Pharmacogenetics of Potassium Channel Blockers [PDF]
Cardiac Electrophysiology Clinics, 2016 The QT interval on surface electrocardiograms provides a model of a multicomponent integrated readout of many biological systems, including ion channels, modulatory subunits, signaling systems that modulate their activity, and mechanisms that regulate the expression of their responsible genes.
Dan Roden
exaly +5 more sources
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
Respiratory Research, 2006 Background KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to ...
Balan Prabhu +2 more
doaj +7 more sources
Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients. [PDF]
Card Electrophysiol Clin, 2016 The most common arrhythmia requiring drug treatment is atrial fibrillation (AF), which affects 2 to 5 million Americans and continues to be a major cause of morbidity and increased mortality. Despite recent advances in catheter-based and surgical therapies, antiarrhythmic drugs continue to be the mainstay of therapy for most patients with symptomatic ...
McCauley M, Vallabhajosyula S, Darbar D.
europepmc +4 more sources
Photochromic potassium channel blockers: design and electrophysiological characterization. [PDF]
Methods Mol Biol, 2013 Voltage-gated potassium (K v) channels are membrane proteins that open a selective pore upon membrane depolarization, allowing K(+) ions to flow down their electrochemical gradient. In neurons, K v channels play a key role in repolarizing the membrane potential during the falling phase of the action potential, often resulting in an after ...
Mourot A, Fehrentz T, Kramer RH.
europepmc +4 more sources
Identification of cellular ion channels that facilitate Hazara nairovirus infection enables selection of clinically approved compounds with anti-nairoviral properties [PDF]
Scientific ReportsThe Nairoviridae family of segmented negative-sense RNA viruses includes the serious human pathogen Crimean-Congo haemorrhagic fever virus (CCHFV), associated with a case/fatality rate of up to 40% for which no approved vaccines or treatments exist ...
Frank W. Charlton +8 more
doaj +2 more sources
Potassium channel blockers restore axonal conduction in CNS trauma and disease
Neural Regeneration Research, 2016 Jessica C Page, Riyi Shi
doaj +2 more sources
Palmitic acid reduces cytosolic potassium and induces IL-1β production in lipopolysaccharide-primed human macrophages [PDF]
Journal of Nutritional ScienceSaturated fatty acids, particularly palmitic acid (PA), promote inflammation and contribute to chronic diseases such as type 2 diabetes and cardiovascular disease.
Jyue-Wei Chuang, Shao-Chun Lu
doaj +2 more sources
Сardioprotective agents with biaromatic structure. Part 5. Potassium Kv1.5-channels blockers
Фармакокинетика и Фармакодинамика, 2023 The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, IKur, that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ...
G. V. Mokrov
doaj +1 more source
Role of the potassium channels in vasorelaxant effect of asafoetida essential oil [PDF]
Avicenna Journal of Phytomedicine, 2020 Objective: In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of Ferula asafoetida L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent.
Hassan Esmaeili +3 more
doaj +1 more source
Potassium channels: Novel targets for tumor diagnosis and chemoresistance
Frontiers in Oncology, 2023 In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells.
Meizeng Li +4 more
doaj +1 more source