Results 11 to 20 of about 8,166 (199)

Channelopathies [PDF]

Korean Journal of Pediatrics, 2014
Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all cells and many cellular organelles. These include diseases of the nervous system (e.g., generalized epilepsy with febrile seizures plus, familial hemiplegic migraine, episodic ataxia, and hyperkalemic and hypokalemic ...
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Calcium channelopathies [PDF]

Kidney International, 2000
Calcium is an important intracellular signaling molecule, and altered calcium channel function can cause widespread cellular changes. Genetic mutations in calcium channels that cause what appear to be trivial alterations of calcium currents in vitro can result in serious diseases in muscles and the nervous system.
Lorenzon, Nancy M., Beam, Kurt G.
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Neurological channelopathies [PDF]

Postgraduate Medical Journal, 2005
Abstract Ion channels are membrane-bound proteins that perform key functions in virtually all human cells. Such channels are critically important for the normal function of the excitable tissues of the nervous system, such as muscle and brain.
T D, Graves, M G, Hanna
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Electrical stimulation of the superior sagittal sinus suppresses A-type K+ currents and increases P/Q- and T-type Ca2+ currents in rat trigeminal ganglion neurons

The Journal of Headache and Pain, 2019
Background Migraine is a debilitating neurological disorder involving abnormal trigeminovascular activation and sensitization. However, the underlying cellular and molecular mechanisms remain unclear.
Junping Cao, Yuan Zhang, Lei Wu, Lidong Shan, Yufang Sun, Xinghong Jiang, Jin Tao   +6 more
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Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Cell Communication and Signaling, 2019
Background Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.
Shumin Yu, Yuan Zhang, Xianyang Zhao, Zhigang Chang, Yuan Wei, Yufang Sun, Dongsheng Jiang, Xinghong Jiang, Jin Tao   +8 more
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Hypoxia induces voltage-gated K+ (Kv) channel expression in pulmonary arterial smooth muscle cells through hypoxia-inducible factor-1 (HIF-1)

Biomolecules & Biomedicine, 2012
Hypoxia-inducible factor-1 (HIF-1) regulates the expression of hypoxia-inducible genes by binding erythropoietin (EPO) enhancer fragments. Of these genes, HIF-1 upregulates voltage-gated K+1.2 channels (Kv1.2) in rat PC12 cells.
Qian Dong, Ning Zhao, Cheng-kun Xia, Li-li Du, Xiao-xing Fu, Yi-mei Du   +5 more
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STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases

Frontiers in Physiology, 2020
Store-operated Ca2+ entry (SOCE) is a ubiquitous and essential mechanism regulating Ca2+ homeostasis in all tissues, and controls a wide range of cellular functions including keratinocyte differentiation, osteoblastogenesis and osteoclastogenesis, T cell
Roberto Silva-Rojas, Jocelyn Laporte, Johann Böhm   +2 more
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The Function of Ion Channels and Membrane Potential in Red Blood Cells: Toward a Systematic Analysis of the Erythroid Channelome

Frontiers in Physiology, 2022
Erythrocytes represent at least 60% of all cells in the human body. During circulation, they experience a huge variety of physical and chemical stimulations, such as pressure, shear stress, hormones or osmolarity changes.
Marieke von Lindern, Marieke von Lindern, Stéphane Egée, Stéphane Egée, Paola Bianchi, Lars Kaestner, Lars Kaestner   +6 more
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A review of potassium channels in bipolar disorder

Frontiers in Genetics, 2013
Although bipolar disorder (BP) is one of the most heritable psychiatric conditions, susceptibility genes for the disorder have yet to be conclusively identified.
Jennifer Toolan Judy, Peter eZandi, Peter eZandi   +2 more
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A de novo GRIN1 Variant Associated With Myoclonus and Developmental Delay: From Molecular Mechanism to Rescue Pharmacology

Frontiers in Genetics, 2021
N-Methyl-D-aspartate receptors (NMDARs) are highly expressed in brain and play important roles in neurodevelopment and various neuropathologic conditions.
Jin Zhang, Weiting Tang, Nidhi K. Bhatia, Yuchen Xu, Yuchen Xu, Nabina Paudyal, Ding Liu, Sukhan Kim, Sukhan Kim, Rui Song, Rui Song, Wenshu XiangWei, Gil Shaulsky, Scott J. Myers, Scott J. Myers, William Dobyns, Vasanthi Jayaraman, Stephen F. Traynelis, Stephen F. Traynelis, Hongjie Yuan, Hongjie Yuan, Xiuhua Bozarth, Xiuhua Bozarth   +22 more
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