Results 11 to 20 of about 974 (83)

Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System

Oxidative Medicine and Cellular Longevity, Volume 2017, Issue 1, 2017., 2017
Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage‐gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage‐gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox ...
Bo Han, Tursonjan Tokay, Guangming Zhang, Peng Sun, Shangwei Hou, Rodrigo Franco   +5 more
wiley   +1 more source

Update on the Pathogenic Implications and Clinical Potential of microRNAs in Cardiac Disease

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
miRNAs, a unique class of endogenous noncoding RNAs, are highly conserved across species, repress gene translation upon binding to mRNA, and thereby influence many biological processes. As such, they have been recently recognized as regulators of virtually all aspects of cardiac biology, from the development and cell lineage specification of different ...
Mario Notari, Julián Pulecio, Ángel Raya, Chi-Hsiao Yeh   +3 more
wiley   +1 more source

Ion Channels in Glioblastoma

International Scholarly Research Notices, Volume 2011, Issue 1, 2011., 2011
Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated
Remco J. Molenaar, A. Gambardella, J. A. Rey, R. Yamanaka   +3 more
wiley   +1 more source

Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)

Pulmonary Circulation, Volume 15, Issue 1, January 2025.
ABSTRACT Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and ...
Lindsay M. Forbes, Natalie Bauer, Aritra Bhadra, Harm J. Bogaard, Gaurav Choudhary, Kara N. Goss, Stefan Gräf, Gustavo A. Heresi, Rachel K. Hopper, Arun Jose, Yunhye Kim, Timothy Klouda, Tim Lahm, Allan Lawrie, Peter J. Leary, Jane A. Leopold, Suellen D. Oliveira, Sasha Z. Prisco, Ruslan Rafikov, Christopher J. Rhodes, Duncan J. Stewart, Rebecca R. Vanderpool, Ke Yuan, Alexsandra Zimmer, Anna R. Hemnes, Vinicio A. de Jesus Perez, Martin R. Wilkins   +26 more
wiley   +1 more source

Erg currents support electrical bursting in murine anterior pituitary corticotrophs. [PDF]

J Physiol
Nair SV, Romanò N, Duncan PJ, Tissier PL, Bertram R, Shipston MJ.   +5 more
europepmc   +1 more source

Voltage-gated potassium channels as important modulators of glucose-stimulated insulin secretion in pancreatic β-cells: insights from rodent and human studies. [PDF]

Front Endocrinol (Lausanne)
Xing JJ, Chen C.
europepmc   +1 more source

Establishment and Characterization of a Stable hERG Cell Line for High-Throughput Drug Cardiac Safety Screening. [PDF]

Int J Mol Sci
Lu H, Guo Q, Qiu Q, Hu J.
europepmc   +1 more source

Long QT interval syndrome type 2 caused by a new missense mutation of KCNH2 gene: A case report. [PDF]

Medicine (Baltimore)
Ma Y, Wang L, Wu S, Peng C.
europepmc   +1 more source

The PAS domain directly regulates hERG channel gating in patch-clamp fluorometry recordings. [PDF]

Biophys J
Trudeau MC.
europepmc   +1 more source

The exquisite link between potassium homeostasis regulation and cardiovascular health: exploration and analysis. [PDF]

Front Physiol
Wang C, Huang X, Zhang Z, Lin D, Huang S.   +4 more
europepmc   +1 more source