Results 1 to 10 of about 20,804 (181)

Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin. [PDF]

EMBO J, 2000
Intracellular Ca(2+) inhibits voltage-gated potassium channels of the ether à go-go (EAG) family. To identify the underlying molecular mechanism, we expressed the human version hEAG1 in Xenopus oocytes. The channels lost Ca(2+) sensitivity when measured in cell-free membrane patches.
Schönherr R, Löber K, Heinemann SH.
europepmc   +5 more sources

Amiodarone irrecoverably impairs the function of human ether-a-go-go-related gene potassium channels. [PDF]

Mol Pharmacol
The class III antiarrhythmic drug amiodarone (AMIO) inhibits the rapidly activating delayed rectifier K+ current that is conducted by the human ether-a-go-go-related gene (hERG) encoded channel. Like other class III antiarrhythmic drugs, AMIO can cause long QT syndrome. In the present study, we investigated the effects of AMIO and its major metabolite,
Gelman I, Li W, Guo J, Bogart-Cherry R, Tomei N, Sharma N, Pan A, Yang T, Baranchuk A, El-Diasty M, Zhang S.   +10 more
europepmc   +4 more sources

Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules [PDF]

Acta Pharmacologica Sinica, 2011
Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). However, the channels can be inhibited by structurally diverse small molecules, resulting in an acquired form of ...
Gao Zhao-Bing
exaly   +4 more sources

Ether à go-go Potassium Channels as Human Cervical Cancer Markers [PDF]

Cancer Research, 2004
Abstract Ether à go-go (EAG) potassium channels display oncogenic properties. In normal tissues, EAG mRNA is almost exclusively expressed in brain, but it is expressed in several somatic cancer cell lines, including HeLa, from cervix. Antisense experiments against eag reduce cell proliferation in some cancer cell lines, and inhibition ...
Barajas Farias, L., Bermúdez Ocaña, D., Díaz, L., Larrea, F., Avila-Chávez, E., Cadena, A., Hinojosa, L., Lara, G., Villanueva, L., Vargas, C., Hernández-Gallegos, E., Camacho-Arroyo, I., Dueñas-González, A., Pérez-Cárdenas, E., Pardo, L., Morales, A., Taja-Chayeb, L., Escamilla, J., Sánchez-Peña, C., Camacho, J.   +19 more
openaire   +4 more sources

Extracellular Mg2+ Modulates Slow Gating Transitions and the Opening of Drosophila Ether-à-Go-Go Potassium Channels

Journal of General Physiology, 2000
We have characterized the effects of prepulse hyperpolarization and extracellular Mg2+ on the ionic and gating currents of the Drosophila ether-à-go-go K+ channel (eag).
Diane M Papazian, FRANCISCO Bezanilla, Chih-Yung Tang   +2 more
exaly   +2 more sources

Ether-a-go-go Related Gene Potassium Channels: What's All the Buzz About? [PDF]

Schizophrenia Bulletin, 2006
Antipsychotic drugs are thought to exert their therapeutic action by antagonizing dopamine receptors but are also known to produce side effects in the heart by inhibiting cardiac ether-a-go-go-related gene (ERG) K(+) channels. Recently, it has been discovered that the same channels are present in the brain, including midbrain dopamine neurons.
Paul D, Shepard, Carmen C, Canavier, Edwin S, Levitan   +2 more
openaire   +3 more sources

The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether‐à‐go‐go related gene 1 channels

The Journal of Physiology, 2022
AbstractPotassium channels are often dysregulated in tumours of the gastrointestinal (GI) tract. Among them, the voltage‐dependent channel KV11.1, also known as human ether‐à‐go‐go related gene 1 (hERG1), is frequently expressed in tumours and precancerous lesions of the GI tract.
Arcangeli, Annarosa, Duranti, Claudia, Iorio, Jessica, Lastraioli, Elena   +3 more
openaire   +3 more sources

Mg2+ Modulates Voltage-Dependent Activation in Ether-à-Go-Go Potassium Channels by Binding between Transmembrane Segments S2 and S3

Journal of General Physiology, 2000
Extracellular Mg2+ directly modulates voltage-dependent activation in ether-à-go-go (eag) potassium channels, slowing the kinetics of ionic and gating currents (Tang, C.-Y., F. Bezanilla, and D.M. Papazian. 2000. J. Gen. Physiol. 115:319-337).
Diane M Papazian, Chih-Yung Tang, Papazian Diane M   +2 more
exaly   +2 more sources

Second-generation antipsychotics – Cardiac ion channel modulation and QT interval disturbances: A review [PDF]

Biomolecules & Biomedicine
Second-generation antipsychotics (SGAs) are frequently prescribed in psychiatry due to their efficacy and improved tolerability compared to first-generation agents.
Orhan Erkan, Ayse Suna Dai, Nihal Ozturk, Semir Ozdemir   +3 more
doaj   +2 more sources

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

Journal of Biological Chemistry, 2011
Congenital long QT syndrome 2 (LQT2) is caused by loss-of-function mutations in the human ether-á-go-go-related gene (hERG) voltage-gated potassium (K+) channel.
Matthew Trudeau
exaly   +2 more sources