Results 11 to 20 of about 20,804 (181)
Electrocardiogram abnormalities in patients with acne undergoing isotretinoin therapy: a focused review [PDF]
Anais Brasileiros de DermatologiaIsotretinoin is an extremely successful treatment for acne, widely prescribed for moderate to severe cases unresponsive to conventional therapy that is commonly used in dermatology.
Afra Wasama Islam +4 more
doaj +3 more sources
Human ether-à-go-go gene potassium channels are regulated by EGFR tyrosine kinase
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Human ether á-go-go gene potassium channels (hEAG1 or Kv10.1) are expressed in brain and various human cancers and play a role in neuronal excitement and tumor progression. However, the functional regulation of hEAG channels by signal transduction is not fully understood.
Tse, HF +6 more
openaire +5 more sources
Discovery of a novel broad-spectrum inhibitor against influenza virus A [PDF]
Virology JournalThe pandemic of influenza A virus (IAV) is on the rise worldwide, however, drug resistance to anti-influenza drugs has been widely found. The viral mutation of IAV highlights the necessitate for discovery of new antiviral agents with broad-spectrum ...
Ran Yu, Peng Li, Rong Shen, Wenting Fei
doaj +2 more sources
Case report: Ivabradine induced Torsades de Pointes
IHJ Cardiovascular Case Reports, 2023 Ivabradine is used to control heart rate in patients of heart failure with reduced ejection fraction. Although considered safe, it is reported to prolong QTc interval when given with other QTc prolonging drugs or in setting of hypokalemia or ...
Mohit M. Bhagwati +2 more
doaj +1 more source
Toxins, 2021 The Colombian scorpion Centruroides margaritatus produces a venom considered of low toxicity. Nevertheless, there are known cases of envenomation resulting in cardiovascular disorders, probably due to venom components that target ion channels. Among them,
José Beltrán-Vidal +7 more
doaj +1 more source
Neurobiology of Disease, 2020 Environmental toxicants have the potential to contribute to the pathophysiology of multiple complex diseases, but the underlying mechanisms remain obscure.
Jenna Harrigan +4 more
doaj +1 more source
Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging [PDF]
Analytical Chemistry, 2015 The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off-on mechanism was described herein. After careful biological evaluation, this probe had the potential of detecting and imaging the hERG channel at the molecular and cellular level ...
Liu, Zhenzhen +5 more
openaire +2 more sources
Ether à go-go potassium channel expression in soft tissue sarcoma patients [PDF]
Molecular Cancer, 2006 Abstract Background The expression of the human Eag1 potassium channel (Kv10.1) is normally restricted to the adult brain, but it has been detected in both tumour cell lines and primary tumours. Our purpose was to determine the frequency of expression of Eag1 in soft tissue sarcoma and its potential clinical ...
Mello de Queiroz, Fernanda +3 more
openaire +5 more sources
Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1
Scientific Reports, 2022 Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has been a growing
Nirakar Sahoo +11 more
doaj +1 more source