Results 41 to 50 of about 5,101 (164)
Expression of wild-type KCNQ2 but not KCNQ2-A343D or KCNQ2-R353G decreases neuronal excitability.
, 2014 (A) Hypothesis by which exogeneously expressed KCNQ2 subunits affect neuronal excitability. At an early stage of hippocampal culture, the level of endogenous KCNQ2/KCNQ3 channels is low [42].
John P. Cavaretta (606562) +5 more
core +1 more source
Epilepsy-associated KCNQ2 channels regulate multiple intrinsic properties of layer 2/3 pyramidal neurons [PDF]
, 2017 © 2017 the authors. KCNQ2 potassium channels are critical for normal brain function, as both loss-of-function and gain-of-function KCNQ2 variants can lead to various forms of neonatal epilepsy.
Tzingounis, AV +4 more
core +2 more sources
Advanced Science, EarlyView.Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu +7 more
wiley +1 more source
Investigations on subunit-specific assembly and structure-function studies of the voltage sensor in KCNQ potassium channels [PDF]
, 2007 A detailed understanding of how potassium channels function is crucial e. g. for the development of drugs, which could lead to novel therapeutic concepts for diseases ranging from diabetes to cardiac abnormalities.
Athanasiadu, Despina, Athanasiadu, D.
core
Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]
, 1999 The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC +7 more
core
Orofacial neuropathic pain induced by oxaliplatin
Molecular Pain, 2017 Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic pain are not fully understood.
Jennifer Ling +4 more
doaj +1 more source
Clinical characteristics and genotype-phenotype correlation analysis of 43 cases of neonatal hereditary epilepsy [PDF]
Linchuang erke zazhiObjective To analyze the clinical and genetic variation characteristics of hereditary epilepsy in neonates and explore the correlation between the characteristics of genetic variations and clinical manifestations.
HUO Xiangzi, FENG Lijuan, MENG Lingzhi, ZHANG Yudong, SUN Yuli, MA Li, CAO Yanyan, XIA Yaofang
doaj +1 more source
Epileptic Disorders, EarlyView.Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype–phenotype ...
Burcu Yaman +7 more
wiley +1 more source
The spectrum of KCNQ2- And KCNQ3-related epilepsy
, 2023 KCNQ genes encode for a family of six transmembrane domains, single pore-loop, and K+ channel α-subunits that have a wide range of physiological correlates.
Comella M. +7 more
core +1 more source
Epilepsia OpenObjective To summarize the clinical features and genetic mutation characteristics of Chinese children with KCNQ2‐related epilepsy. Methods A cohort of children with genetically caused epilepsy was evaluated at Linyi People's Hospital from January 2017 to
Xixi Yu +7 more
doaj +1 more source