Results 11 to 20 of about 44,135 (257)

Combining mKate2-Kv1.3 Channel and Atto488-Hongotoxin for the Studies of Peptide Pore Blockers on Living Eukaryotic Cells

Toxins, 2022
The voltage-gated potassium Kv1.3 channel is an essential component of vital cellular processes which is also involved in the pathogenesis of some autoimmune, neuroinflammatory and oncological diseases.
Nikita A. Orlov, Anastasia A. Ignatova, Elena V. Kryukova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Oksana V. Nekrasova, Alexey V. Feofanov   +6 more
doaj   +1 more source

Computational prediction of hERG blockers using homology modelling, molecular docking and QuaSAR studies

Results in Chemistry, 2021
A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
doaj   +1 more source

Identification of a novel potassium channel (GiK) as a potential drug target in Giardia lamblia: Computational descriptions of binding sites [PDF]

PeerJ, 2019
Background The protozoan Giardia lamblia is the causal agent of giardiasis, one of the main diarrheal infections worldwide. Drug resistance to common antigiardial agents and incidence of treatment failures have increased in recent years.
Lissethe Palomo-Ligas, Filiberto Gutiérrez-Gutiérrez, Verónica Yadira Ochoa-Maganda, Rafael Cortés-Zárate, Claudia Lisette Charles-Niño, Araceli Castillo-Romero   +5 more
doaj   +2 more sources

The effect of potential-dependent potassium uptake on membrane potential in rat brain mitochondria [PDF]

The Ukrainian Biochemical Journal, 2013
The effect of potential-dependent potassium uptake on the transmembrane potential difference (ΔΨm) in rat brain mitochondria has been studied­. It was shown that in potassium concentration range of 0-120 mM the potential-dependent K+-uptake into matrix ...
O. V. Akopova, V. I. Nosar, L. I. Kolchinskaya, I. N. Mankovska, M. K. Malysheva, V. F. Sagach   +5 more
doaj   +1 more source

Effects of potassium channel modulators on the responses of mammalian slowly adapting mechanoreceptors

IBRO Neuroscience Reports, 2022
Introduction: slowly adapting mechanoreceptors in the skin provide vital tactile information to animals. The ionic channels that underlie their functioning is the subject of intense research.
Peter M.B. Cahusac, Solomon S. Senok
doaj   +1 more source

Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators

Фармакокинетика и Фармакодинамика, 2023
The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents.
G. V. Mokrov
doaj   +1 more source

Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block. [PDF]

PLoS ONE, 2009
BACKGROUND:Understanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function and for the discovery and development of ion channel directed drugs ...
Franck C Chatelain, Sabrina Gazzarrini, Yuichiro Fujiwara, Cristina Arrigoni, Courtney Domigan, Giuseppina Ferrara, Carlos Pantoja, Gerhard Thiel, Anna Moroni, Daniel L Minor   +9 more
doaj   +1 more source

Plectasin, First Animal Toxin-Like Fungal Defensin Blocking Potassium Channels through Recognizing Channel Pore Region

Toxins, 2015
The potassium channels were recently found to be inhibited by animal toxin-like human β-defensin 2 (hBD2), the first defensin blocker of potassium channels. Whether there are other defensin blockers from different organisms remains an open question. Here,
Fang Xiang, Zili Xie, Jing Feng, Weishan Yang, Zhijian Cao, Wenxin Li, Zongyun Chen, Yingliang Wu   +7 more
doaj   +1 more source

Protective Effect of Peptide Calcium Channel Blocker Omega-Hexatoxin-Hv1a on Epithelial Cell during Ischemia–Reperfusion Injury

Pharmaceuticals, 2023
Ischemia–reperfusion injury (IRI) is a common phenomenon that develops both from natural causes and during major operations. Many intracellular processes mediated by calcium ions are involved in the development of IRI. Currently, chemical calcium channel
Elena Iurova, Eugenia Rastorgueva, Evgenii Beloborodov, Evgeniya Pogodina, Aleksandr Fomin, Dmitrii Sugak, Denis Viktorov, Ivan Tumozov, Yury Saenko   +8 more
doaj   +1 more source

Pharmacological Treatment for Atrial Fibrillation

Journal of Arrhythmia, 2005
Pharmacological treatment for atrial fibrillation has a variety of purposes, such as pharmacological defibrillation, maintenance of sinus rhythm, heart rate control to prevent congestive heart failure and prevention of both cerebral infarction and atrial
Kaoru Sugi, MD PhD, Mahito Noro, MD PhD, Takao Sakata, MD PhD, Naoki Tezuka, MD, Takeshi Nakae, MD, Kenta Kumagai, MD, Tsuyoshi Sakai, MD PhD, Ayaka Numata, MD PhD, Hidetoshi Itakura, MD, Akiyoshi Moriyama, MD, Shingo Kujime, MD   +10 more
doaj   +1 more source