Results 21 to 30 of about 20,804 (181)
Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility
Physiological Reports, 2023 In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle.
Vincenzo Barrese +7 more
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Micromachines, 2021 The reconstitution of ion-channel proteins in artificially formed bilayer lipid membranes (BLMs) forms a well-defined system for the functional analysis of ion channels and screening of the effects of drugs that act on these proteins.
Ryusuke Miyata +9 more
doaj +1 more source
Assay and Drug Development Technologies, 2010 Haibo Yu, Joel Bader, Owen B Mcmanus
exaly +2 more sources
Eag and HERG potassium channels as novel therapeutic targets in cancer
World Journal of Surgical Oncology, 2010 Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential ...
Bali Anish +4 more
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Blockade of the Human Ether A-Go-Go–Related Gene (hERG) Potassium Channel by Fentanyl [PDF]
Molecular Pharmacology, 2019 The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr). Drug-mediated or medical condition-mediated disruption of hERG function is the primary cause of acquired long-QT syndrome, which predisposes affected individuals to ventricular arrhythmias and sudden death ...
Jared N, Tschirhart +3 more
openaire +2 more sources
Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
Frontiers in Chemistry, 2019 Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1–L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE).
Xiaomeng Zhang +4 more
doaj +1 more source
Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. [PDF]
PLoS ONE, 2017 The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.
Dahai Yu +8 more
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Cloning of a human ether‐a‐go‐go potassium channel expressed in myoblasts at the onset of fusion [PDF]
FEBS Letters, 1998 An early sign of human myoblast commitment to fusion is the expression of a non‐inactivating delayed rectifier K+ current, IK(NI), and an associated membrane potential hyperpolarization. We have isolated the full‐length coding region of a human ether‐a‐go‐go K+ channel (h‐eag) from myoblasts undergoing differentiation.
Occhiodoro, T. +6 more
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Analysis of ether-à-go-go potassium channel (Eag1) splice variants in melanoma cells [PDF]
, 2022 Der menschliche Ether-à-go-go Kaliumkanal (hEag1) nachgewiesen werden in adulten Gehirn und in beiden Tumorzelllinien und primären Tumoren. Das physiologische Funktion dieses Kanals im Gehirn bleibt zu aufgeklärt. Die Anwesenheit von hEag1 in Tumoren hat zu einem Anstieg in Verbindung gebracht worden in Proliferation.
Gomes, Fernanda Ramos +5 more
openaire +3 more sources
Frontiers in Pharmacology, 2020 EAG (ether-à-go-go or KCNH) are a subfamily of the voltage-gated potassium (Kv) channels. Like for all potassium channels, opening of EAG channels drives the membrane potential toward its equilibrium value for potassium, thus setting the resting ...
Francisco Barros +4 more
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