Results 21 to 30 of about 44,135 (257)
Influence of antihypertensive therapy, sodium intake and the concentration of potassium in plasma on concentration of aldosterone and plasma renin activity [PDF]
Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2013 Introduction: Primary aldosteronism (PA) is a group of disorders which are characterized by inadequate and non-suppressible production of aldosterone. The prevalence of PA is increasing in hypertensive population.
Lalić Tijana
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Photochromic Blockers of Voltage‐Gated Potassium Channels [PDF]
Angewandte Chemie International Edition, 2009 Photochromic ligands (PCLs) can be optically switchedbetween isomers that show different biological activities. Assuch, they offer an opportunity to convert ligand-actuatedpathways into light-actuated pathways, thus making it possi-ble to control a wide range of biological processes with light.PCLs have been explored for various classes of ...
Matthew R, Banghart +5 more
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Antiarrhythmic drug usage and prostate cancer: a population-based cohort study
Asian Journal of Andrology, 2018 Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent.
Li-Ting Kao +3 more
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Molecules, 2021 TASK channels belong to the two-pore-domain potassium (K2P) channels subfamily. These channels modulate cellular excitability, input resistance, and response to synaptic stimulation. TASK-channel inhibition led to membrane depolarization.
David Ramírez +10 more
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Bioengineered System for High Throughput Screening of Kv1 Ion Channel Blockers
Bioengineering, 2021 Screening drug candidates for their affinity and selectivity for a certain binding site is a crucial step in developing targeted therapy. Here, we created a screening assay for receptor binding that can be easily scaled up and automated for the high ...
George V. Sharonov +4 more
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Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840 [PDF]
Expert Opinion on Therapeutic Patents, 2010 Heike Wulff
exaly +2 more sources
Scientific Reports, 2021 The activation of mitochondrial large conductance calcium-activated potassium (mitoBKCa) channels increases cell survival during ischemia/reperfusion injury of cardiac cells.
Shur Gałecka +4 more
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Conformational exchange in the potassium channel blocker ShK [PDF]
Scientific Reports, 2019 AbstractShK is a 35-residue disulfide-linked polypeptide produced by the sea anemone Stichodactyla helianthus, which blocks the potassium channels Kv1.1 and Kv1.3 with pM affinity. An analogue of ShK has been developed that blocks Kv1.3 > 100 times more potently than Kv1.1, and has completed Phase 1b clinical trials for the treatment of autoimmune ...
Iwakawa, N. +7 more
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Membranes, 2023 The voltage-gated potassium channel Kv1.1, which is abundant in the CNS and peripheral nervous system, controls neuronal excitability and neuromuscular transmission and mediates a number of physiological functions in non-excitable cells.
Nikita A. Orlov +7 more
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Anaesthetic phencyclidine, blocker of the ATP‐sensitive potassium channels [PDF]
FEBS Letters, 1994 The double sucrose gap and patch‐clamp studies revealed that phencyclidine blocked the ATP‐sensitive K+ channel in isolated cardiac cells (half‐maximal inhibition at ≈20 μM; Hill coefficient ≈1). 10μM phencyclidine increased the inward Ca2+ current and blocked the outward K+ current in the frog auricle trabeculae.
Kokoz, Yuri M. +4 more
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