Results 31 to 40 of about 9,985 (188)
Frontiers in Cardiovascular Medicine, 2021 It is well-known that gender is an independent risk factor for some types of cardiac arrhythmias. For example, males have a greater prevalence of atrial fibrillation and the Brugada Syndrome.
Sarah Costa +7 more
doaj +1 more source
, 2023 The KCNA1 gene encodes Kv1.1 voltage-gated potassium channel α subunits, which are crucial for maintaining healthy neuronal firing and preventing hyperexcitability.
Edward Glasscock, Kelsey Paulhus
core +1 more source
Clinical Case Reports, 2020 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a channelopathy which can lead to fatal ventricular arrhythmias. The diagnosis can be challenging due to a wide variety of clinical presentations.
Collin C. Kramer +3 more
doaj +1 more source
Roles for Countercharge in the Voltage Sensor Domain of Ion Channels
Frontiers in Pharmacology, 2020 Voltage-gated ion channels share a common structure typified by peripheral, voltage sensor domains. Their S4 segments respond to alteration in membrane potential with translocation coupled to ion permeation through a central pore domain.
James R. Groome +2 more
doaj +1 more source
Анналы клинической и экспериментальной неврологии, 2017 Despite the fact that small fiber neuropathy (SFN) has already been studied for 30 years, it remains one of the most mysterious diseases that are extremely difficult to diagnose and cure.
Natalya A. Suponeva +6 more
doaj +1 more source
, 2022 Additional file 8: Allele frequencies of pathogenic and likely pathogenic cardiac channelopathy variants across different genomic ...
Anjali Bajaj (13206910) +17 more
core +1 more source
INWARD RECTIFIERS AND THEIR REGULATION BY ENDOGENOUS POLYAMINES
Frontiers in Physiology, 2014 Inwardly-rectifying potassium (Kir) channels contribute to maintenance of the resting membrane potential and regulation of electrical excitation in many cell types.
Victoria A Baronas +1 more
doaj +1 more source
Genetic Variants in <i>SDC3</i>, <i>KCNA2</i>, <i>KCNK1</i>, <i>KCNK16,</i> and <i>Heat Shock Transcription Factor-1</i> Genes: An Exploratory Analysis Supporting the Piezo2 Channelopathy Hypothesis in Amyotrophic Lateral Sclerosis Onset. [PDF]
Int J Mol SciAmyotrophic lateral sclerosis (ALS) is a multisystem progressive neurodegenerative disease. A recent theory of ALS onsetting pathogenesis proposed that the initiating primary damage is an acquired irreversible intrafusal proprioceptive terminal PIEZO2 ...
Sonkodi B +5 more
europepmc +2 more sources
Frontiers in Cell and Developmental Biology, 2019 BackgroundAmong rare channelopathies BrS patients are at high risk of sudden cardiac death (SCD). SCN5A mutations are found in a quarter of patients. Other rare gene mutations including SCN1B have been implicated to BrS.
Ibrahim El-Battrawy +38 more
doaj +1 more source
Sepsis induced channelopathy in skeletal muscles is associated with expression of non selective channels [PDF]
, 2018 Skeletal muscles (similar to 50% of the body weight) are affected during acute and late sepsis and represent one sepsis associate organ dysfunction. Cell membrane changes have been proposed to result from a channelopathy of yet unknown cause associated ...
Rosalba Escamilla +20 more
core +1 more source