Results 71 to 80 of about 3,372 (135)

MiR-1/133 attenuates cardiomyocyte apoptosis and electrical remodeling in mice with viral myocarditis

Cardiology Journal, 2020
BACKGROUND: The role of miR-1 and miR-133 in regulating the expression of potassium and calcium ion channels, and mediating cardiomyocyte apoptosis in mice with viral myocarditis (VMC) is investigated herein.
Wei Li, Mengmeng Liu, Cuifen Zhao, Cai Chen, Qingyu Kong, Zhifeng Cai, Dong Li   +6 more
doaj   +1 more source

Long QT molecular autopsy in sudden unexplained death in the young (1-40 years old): Lessons learnt from an eight year experience in New Zealand.

PLoS ONE, 2018
BackgroundTo review long QT syndrome molecular autopsy results in sudden unexplained death in young (SUDY) between 2006 and 2013 in New Zealand.MethodsAudit of the LQTS molecular autopsy results, cardiac investigations and family screening data from gene-
Luciana Marcondes, Jackie Crawford, Nikki Earle, Warren Smith, Ian Hayes, Paul Morrow, Tom Donoghue, Amanda Graham, Donald Love, Jonathan R Skinner, Cardiac Inherited Disease Group New Zealand   +10 more
doaj   +1 more source

Idiopathic Generalized Epilepsy and Hypokalemic Periodic Paralysis in a Family of South Indian Descent

Case Reports in Neurological Medicine, 2015
Inherited channelopathies are a heterogeneous group of disorders resulting from dysfunction of ion channels in cellular membranes. They may manifest as diseases affecting skeletal muscle contraction, the conduction system of the heart, nervous system ...
Muthiah Subramanian, N. Senthil, S. Sujatha   +2 more
doaj   +1 more source

Nova mutacija kanalčka KCNJ2 pri bolnici s sindromom Andersen-Tawil

Zdravniški Vestnik, 2013
Andersen-Tawil syndrome (ATS) is a rare inherited or sporadic disorder characterized by ventricular arrhythmias, characteristic QT-U wave patterns in electrocardiogram, periodic paralysis, and dysmorphic features.
Matjaž Šinkovec, Andrej Pernat, Matevž Jan, Bor Antolič, Jernej Kovač, Katarina Trebušak Podkrajšek, Maruša Debeljak   +6 more
doaj  

Familial hypokalemic periodic paralysis: a case induced by concurrent hyperthyroidism

BMC Nephrology
Background Familial hypokalemic periodic paralysis (HypoPP) is an uncommon genetic disorder characterized by recurrent episodes of muscle weakness and hypokalemia, typically starting in early adulthood. The existence of hyperthyroidism in the presence of
Zein Alabdin Hannouneh, C. Elena Cervantes, C. John Sperati, Mohamad Hanouneh   +3 more
doaj   +1 more source

Characterization of a novel KCNJ2 sequence variant detected in Andersen-Tawil syndrome patients

BMC Medical Genetics, 2017
Background Mutations in the KCNJ2 gene encoding the ion channel Kir2.1 have been linked to the Andersen-Tawil syndrome (ATS). Molecular genetic screening performed in a family exhibiting clinical ATS phenotypes unmasked a novel sequence variant (c.434A > 
Stefanie Scheiper, Brigitte Hertel, Britt-Maria Beckmann, Stefan Kääb, Gerhard Thiel, Silke Kauferstein   +5 more
doaj   +1 more source

Breast Cancer Clinical Trial of Chemotherapy and Trastuzumab: Potential Tool to Identify Cardiac Modifying Variants of Dilated Cardiomyopathy

Journal of Cardiovascular Development and Disease, 2017
Doxorubicin and the ERBB2 targeted therapy, trastuzumab, are routinely used in the treatment of HER2+ breast cancer. In mouse models, doxorubicin is known to cause cardiomyopathy and conditional cardiac knock out of Erbb2 results in dilated ...
Daniel J. Serie, Julia E. Crook, Brian M. Necela, Bianca C. Axenfeld, Travis J. Dockter, Gerardo Colon-Otero, Edith A. Perez, E. Aubrey Thompson, Nadine Norton   +8 more
doaj   +1 more source

Clinical, myopathological, and genetic features of two Chinese families with Andersen-Tawil syndrome

Frontiers in Neurology
PurposeTo explore the clinical, muscle pathological, and pathogenic gene mutation characteristics of Andersen-Tawil Syndrome (ATS) and enhance the understanding of ATS among clinical practitioners.MethodsRetrospective analysis of clinical data and muscle
Jiaxuan Wang, Qianqian Qu, Xianzhao Zheng, Xiaoli Ma, Wenhao Cui, Zheng Lv, Cong Hu, Shiyao Li, Jiongbo Zhao, Haidong Lv   +9 more
doaj   +1 more source

Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cardiac arrhythmias are triggered by environmental stimuli that may modulate expression of cardiac ion channels. Underlying epigenetic regulation of cardiac electrophysiology remains incompletely understood.
Patrick Lugenbiel, Katharina Govorov, Ann-Kathrin Rahm, Teresa Wieder, Dominik Gramlich, Pascal Syren, Nadine Weiberg, Claudia Seyler, Hugo A. Katus, Dierk Thomas   +9 more
doaj   +1 more source

Identification of hypertension gene expression biomarkers based on the DeepGCFS algorithm.

PLoS ONE
Hypertension is a critical risk factor and cause of mortality in cardiovascular diseases, and it remains a global public health issue. Therefore, understanding its mechanisms is essential for treating and preventing hypertension.
Zongjin Li, Liqin Tian, Libing Bai, Zeyu Jia, Xiaoming Wu, Changxin Song   +5 more
doaj   +1 more source