Results 71 to 80 of about 20,804 (181)

Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation

Journal of Pharmacological Sciences, 2015
The human ether-a-go-go-related gene (HERG) potassium current (IHERG) has been shown to decrease in amplitude following stimulation with Gq protein-coupled receptors (GqRs), such as α1-adrenergic and M1-muscarinic receptors (α1R and M1R, respectively ...
Taeko Kubo, Wei-Guang Ding, Futoshi Toyoda, Yusuke Fujii, Mariko Omatsu-Kanbe, Hiroshi Matsuura   +5 more
doaj   +1 more source

Identification of a COOH-terminal Segment Involved in Maturation and Stability of Human Ether-a-go-go-related Gene Potassium Channels*

Journal of Biological Chemistry, 2003
Mutations in the potassium channel encoded by the human ether-a-go-go-related gene (HERG) have been linked to the congenital long QT syndrome (LQTS), a cardiac disease associated with an increased preponderance of ventricular arrhythmias and sudden death.
Armin Akhavan, R. Atanasiu, A. Shrier
semanticscholar   +1 more source

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain

Journal of Biological Chemistry, 2016
The ether à go-go family of voltage-gated potassium channels is structurally distinct. The N terminus contains an eag domain (eagD) that contains a Per-Arnt-Sim (PAS) domain that is preceded by a conserved sequence of 25–27 amino acids known as the PAS ...
É. Lörinczi, Matthew V. Helliwell, A. Finch, P. Stansfeld, N. Davies, M. Mahaut-Smith, F. Muskett, J. Mitcheson   +7 more
semanticscholar   +1 more source

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels

BMC Pharmacology and Toxicology, 2019
Background KCNH family of potassium channels is responsible for diverse physiological functions ranging from the regulation of neuronal excitability and cardiac contraction to the regulation of cancer progression. KCNH channels contain a Per-Arn-Sim (PAS)
Ze-Jun Wang, Purushottam B. Tiwari, Aykut Üren, Tinatin I. Brelidze   +3 more
doaj   +1 more source

Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Centruroides hirsutipalpus, of the family Buthidae, is a scorpion endemic to the Western Pacific region of Mexico. Although medically important, its venom has not yet been studied.
Laura L. Valdez-Velázquez, Timoteo Olamendi-Portugal, Rita Restano-Cassulini, Fernando Z. Zamudio, Lourival D. Possani   +4 more
doaj   +1 more source

Functional characterization of ether-a-go-go-related gene potassium channels in midbrain dopamine neurons: implications for a role in depolarization block

European Journal of Neuroscience, 2012
Bursting activity by midbrain dopamine neurons reflects the complex interplay between their intrinsic pacemaker activity and synaptic inputs. Although the precise mechanism responsible for the generation and modulation of bursting in vivo has yet to be ...
H. Ji, K. Tucker, Ilva Putzier, M. Huertas, J. Horn, C. Canavier, E. Levitan, P. D. Shepard   +7 more
semanticscholar   +1 more source

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

PLoS ONE, 2019
The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines.
Damodara Reddy Vaddi, Lin Piao, Shakil A Khan, Ning Wang, Nanduri R Prabhakar, Jayasri Nanduri   +5 more
doaj   +1 more source

Tumor cell-selective apoptosis induction through targeting of K_V10.1 via bifunctional TRAIL antibody

Molecular Cancer, 2011
Background The search for strategies to target ion channels for therapeutic applications has become of increasing interest. Especially, the potassium channel KV10.1 (Ether-á-go-go) is attractive as target since this surface protein is virtually not ...
Pardo Luis A, Stühmer Walter, Hartung Franziska   +2 more
doaj   +1 more source

Development of models for predicting Torsade de Pointes cardiac arrhythmias using perceptron neural networks

BMC Bioinformatics, 2017
Background Blockage of some ion channels and in particular, the hERG (human Ether-a’-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia.
Mohsen Sharifi, Dan Buzatu, Stephen Harris, Jon Wilkes   +3 more
doaj   +1 more source

Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

Journal of Arrhythmia, 2016
Background: The human ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly activating delayed-rectifier potassium channels. Mutations in this gene cause long QT syndrome type 2 (LQT2).
Takehito Kondo, Ichiro Hisatome, Shouichi Yoshimura, Endang Mahati, Tomomi Notsu, Peili Li, Kazuhiko Iitsuka, Masaru Kato, Kazuyoshi Ogura, Junichiro Miake, Takeshi Aiba, Wataru Shimizu, Yasutaka Kurata, Shinji Sakata, Naoe Nakasone, Haruaki Ninomiya, Akira Nakai, Katsumi Higaki, Yasushi Kawata, Yasuaki Shirayoshi, Akio Yoshida, Kazuhiro Yamamoto   +21 more
doaj   +1 more source