associated with expression of an inhibitory subunit encoded by KCNE2.
Roger Smith (21134273), Marina Ilicic (9380765), Jonathan Paul (21128576), Tamas Zakar (21132203)   +3 more
core  

KCNH2-K897T Is a Genetic Modifier of Latent Congenital Long-QT Syndrome.

, 2005
BACKGROUND: Clinical heterogeneity among patients with long-QT syndrome (LQTS) sharing the same disease-causing mutation is usually attributed to variable penetrance.
Ferrandi C, SCHWARTZ, PETER, Vicentini A, Roden DM, Lundquist AL, Yang P, INSOLIA, ROBERTO, DE FERRARI, GAETANO, CROTTI, LIA, George AL Jr, Pedrazzini M   +10 more
core   +2 more sources

Molecular cloning and functional expression of the equine K+ channel KV11.1 (ether à go-go-related/KCNH2 gene) and the regulatory subunit KCNE2 from equine myocardium Figure 9

, 2015
Molecular cloning and functional expression of the equine K+ channel KV11.1 (ether à go-go-related/KCNH2 gene) and the regulatory subunit KCNE2 from equine ...
Kirstine Calloe (790540)
core   +1 more source

Generation of KCNH2 heterozygous knockout induced pluripotent stem cell (iPSC) line (Long and Short QT Syndrome)

Stem Cell Research
KCNH2 (Potassium Voltage-Gated Channel Subfamily H Member) encodes a voltage-activated potassium channel role as rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of the ventricular action ...
Baiqiang Wang, Qian Ren, Xiaomeng Cui, Wei shan, Xiangge Guo, Xumeng Wang, Jiaxuan Wang, Yanting Li, Guipeng An   +8 more
doaj   +1 more source

Generation of human induced pluripotent stem cell lines from a fetus with congenital long QT syndrome and her healthy parents

Stem Cell Research
Long QT syndrome (LQTS) is a channelopathy that predisposes affected individuals to ventricular arrhythmias and cardiac arrest. Here, a human induced pluripotent stem cell (hiPSC) line was generated from amniotic fluid cells (AFCs) of a 32-week fetus ...
Manesha Putra, Bettina F. Cuneo, Congwu Chi, Zhen Zhang, Linnea Prudell, Kunhua Song   +5 more
doaj   +1 more source

Establishment of a human-induced pluripotent stem cell line from a long QT syndrome type 2 patient harboring a KCNH2 mutation

Stem Cell Research
Long QT syndrome type 2 (LQT2) is a heart disorder resulting from a loss-of-function mutation in the KCNH2 gene that causes loss of Kv11.1 channel function, potentially resulting in syncope, arrhythmias, and sudden death.
Dasom Mun, Ji-Young Kang, Malgeum Park, Gyeongseo Yoo, Hyoeun Kim, Nuri Yun, You Mi Hwang, Boyoung Joung   +7 more
doaj   +1 more source

Potassium channel Kv11.1 (KCNH2) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Comparison of the prevalence of four coding polymorphisms of KCNH2 in healthy Kurds and Malays

, 2018
KCNH2 polymorphisms appear to be associated with arrhythmia susceptibility, drug-associated acquired long-QT syndrome and variability in drug responses. To date, little is known about the prevalence of KCNH2 polymorphisms among Kurds and Malays.
Zawiyah, Derani, Zalina, Zahari, Muslih, Abdulkarim Ibrahim, Nurfadhlina, Musa   +3 more
core   +1 more source

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients

, 2004
Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients. Paulussen AD, Gilissen RA, Armstrong M, Doevendans PA, Verhasselt P, Smeets HJ, Schulze-Bahr E, Haverkamp W, Breithardt G, Cohen N, Aerssens J ...
Smeets, H.J.M., Schulze-Bahr, E., Breithardt, G., Cohen, N., Gilissen, R., Armstrong, M., Paulussen, A.D., Verhasselt, P., Doevendans, P.A.F.M., Haverkamp, W., Aerssens, J.M.M.R.   +10 more
core   +1 more source