Results 1 to 10 of about 8,606 (118)

Cardiocerebral channelopathy caused by KCND3 mutation in a child: A case report

Frontiers in Pediatrics, 2022
Early repolarization syndrome is rare in children. Mutation of genes encoding ion channels could display mixed electrophysiological phenotype of Kv4.3 including both cardiac phenotype (early repolarization syndrome, atrial fibrillation) and cerebral ...

exaly   +3 more sources

Channelopathy Genes in Pulmonary Arterial Hypertension

Biomolecules, 2022
Pulmonary arterial hypertension (PAH) is a rare, progressive vasculopathy with significant cardiopulmonary morbidity and mortality. The underlying pathogenetic mechanisms are heterogeneous and current therapies aim to decrease pulmonary vascular ...
Elfrida Malkin, Wendy Chung, Carrie Welch   +2 more
exaly   +3 more sources

Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model

Nature Communications, 2023
Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC) synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying regulatory mechanisms remain unknown.
Yu Tao, Yuan Zhang, Xiaohong Jin, Nan Hua, Hong Liu, Renfei Qi, Zitong Huang, Yufang Sun, Dongsheng Jiang, Terrance P. Snutch, Xinghong Jiang, Jin Tao   +11 more
doaj   +1 more source

Sex differences in global disability-adjusted life years due to ischemic stroke: findings from global burden of diseases study 2019

Scientific Reports, 2022
To investigate the sex differences in disability-adjusted life years (DALYs) due to ischemic stroke (IS) by year, location and age. We extracted sex-specific data on DALYs number, age-standardized DALYs rate (ASDR) and all-age DALYs rate of IS by year ...
Miaomiao Cao, Bolin Li, Jie Rong, Qian Li, Chaofeng Sun   +4 more
doaj   +1 more source

Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors

The Journal of Headache and Pain, 2023
Background Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown.
Yuan Zhang, Hua Wang, Yufang Sun, Zitong Huang, Yu Tao, Yiru Wang, Xinghong Jiang, Jin Tao   +7 more
doaj   +1 more source

Evaluation of subcutaneous implantable cardioverter-defibrillator performance in patients with ion channelopathies from the EFFORTLESS cohort and comparison with a meta-analysis of transvenous ICD outcomes

Heart Rhythm O2, 2020
Background: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative to conventional transvenous ICD (TV-ICD) therapy to reduce lead complications.
Pier D. Lambiase, MBChB, PhD, FHRS, Lars Eckardt, MD, Dominic A. Theuns, PhD, Timothy R. Betts, MD, Andreas L. Kyriacou, MBChB, FRCP, PhD, CCDS, Elizabeth Duffy, MS, Reinoud Knops, MD, PhD, CCDS   +6 more
doaj   +1 more source

1029 genomes of self-declared healthy individuals from India reveal prevalent and clinically relevant cardiac ion channelopathy variants

Human Genomics, 2022
Background The prevalence and genetic spectrum of cardiac channelopathies exhibit population-specific differences. We aimed to understand the spectrum of cardiac channelopathy-associated variations in India, which is characterised by a genetically ...
Anjali Bajaj, Vigneshwar Senthivel, Rahul Bhoyar, Abhinav Jain, Mohamed Imran, Mercy Rophina, Mohit Kumar Divakar, Bani Jolly, Ankit Verma, Anushree Mishra, Disha Sharma, Siddharthan Deepti, Gautam Sharma, Raghav Bansal, Rakesh Yadav, Vinod Scaria, Nitish Naik, Sridhar Sivasubbu   +17 more
doaj   +1 more source

Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Cell Communication and Signaling, 2019
Background Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.
Shumin Yu, Yuan Zhang, Xianyang Zhao, Zhigang Chang, Yuan Wei, Yufang Sun, Dongsheng Jiang, Xinghong Jiang, Jin Tao   +8 more
doaj   +1 more source

Electrical stimulation of the superior sagittal sinus suppresses A-type K+ currents and increases P/Q- and T-type Ca2+ currents in rat trigeminal ganglion neurons

The Journal of Headache and Pain, 2019
Background Migraine is a debilitating neurological disorder involving abnormal trigeminovascular activation and sensitization. However, the underlying cellular and molecular mechanisms remain unclear.
Junping Cao, Yuan Zhang, Lei Wu, Lidong Shan, Yufang Sun, Xinghong Jiang, Jin Tao   +6 more
doaj   +1 more source

Hypoxia induces voltage-gated K+ (Kv) channel expression in pulmonary arterial smooth muscle cells through hypoxia-inducible factor-1 (HIF-1)

Biomolecules & Biomedicine, 2012
Hypoxia-inducible factor-1 (HIF-1) regulates the expression of hypoxia-inducible genes by binding erythropoietin (EPO) enhancer fragments. Of these genes, HIF-1 upregulates voltage-gated K+1.2 channels (Kv1.2) in rat PC12 cells.
Qian Dong, Ning Zhao, Cheng-kun Xia, Li-li Du, Xiao-xing Fu, Yi-mei Du   +5 more
doaj   +1 more source