Results 81 to 90 of about 20,804 (181)

Overexpression of potassium channel ether à go-go in human osteosarcoma

Neoplasma, 2012
Human ether à go-go (hEAG) potassium channels are primarily expressed in brain but also frequently overexpressed in solid tumors, which could indicate their potential value for cancer diagnosis and therapy. hEAG1, one member of the hEAG subfamily, has been shown to play a role in neoplastic process.
J, Wu, X, Wu, K, Lian, B, Lin, L, Guo, Z, Ding   +5 more
openaire   +3 more sources

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

BMC Genetics, 2018
Background Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response ...
Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters, Torben Hansen   +15 more
doaj   +1 more source

Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel

Journal of Pharmacological Sciences, 2019
The human ether-a-go-go-related gene (hERG) encodes the K+ channel that carries the rapid component of the delayed rectifier current in the human heart. Reduction of hERG activity induced by gene mutations or pharmacological inhibition is responsible for the type 2 form of long QT syndrome in patients which can develop into ventricular arrhythmia and ...
Xiuming Dong, Yani Liu, Heling Niu, Gongxin Wang, Liying Dong, Anruo Zou, KeWei Wang   +6 more
openaire   +3 more sources

Evaluation of cardiac arrhythmia incidence in patients treated with oral moxifloxacin

International Journal of the Cardiovascular Academy, 2019
Background: The effect of moxifloxacin on QT interval is reversible and dose related, mainly provided by weakly but rapidly activated rectifying potassium channel blockade, IKr or human ether-a-go-go-related gene potassium channels.
Casit Olgun Celik, Aylin Yıldırır, Kaan Okyay, İlyas Atar, Mehmet Bülent Özin, İbrahim Haldun Müderrisoğlu   +5 more
doaj   +1 more source

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Frontiers in Physiology, 2019
Short QT syndrome variant 1 (SQT1) arises due to gain-of-function mutations to the human Ether-à-go-go-Related Gene (hERG), which encodes the α subunit of channels carrying rapid delayed rectifier potassium current, IKr.
Dominic G. Whittaker, Dominic G. Whittaker, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang, Henggui Zhang   +7 more
doaj   +1 more source

Modeling the Impact of Temperature on the Electrical Activity of Cardiac Cells: Identification of Key Ionic Currents

Mìkrosistemi, Elektronìka ta Akustika
This study presents the development of a modified electrophysiological model of a human epicardial cardiomyocyte, achieved by taking into account the temperature effects on the kinetics and conductance of ion channels using parameter-specific Q10 ...
Vitalii O. Ivashchuk, Nataliia Heorhiivna Ivanushkina   +1 more
doaj   +1 more source

Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma

Biologics: Targets & Therapy, 2016
María de Guadalupe Chávez-López,1 Violeta Zúñiga-García,1 Julio Isael Pérez-Carreón,2 Arturo Avalos-Fuentes,3 Yesenia Escobar,4 Javier Camacho1 1Department of Pharmacology, Centro de Investigaci ...
Chávez-López MG, Zúñiga-García V, Pérez-Carreón JI, Avalos-Fuentes A, Escobar Y, Camacho J   +5 more
doaj  

Erg currents support electrical bursting in murine anterior pituitary corticotrophs. [PDF]

J Physiol
Nair SV, Romanò N, Duncan PJ, Tissier PL, Bertram R, Shipston MJ.   +5 more
europepmc   +1 more source

Biomimetic action-potential transmission via mechano-gated potassium channels assembled by quadruple hydrogen-bonded crown ethers. [PDF]

Sci Adv
Li C, Chen C, Shi J, Han W, Fu Q, Yang L.   +5 more
europepmc   +1 more source

Ultrathin crown ether-based polyamide membrane for ion-ion separations. [PDF]

Nat Commun
Villalobos LF, Zhang J, Lee J, Hall AT, DuChanois RM, Violet C, Cumings J, Zhong M, Elimelech M.   +8 more
europepmc   +1 more source