Results 51 to 60 of about 20,804 (181)

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

BMC Molecular and Cell Biology, 2021
Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1.
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada, Masanori Osawa   +14 more
doaj   +1 more source

Anti-Ro/SSA Antibodies and the Autoimmune Long-QT Syndrome

Frontiers in Medicine, 2021
Autoimmunity is increasingly recognized as a novel pathogenic mechanism for cardiac arrhythmias. Several arrhythmogenic autoantibodies have been identified, cross-reacting with different types of surface proteins critically involved in the cardiomyocyte ...
Pietro Enea Lazzerini, Franco Laghi-Pasini, Mohamed Boutjdir, Mohamed Boutjdir, Pier Leopoldo Capecchi   +4 more
doaj   +1 more source

The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia [PDF]

Molecular Cancer, 2010
AbstractBackgroundThe voltage-gated potassium channel hEag1 (KV10.1) has been related to cancer biology. The physiological expression of the human channel is restricted to the brain but it is frequently and abundantly expressed in many solid tumors, thereby making it a promising target for a specific diagnosis and therapy.
Agarwal, Jasmin R., Griesinger, Frank, Stühmer, Walter, Pardo, Luis A.   +3 more
openaire   +5 more sources

14-3-3θ is a binding partner of rat Eag1 potassium channels. [PDF]

PLoS ONE, 2012
The ether-à-go-go (Eag) potassium (K(+)) channel belongs to the superfamily of voltage-gated K(+) channel. In mammals, the expression of Eag channels is neuron-specific but their neurophysiological role remains obscure.
Po-Hao Hsu, Shi-Chuen Miaw, Chau-Ching Chuang, Pei-Yu Chang, Ssu-Ju Fu, Guey-Mei Jow, Mei-Miao Chiu, Chung-Jiuan Jeng   +7 more
doaj   +1 more source

Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel [PDF]

Cardiovascular Research, 2000
To evaluate the effects of azimilide and ambasilide on the biophysical properties of the human-ether-a-go-go-related (HERG) channel.HERG was stably transfected into Chinese hamster ovary (CHO-K1) cells and currents were measured using a whole cell, voltage-clamp technique.Azimilide had a 'dual effect', inhibiting current at voltage steps above -40 mV ...
B D, Walker, C B, Singleton, H, Tie, J A, Bursill, K R, Wyse, S M, Valenzuela, S N, Breit, T J, Campbell   +7 more
openaire   +2 more sources

In silico mechanisms of arsenic trioxide-induced cardiotoxicity

Frontiers in Physiology, 2022
It has been found that arsenic trioxide (ATO) is effective in treating acute promyelocytic leukemia (APL). However, long QT syndrome was reported in patients receiving therapy using ATO, which even led to sudden cardiac death.
Yacong Li, Runlan Wan, Jun Liu, Jun Liu, Weichao Liu, Lei Ma, Lei Ma, Henggui Zhang   +7 more
doaj   +1 more source

Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines [PDF]

World Journal of Gastroenterology, 2007
To study the expression of ether à go-go (Eag1) potassium channel in colorectal cancer and the relation-ship between their expression and clinico-pathological features.The expression levels of Eag1 protein were determined in 76 cancer tissues with paired non-cancerous matched tissues as well as 9 colorectal adenoma tissues by immunohistochemistry. Eag1
Xiang-Wu, Ding, Juan-Juan, Yan, Ping, An, Peng, Lü, He-Sheng, Luo   +4 more
openaire   +2 more sources

Expression of the ether-a-gò-gò-related gene 1 channel during B and T lymphocyte development: role in BCR and TCR signaling

Frontiers in Immunology, 2023
The functional relevance of K+ and Ca2+ ion channels in the “Store Operated Calcium Entry” (SOCE) during B and T lymphocyte activation is well proven. However, their role in the process of T- and B- cell development and selection is still poorly defined.
Cesare Sala, Martina Staderini, Tiziano Lottini, Claudia Duranti, Gabriele Angelini, Gabriela Constantin, Annarosa Arcangeli   +6 more
doaj   +1 more source

p38 MAPK regulates the expression of ether à go-go potassium channel in human osteosarcoma cells [PDF]

Radiology and Oncology, 2013
Abstract Background. The ether à go-go (Eag) channel has been shown to be overexpressed in a variety of cancers. However, the expression and function of Eag in osteosarcoma are poorly understood. In addition, the molecular mechanisms responsible for Eag overexpression in cancer cells remain unclear. Methods.
Wu, Xinyu, Zhong, Daixing, Lin, Bin, Zhai, Wenliang, Ding, Zhenqi, Wu, Jin   +5 more
openaire   +2 more sources

Astemizole inhibits cell proliferation in human prostate tumorigenic cells expressing ether à-go-go-1 potassium channels.

Cellular and Molecular Biology, 2017
Prostate cancer (PC) is the main cause of cancer mortality in men worldwide. Therefore, novel treatments for PC are needed. Ether à-go-go-1 (Eag1) potassium channels display oncogenic properties, and have been suggested as early tumor markers and ...
Gloria Bernal-Ramos, E. Hernández-Gallegos, Eunice Vera, María de Guadalupe Chávez-López, V. Zúñiga-García, Y. Sánchez-Pérez, E. Garrido, J. Camacho   +7 more
semanticscholar   +1 more source