Results 61 to 70 of about 313 (129)

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Long QT Syndrome Type 2: Emerging Strategies for Correcting Class 2 KCNH2 (hERG) Mutations and Identifying New Patients

Biomolecules, 2020
Significant advances in our understanding of the molecular mechanisms that cause congenital long QT syndrome (LQTS) have been made. A wide variety of experimental approaches, including heterologous expression of mutant ion channel proteins and the use of
Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle   +9 more
doaj   +1 more source

Long QT Syndrome Type 5 With Coexisting KCNE1 and RYR2 Variants: A Diagnostic Ambiguity

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Long QT syndrome (LQTS) predisposes to syncope and sudden cardiac death. Type 5 LQTS, linked to KCNE1 variants, is rare. A teenage female presented with recurrent syncope. ECG showed QTc 485 ms. Genetic testing identified KCNE1 and RYR2 variants. Beta‐blockers and ICD prevented events.
Mohammad Hossein Nikoo, Hossein Fatemian, Amir Hossein Hassani, Mehrdad Rabiee Rad, Sara Mostafavi   +4 more
wiley   +1 more source

A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6

Case Reports in Medicine, 2019
We report a 37-year-old woman with an out-of-hospital cardiac arrest caused by ventricular fibrillation due to digenic inheritance of long QT syndrome type 2 (KCNH2 gene) and type 6 (KCNE2 gene).
Annejet Heida, Lisette J. M. E. van der Does, Ahmed A. Y. Ragab, Natasja M. S. de Groot   +3 more
doaj   +1 more source

From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi‐Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death

Clinical Cardiology, Volume 49, Issue 6, June 2026.
An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam, Mohammad Hosein Yazdanpanah, Narges Fereydouni   +2 more
wiley   +1 more source

AI-driven network pharmacology and multi-omics validation identify KCNH2 as a prognostic biomarker and candidate therapeutic vulnerability of Acorus tatarinowii in glioblastoma

Frontiers in Pharmacology
BackgroundGlioblastoma (GBM) remains a highly aggressive malignancy with limited effective therapeutic options. Integrating traditional medicine resources with artificial intelligence–based analytical strategies may accelerate the identification of novel
Xiaoqing Song, Yuanyang Xiao, Junhui Liu, Shanshan Wei, Meijuan Tan, Yuanyuan Chen, Xiaohong Yu   +6 more
doaj   +1 more source

Generation and characterization of an induced pluripotent stem cell (iPSC) line (NUIGi003-A) from a long QT syndrome type 2 (LQT2) patient harbouring the KCNH2 c.2464G>A pathogenic variant

Stem Cell Research, 2020
Long QT syndrome (LQTS), an inherited cardiac ion channelopathy, is associated with ventricular arrhythmias and risk of sudden death. LQTS sub-type 2 (LQT2) is caused by pathogenic variants in KCNH2 encoding the α-subunit of Kv11.1, thus affecting the ...
Ning Ge, Min Liu, Janusz Krawczyk, Veronica McInerney, Deirdre Ward, Sanbing Shen, Timothy O'Brien, Terence Prendiville   +7 more
doaj   +1 more source

Torsades de Pointes electrical storm in children with KCNH2 mutations

BMC Medical Genomics
Congenital long QT syndrome (LQTS) is a genetic heart disorder, which may lead to life-threatening arrhythmias, especially in children. Here, we reported two children who were initially misdiagnosed with epilepsy and experienced Torsades de Pointes (TdP) cardiac electrical storm (ES).
Li Zhang, Meng Xu, Zhen Yan, Yan Han, Xunwei Jiang, Tingting Xiao, Cuilan Hou, Yun Li   +7 more
openaire   +3 more sources

Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome.

PLoS ONE
We identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first mutation was in a 1-day-old infant, whereas the second was in a 14-year-old girl.
Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M Cordeiro, Makarand Deo   +9 more
doaj   +1 more source

KCNH2 pharmacogenomics summary [PDF]

Pharmacogenetics and Genomics, 2010
Connie, Oshiro, Caroline F, Thorn, Dan M, Roden, Teri E, Klein, Russ B, Altman   +4 more
openaire   +2 more sources