Results 51 to 60 of about 6,642 (199)

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2 [PDF]

, 2014
Please cite as follows: Christiansen, M. et al. 2014. Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2.
Pedersen, Lisbeth N, Aidt, Frederik H, Bloch Thomsen, Poul E., Hedley, Paula L., Stoevring, Birgitte, Aidt, Frederik H., Ousager, Lilian Bomme, Jensen, Henrik Kjærulf, Christiansen, Michael, Leren, Trond P, Sørensen, Karina M., Aidt, Frederik Heurlin, Bundgaard, Henning, Henriksen, Finn L, Kanters, Jørgen K, Tybjærg-Hansen, Anne, Eschen, Ole, Hansen, Michael G., Theilade, Juliane, Hansen, Michael G, Frikke-Schmidt, Ruth, Hansen, Jim, Jensen, Henrik K, Ousager, Lilian B., Sørensen, Karina M, Kanters, Jorgen K., Ousager, Lilian Bomme; id_orcid, Hedley, Paula L, Pedersen, Lisbeth N., Henriksen, Finn Lund, Toft, Egon, Kanters, Jørgen K., Leren, Trond P., Henriksen, Finn L., Thomsen, Poul Erik Bloch, Bloch Thomsen, Poul E, Jensen, Henrik K., Lisbeth N Pedersen, Frederik H Aidt, Henrik K Jensen, Henning Bundgaard, Lilian B Ousager, Finn L Henriksen, Michael G Hansen, Egon Toft, Anne Tybjærg-Hansen, Juliane Theilade, Ruth Frikke-Schmidt, Paula L Hedley, Birgitte Stoevring, Ole Eschen, Poul E Bloch Thomsen, Jim Hansen, Trond P Leren, Jørgen K Kanters, Karina M Sørensen, Michael Christiansen   +56 more
core   +2 more sources

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia

, 2009
Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5′ complementary DNA ends in human brain, we identified a primate-specific isoform (3.1) of the ether-a-go-go-related K+ channel ...
Feng Yang, Karine Mayilyan, Weinberger D. R., Yang F., Mayilyan, Karine, Venkata Mattay, Huffaker, Stephen J, Giegling, Ina, Daniel R Weinberger, Lu, Bai, Mayilyan K., Lipska, Barbara K, Ji Y., Chen, Jingshan, Ina Giegling, Grazia Caforio, Meyer Lindenberg, Andreas, Fabio Sambataro, Song J., Nicodemus, Kristin K, Morgan J Proust, Hyde, Thomas M, Jingshan Chen, Joseph H Callicott, Callicott J. H., Egan M. F., Bai Lu, Huffaker S. J., Michael F Egan, Yang, Feng, Callicott, Joseph H, Hyde T. M., Stephen J Huffaker, Goldberg T. E., Proust, Morgan J, Yuanyuan Ji, Soghoyan, Armen, Proust M. J., Andreas Meyer-Lindenberg, Dan Rujescu, Barbara K Lipska, Chang J., SAMBATARO, Fabio, Kristin K Nicodemus, Meyer-Lindenberg A., Lipska B. K., Thomas M Hyde, Soghoyan A., Caforio G., Egan, Michael F, Ji, Yuanyuan, Armen Soghoyan, Rujescu D., Lu B., Bertolino A., Bertolino, Alessandro, Caforio, Grazia, Chen J., Kleinman J. E., Song, Jian, Alessandro Bertolino, Jian Song, Mattay V., Terry E Goldberg, Joel E Kleinman, Goldberg, Terry E, Giegling I., Mattay, Venkata, Sambataro F., Chang, Jay, Nicodemus K. K., Rujescu, Dan, Weinberger, Daniel R., Kleinman, Joel E, Jay Chang   +74 more
core   +1 more source

The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG).

, 2008
AIMS: Atrial fibrillation (AF) is the most frequent arrhythmia in humans. Rare familial forms exist. Recent evidence indicates a genetic susceptibility to common forms of AF.
Sinner, MF;Pfeufer, A;Akyol, M;Beckmann, BM;Hinterseer, M;Wacker, A;Perz, S;Sauter, W;Illig, T;Näbauer, M;Schmitt, C;Wichmann, HE;Schömig, A;Steinbeck, G;Meitinger, T;Kääb, S
core   +2 more sources

Identifying genomic variant associated with long QT syndrome type 2 in an ecuadorian mestizo individual: a case report

Frontiers in Genetics
IntroductionLong QT syndrome (LQTS) is an autosomal dominant inherited cardiac condition characterized by a QT interval prolongation and risk of sudden death. There are 17 subtypes of this syndrome associated with genetic variants in 11 genes. The second
Rafael Tamayo-Trujillo, Rita Ibarra-Castillo, José Luis Laso-Bayas, Patricia Guevara-Ramirez, Santiago Cadena-Ullauri, Elius Paz-Cruz, Viviana A. Ruiz-Pozo, Nieves Doménech, Adriana Alexandra Ibarra-Rodríguez, Ana Karina Zambrano   +9 more
doaj   +1 more source

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

The Journal of Physiology, EarlyView.
Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Aborted Cardiac Arrest in LQT2 Related to Novel KCNH2 (hERG) Variant Identified in One Lithuanian Family [PDF]

, 2021
Congenital long QT syndrome (LQTS) is a hereditary ion channelopathy associated with ventricular arrhythmia and sudden cardiac death starting from young age due to prolonged cardiac repolarization, which is represented by QT interval changes in ...
Utkus, Algirdas,, Marinskis, Germanas,, Mikštienė, Violeta,, Eglė Preikšaitienė, Monika Keževičiūtė, Preikšaitienė, Eglė,, Bileišienė, Neringa,, Algirdas Utkus, Audrius Aidietis, Barysienė, Jūratė,, Violeta Mikštienė, Neringa Bileišienė, Aidietis, Audrius,, Germanas Marinskis, Jūratė Barysienė, Keževičiūtė, Monika,   +15 more
core   +1 more source