Results 1 to 10 of about 974 (83)

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

Physiological Reports, 2023
In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle.
Vincenzo Barrese, Zena Wehbe, Alice Linden, Sarah McDowell, Elizabeth Forrester, Oleksander Povstyan, Karen D. McCloskey, Iain A. Greenwood   +7 more
doaj   +2 more sources

The ERG1 K+ Channel and Its Role in Neuronal Health and Disease

Frontiers in Molecular Neuroscience, 2022
The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain.
Francisco G. Sanchez-Conde, Eric N. Jimenez-Vazquez, David S. Auerbach, David K. Jones, David K. Jones   +4 more
doaj   +3 more sources

Expression of the ether-a-gò-gò-related gene 1 channel during B and T lymphocyte development: role in BCR and TCR signaling [PDF]

Frontiers in Immunology, 2023
The functional relevance of K+ and Ca2+ ion channels in the “Store Operated Calcium Entry” (SOCE) during B and T lymphocyte activation is well proven. However, their role in the process of T- and B- cell development and selection is still poorly defined.
Cesare Sala, Martina Staderini, Tiziano Lottini, Claudia Duranti, Gabriele Angelini, Gabriela Constantin, Annarosa Arcangeli   +6 more
doaj   +2 more sources

The ERG1A K⁺ Channel Is More Abundant in Rectus abdominis Muscle from Cancer Patients Than that from Healthy Humans

Diagnostics, 2021
Background: The potassium channel encoded by the ether-a-gogo-related gene 1A (erg1a) has been detected in the atrophying skeletal muscle of mice experiencing either muscle disuse or cancer cachexia and further evidenced to contribute to muscle ...
Sandra Zampieri, Marco Sandri, Joseph L. Cheatwood, Rajesh P. Balaraman, Luke B. Anderson, Brittan A. Cobb, Chase D. Latour, Gregory H. Hockerman, Helmut Kern, Roberta Sartori, Barbara Ravara, Stefano Merigliano, Gianfranco Da Dalt, Judith K. Davie, Punit Kohli, Amber L. Pond   +15 more
doaj   +1 more source

Two new cases of interstitial 7q35q36.1 deletion including CNTNAP2 and KMT2C

Molecular Genetics &Genomic Medicine, Volume 9, Issue 11, November 2021., 2021
Interstitial deletions of the long arm of chromosome 7 including CNTNAP2 and excluding the SHH region are not common. We report the clinical and molecular characterization associated with pure 7q35 and 7q35q36.1 deletion in two unrelated patients. Combined haploinsufficiency of GALNTL5, CUL1, SSPO, AOC1, RHEB and KMT2C with monoallelic disruption of ...
Lucie Tosca, Loïc Drévillon, Aurélie Mouka, Laure Lecerf, Audrey Briand, Valérie Ortonne, Virginie Benoit, Sophie Brisset, Lionel Van Maldergem, Quitterie Laudouar, Solveig Heide, Michel Goossens, Irina Giurgea, Gérard Tachdjian, Corinne Métay   +14 more
wiley   +1 more source

Kv11 (ether‐à‐go‐go‐related gene) voltage‐dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials

The Journal of Physiology, Volume 599, Issue 2, Page 547-569, 15 January 2021., 2021
Key points Some ion channels are known to behave as inductors and make up the parallel resonant circuit in the plasma membrane of neurons, which enables neurons to respond to current inputs with a specific frequency (so‐called ‘resonant properties’).
Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto   +8 more
wiley   +1 more source

Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Background. Paeoniae Radix Alba (PRA), the root of the plant Paeonia lactiflora Pall., has been suggested to play an important role for the treatment of asthma. A biochemical understanding of the clinical effects of Paeoniae Radix Alba is needed. Here, we explore the phytochemicals and therapeutic mechanisms via a systematic and comprehensive network ...
Jingwei Wang, Ling Peng, Lu Jin, Huiying Fu, Qiyang Shou, Kai Wang   +5 more
wiley   +1 more source

The ERG1 Potassium Channel is More Abundant in Skeletal Muscle from Cachectic than Healthy Humans [PDF]

, 2020
Abstract Background: The ERG1a potassium channel has been detected in the atrophying skeletal muscle of mice experiencing either muscle disuse or cancer cachexia and further evidenced to contribute to muscle deterioration by enhancing ubiquitin proteolysis; however, to our knowledge, ERG1 has not been reported in human skeletal muscle.
Sandra Zampieri, Marco Sandri, Joseph L. Cheatwood, Rajesh P. Balaraman, Luke B. Anderson, Brittan A. Cobb, Chase D. Latour, Gregory H. Hockerman, Helmut Kern, Roberta Sartori, Barbara Ravara, Stefano Merigliano, Gianfranco Da Dalt, Judith K. Davie, Punit Kohli, Ugo Carraro, Amber L Pond   +16 more
openaire   +1 more source

The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating

Frontiers in Pharmacology, 2020
EAG (ether-à-go-go or KCNH) are a subfamily of the voltage-gated potassium (Kv) channels. Like for all potassium channels, opening of EAG channels drives the membrane potential toward its equilibrium value for potassium, thus setting the resting ...
Francisco Barros, Pilar de la Peña, Pedro Domínguez, Luisa Maria Sierra, Luis A. Pardo   +4 more
doaj   +1 more source

Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates I _Kr in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia [PDF]

Molecular and Cellular Biology, 2003
The ERG1 gene encodes a family of potassium channels. Mutations in human ERG1 lead to defects in cardiac repolarization, referred to as the long QT syndrome. Through homologous recombination in mouse embryonic stem cells the ERG1 B potassium channel transcript was eliminated while the ERG1 A transcript was maintained.
James P, Lees-Miller, Jiqing, Guo, Julie R, Somers, Dan E, Roach, Robert S, Sheldon, Derrick E, Rancourt, Henry J, Duff   +6 more
openaire   +2 more sources