Results 101 to 110 of about 5,101 (164)

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain

Cell Communication and Signaling
Bone cancer pain (BCP) represents a prevalent symptom among cancer patients with bone metastases, yet its underlying mechanisms remain elusive. This study investigated the transcriptional regulation mechanism of Kv7(KCNQ)/M potassium channels in DRG ...
Zi-Xian Zhang, Yue Tian, Song Li, Hong-Bo Jing, Jie Cai, Min Li, Guo-Gang Xing   +6 more
doaj   +1 more source

Early clinical prediction of neurodevelopmental outcome in KCNQ2-related disorders

Objective: In KCNQ2-related disorders (KCNQ2-RD), neurodevelopmental outcome remains variable despite established genotype-phenotype correlations.
Ingrid E. Scheffer, Sarah Weckhuysen, KCNQ2 Study Group, Pinar Gencpinar, Magdalena Krygier, Ludovica Montanucci, Elisabeth Van Boxstael, Irene Valenzuala Palafoll, Duccio Maria Cordelli, Safa Mete Dagdas, Steffen Syrbe, Didac Casas Alba, Carmen Fons, Laurence Chaton, Eugenia Roza, Tejasvi Niranjan, Annie Ting-Gee Chiu, Dennis Lal, Anna C. Jansen, Charissa Millevert, Mathieu Milh, An-Sofie Schoonjans, Gaetan Lesca, Christian Bosselmann, Marta Pietruszka, Laura Licchetta, Johannes R. Lemke, Megan Hairabedian, Tobias Brunger, Trine Bjorg Hammer   +29 more
core   +1 more source

Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2

, 2006
A mutation in the voltage-gated sodium-channel Scn2a results in moderate epilepsy in transgenic Scn2a(Q54) mice maintained on a C57BL/6J strain background.
Kearney, Jennifer A., Claes, L, Yang, Y, Beyer, B, Dejonghe, P, Beyer, Barbara, Frankel, Wayne N., De Jonghe, Peter, Bergren, S K, Yang, Yan, Bergren, Sarah K., Claes, Godelieve, Frankel, W N, Kearney, J A   +13 more
core   +1 more source

KCNQ2 Loss-of-Function variants disrupt neuronal maturation via early hyperexcitability followed by maladaptive network remodeling

: Loss-of-function (LOF) variants in the potassium channel subunit KCNQ2 cause a spectrum of neonatal epilepsies from self-limiting familial neonatal epilepsy (SeLFNE) to severe developmental and epileptic encephalopathy (DEE).
Lagae, L., Verstraelen, P., Dang, L.T., De Vos, W.H., Carleo, G., De Jonghe, P., De Vriendt, E., Miceli, F., Zonnekein, N., Vlaemynck, E., Kaji, M., Asselbergh, B., Ceulemans, B., Dirkx, N., Weckhuysen, S., Sommers, V., Carotenuto, L., Taglialatela, M.   +17 more
core   +1 more source

Ganoderic Acid A Ameliorates Pentylenetetrazol-Induced Epilepsy in Mice via Activating KCNQ2. [PDF]

CNS Neurosci Ther
Yao Y, Liu Z, Wang X, Bian C, Wang R, Zhang Y.   +5 more
europepmc   +1 more source

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2. [PDF]

Proc Natl Acad Sci U S A
Huey DJ, Guadarrama E, DeKeyser JM, Vanoye CG, Simmons CQ, Li Q, Stroup EK, Ji Z, George AL.   +8 more
europepmc   +1 more source

Identification of a Ste20-like kinase-dependent signaling network orchestrating cytoskeletal and synaptic development of cortical neurons. [PDF]

Cell Commun Signal
Quatraccioni A, Graham ME, Sylvester M, Hardt R, van Waardenberg AJ, Becker AJ, Schoch S.   +6 more
europepmc   +1 more source

KCNQ2 Gain-of-Function Mutation Presenting as Respiratory Dysfunction and Non-epileptic Myoclonus. [PDF]

Cureus
Abuzayda HA, Flayyih R, Abou Ali H, Hosain SA, Khan J.   +4 more
europepmc   +1 more source

Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of <i>KCNV2</i> Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy. [PDF]

Pharmaceuticals (Basel)
Pekkoc-Uyanik KC, Todurga-Seven ZG, Agay ER, Uzun H.   +3 more
europepmc   +1 more source

Clinical Features and Gene Mutation of Neonatal Seizures. [PDF]

J Clin Med
Guo L, Du A, An L, Ding G.
europepmc   +1 more source