Results 61 to 70 of about 20,804 (181)

Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels*

Journal of Biological Chemistry, 2016
Cardiac long QT syndrome type 2 is caused by mutations in the human ether a go-go-related gene (hERG) potassium channel, many of which cause misfolding and degradation at the endoplasmic reticulum instead of normal trafficking to the cell surface.
Christine Hantouche, B. Williamson, William C. Valinsky, Joshua Solomon, A. Shrier, J. Young   +5 more
semanticscholar   +1 more source

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator [PDF]

Proceedings of the National Academy of Sciences, 2007
Activation of human ether-a-go-go-related gene 1 (hERG1) K + channels mediates cardiac action potential repolarization. Drugs that activate hERG1 channels represent a mechanism-based approach for the treatment of long QT syndrome, a disorder of cardiac repolarization associated with ...
Matthew, Perry, Frank B, Sachse, Michael C, Sanguinetti   +2 more
openaire   +2 more sources

Molecular basis of slow activation of the human ether‐á‐go‐go related gene potassium channel [PDF]

The Journal of Physiology, 2004
The human ether‐á‐go‐go related gene (HERG) encodes the pore forming α‐subunit of the rapid delayed rectifier K+ channel which is central to the repolarization phase of the cardiac action potential. HERG K+ channels have unusual kinetics characterized by slow activation and deactivation, yet rapid inactivation.
Rajesh N, Subbiah, Catherine E, Clarke, David J, Smith, JingTing, Zhao, Terence J, Campbell, Jamie I, Vandenberg   +5 more
openaire   +2 more sources

Voltage-dependent gating of hERG potassium channels

Frontiers in Pharmacology, 2012
The mechanisms by which voltage-gated channels sense changes in membrane voltage and energetically couple this with opening of the ion conducting pore has been the source of significant interest.
Yen May eCheng, Tom W Claydon
doaj   +1 more source

Human Ether á-go-go Gene Potassium Channels Are Regulated by EGFR Tyrosine Kinase [PDF]

Biophysical Journal, 2009
Human ether á-go-go gene potassium channels (hEAG1) are expressed in brain and several types of human cancers and play a critical role in neuronal excitement and tumor progression. However, functional regulation of hEAG1 channels is not understood. The present study was designed to determine whether hEAG1 channels are regulated by EGFR kinase in HEK ...
Lau, CP, Tse, HF, Li, GR, Wu, W
openaire   +2 more sources

Targeting the Ether-à-go-go ion channels in cancer therapy: current knowledge and future perspectives

Journal of Experimental and Molecular Biology, 2018
Members of the Ether-à-go-go (Eag) group of potassium channels, including the human Ether-à-go-go (hEag) and the human Ether-à-go-go-related gene (hERG) ion channels, have been shown to play important roles in cancer pathogenesis and to regulate many ...
Daniel Şterbuleac, Dumitru Cojocaru
doaj  

Potassium dependent structural changes in the selectivity filter of HERG potassium channels

Nature Communications
The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go related gene (HERG) potassium channels have uniquely rapid
Carus H. Y. Lau, Emelie Flood, Mark J. Hunter, Billy J. Williams-Noonan, Karen M. Corbett, Chai-Ann Ng, James C. Bouwer, Alastair G. Stewart, Eduardo Perozo, Toby W. Allen, Jamie I. Vandenberg   +10 more
doaj   +1 more source

Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study

Behavioral and Brain Functions, 2010
Background The pathobiology of schizophrenia is still unclear. Its current treatment mainly depends on antipsychotic drugs. A leading adverse effect of these medications is the acquired long QT syndrome, which results from the blockade of cardiac HERG1 ...
Ozbek Ugur, Yesilbursa Dogan, Oncu Fatih, Cine Naci, Acuner Tufan, Atalar Fatmahan, Turkcan Solmaz   +6 more
doaj   +1 more source

Risk of QTc Interval Prolongation Associated With Circulating Anti‐Ro/SSA Antibodies Among US Veterans: An Observational Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Anti‐Sjögren's syndrome‐related antigen A‐antibodies (anti‐Ro/SSA‐antibodies) are responsible for a novel form of acquired long‐QT syndrome, owing to autoimmune‐mediated inhibition of cardiac human ether‐a‐go‐go‐related gene‐potassium channels.
Pietro Enea Lazzerini, Gabriele Cevenini, Yongxia Sarah Qu, Frank Fabris, Nabil El‐Sherif, Maurizio Acampa, Alessandra Cartocci, Franco Laghi‐Pasini, Pier Leopoldo Capecchi, Mohamed Boutjdir, Deana Lazaro   +10 more
doaj   +1 more source

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Drug Design, Development and Therapy, 2015
Nadine Vonderlin,1 Fathima Fischer,1 Edgar Zitron,1,2 Claudia Seyler,1 Daniel Scherer,1 Dierk Thomas,1,2 Hugo A Katus,1,2 Eberhard P Scholz1 1Department of Internal Medicine III, University Hospital Heidelberg, 2German Centre for Cardiovascular ...
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,   +7 more
doaj