Results 51 to 60 of about 1,208,260 (137)

Possible roles of the weakly inward rectifying K(+) channel Kir4.1 (KCNJ10) in the pre-Botzinger complex

, 2008
Rhythmic activity of respiratory neurons is dependent on the clearance of neurotransmitter by astrocytes. Astrocytes should also be involved in the permanent and rapid clearance of extracellular ions.
Huelsmann, Swen, Kaiser, Melanie, Neusch, Clemens, Papadopoulos, Nestoras, Haertel, Kai, Winter, Stefan M.   +5 more
core   +2 more sources

Role of Kir4.1 Channel in Auditory Function: Impact on Endocochlear Potential and Hearing Loss

Applied Sciences
Hearing loss can result from impairments in structures that support endocochlear potential, as they play a crucial role in the transduction and transmission of auditory waves. This aspect has been the subject of several studies to date.
Silvia Fracaro, Filippo Hellies, Gino Marioni, Davide Brotto, Sebastiano Franchella, Elisabetta Zanoletti, Giovanna Albertin, Laura Astolfi   +7 more
doaj   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State

Glia, Volume 74, Issue 1, January 2026.
THY1‐bearing neurons keep astrocytes in a quiescent state via the interaction with ITGB1. Depletion of THY1 supports the development of a partially activated astrocyte phenotype. Neuronal THY1 is involved in the maintenance and restoration of tissue homeostasis in the brain. ABSTRACT THY1 is a cell surface protein of mature neurons.
Juliane Loui, Ute Krügel, Ulrike Winkler, Anja Reinert, Dorit John, Johannes Hirrlinger, Anja Saalbach   +6 more
wiley   +1 more source

The Selective Bromodomain and Extra‐Terminal Domain (BET) Inhibitor RVX‐208 Reduces Cocaine‐Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens

Addiction Biology, Volume 31, Issue 1, January 2026.
Rats treated with the domain‐selective BET inhibitor RVX‐208 during a 2‐week forced abstinence period exhibited a reduction in cocaine‐seeking behaviour but not sucrose seeking or open field behaviour. This treatment effect was associated with proteomic changes in pathways relevant to dopaminergic and glutamatergic signalling in the nucleus accumbens ...
Tyler J. Sacko, Afshin Seyednejad, Jesse Engelhardt, Gregory C. Sartor   +3 more
wiley   +1 more source

KCNJ10 Mutations Disrupt Function in Patients with EAST Syndrome

, 2011
<i>Background/Aims:</i> Mutations in the inwardly-rectifying K⁺ channel KCNJ10/Kir4.1 cause an autosomal recessive disorder characterized by epilepsy, ataxia, sensorineural deafness and tubulopathy (EAST syndrome ...
Louise Brueton, Nathalie Dorison, Robert Kleta, Markus Reichold, Duvaraka Kulaveerasingam, Detlef Bockenhauer, Lokesh Lingappa, Evangeline Wassmer, Anselm A. Zdebik, Mehul A. Shah, Milos Ognjanovic, Bernard Freudenthal   +11 more
core   +1 more source

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, Volume 59, Issue 1, January 2026.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations

, 2016
Background: Five children from two consanguineous families presented with epilepsy beginning in infancy and severe ataxia, moderate sensorineural deafness, and a renal salt-losing tubulopathy with normotensive hypokalemic metabolic alkalosis.
Zdebik, Anselm A., Sterner, Christina, Lieberer, Evelyn, Anikster, Yair, Reichold, Markus, Gahl, William A., Bandulik, Sascha, Stanescu, Horia C., Tobin, Jonathan, Landoure, Guida, Bockenhauer, Detlef, Arcos-Burgos, Mauricio, Feather, Sally   +12 more
core   +1 more source

Pathophysiologie der p.A167V-Mutation von KCNJ10 [PDF]

, 2016
KCNJ10 ist ein einwärtsgleichrichtender Kaliumkanal, der in der Niere, im ZNS und im Innenohr exprimiert wird. In der Niere kommt er als Heteromer mit KCNJ16, einem verwandten Kanalprotein, vor.
Tondorf, Felizitas
core   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source