Results 41 to 50 of about 20,804 (181)
β-Arrestin-Mediated Regulation of the Human Ether-a-go-go-Related Gene Potassium Channel [PDF]
Molecular Pharmacology, 2017 The rapidly activating delayed rectifier K+ channel (IKr) is encoded by the human ether-a-go-go-related gene (hERG), which is important for the repolarization of the cardiac action potential. Mutations in hERG or drugs can impair the function or decrease the expression level of hERG channels, leading to long QT syndrome.
Matthew G, Sangoi +7 more
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Rac and Rho Mediate Opposing Hormonal Regulation of the Ether-A-Go-Go-Related Potassium Channel [PDF]
Current Biology, 2002 Previous studies of ion channel regulation by G proteins have focused on the larger, heterotrimeric GTPases, which are activated by heptahelical membrane receptors. In contrast, studies of the Rho family of smaller, monomeric, Ras-related GTPases, which are activated by cytoplasmic guanine nucleotide exchange factors, have focused on their role in ...
Storey, N.M. +2 more
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Eag1 Channels as Potential Cancer Biomarkers
Sensors, 2012 Cancer is a leading cause of death worldwide. New early tumor markers are needed to treat the disease at curable stages. In addition, new therapeutic targets are required to treat patients not responding to available treatments.
Javier Camacho +2 more
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Emerging roles for ether‐á‐go‐go‐related gene potassium channels in the brain
The Journal of Physiology, 2008 Voltage-activated ether-a-go-go-related gene (ERG1a, Kv11) potassium channels play a prominent role in regulating cardiac excitability and in heart disease. Recently, ERG channels were found to be widely distributed in brain (Papa et al. 2003; Guasti et al. 2005), although little is currently known regarding their functional role in the nervous system.
Paul D, Shepard, Matthew C, Trudeau
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The Journal of General Physiology, 1998 Abnormalities in repolarization of the cardiac ventricular action potential can lead to life-threatening arrhythmias associated with long QT syndrome.
Jinling Wang +3 more
semanticscholar +1 more source
The molecular determinants of R-roscovitine block of hERG channels.
PLoS ONE, 2019 Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (IKr) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K+channels and
Bryan Cernuda +7 more
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Natural antisense transcripts regulate the neuronal stress response and excitability
eLife, 2014 Neurons regulate ionic fluxes across their plasma membrane to maintain their excitable properties under varying environmental conditions. However, the mechanisms that regulate ion channels abundance remain poorly understood.
Xingguo Zheng +3 more
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Journal of Pharmacological Sciences, 2004 While aldosterone receptor blockers improve survival of patients with congestive heart failure, spironolactone and its derivatives were recently shown to block ether-a-go-go-related gene (HERG) channels and native IKs and IKr currents in guinea pig ...
Atsushi Sugiyama +7 more
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The Study on the hERG Blocker Prediction Using Chemical Fingerprint Analysis
Molecules, 2020 Human ether-a-go-go-related gene (hERG) potassium channel blockage by small molecules may cause severe cardiac side effects. Thus, it is crucial to screen compounds for activity on the hERG channels early in the drug discovery process.
Kwang-Eun Choi +2 more
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Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
Pharmaceuticals, 2023 hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell +4 more
doaj +1 more source