Results 1 to 10 of about 8,066 (137)

Integration of Trypanosoma cruzi kDNA minicircle sequence in the host genome may be associated with autoimmune serum factors in Chagas disease patients [PDF]

Memorias do Instituto Oswaldo Cruz, 1999
Integration of kDNA sequences within the genome of the host cell shown by PCR amplification with primers to the conserved Trypanosoma cruzi kDNA minicircle sequence was confirmed by Southern hybridization with specific probes.
Augusto Simões-Barbosa, Ana Maria Barros, Nadjar Nitz, Enrique R Argañaraz, Antonio RL Teixeira   +4 more
doaj   +5 more sources

Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes. [PDF]

PLoS Pathogens
The kinetoplast incorporates the large mitochondrial genome present in the eponymous Kinetoplastida. Trypanosoma brucei is an African trypanosome that can lose kinetoplast DNA (kDNA), however, when the nuclear-encoded gamma subunit of the mitochondrial ...
Melanie Ridgway, Douglas O Escrivani, Markéta Novotná, Amy Wood, Michele Tinti, Achim Schnaufer, David Horn   +6 more
doaj   +2 more sources

Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex. [PDF]

PLoS Pathogens
The Tripartite Attachment Complex (TAC) is essential for mitochondrial DNA (kDNA) segregation in Trypanosoma brucei, providing a physical link between the flagellar basal body and the mitochondrial genome.
Clirim Jetishi, Salome Aeschlimann, Bernd Schimanski, Sandro Käser, Rachel Mullner, Silke Oeljeklaus, Bungo Akiyoshi, Bettina Warscheid, Falk Butter, André Schneider, Torsten Ochsenreiter   +10 more
doaj   +2 more sources

From mitochondrial DNA arrangement to repair: a kinetoplast-associated protein with different roles in two trypanosomatid species [PDF]

Parasites & Vectors
Background One of the most intriguing and unusual features of trypanosomatids is their mitochondrial DNA, known as kinetoplast DNA (kDNA), which is organized into a network of concatenated circles.
Camila Silva Gonçalves, Carolina Moura Costa Catta-Preta, Bruno Marçal Repolês, Wesley Roger Rodrigues Ferreira, Flavia Souza Morini, Jeremy C. Mottram, Danielle Pereira Cavalcanti, Wanderley de Souza, Stenio Perdigão Fragoso, Carlos Renato Machado, Maria Cristina M. Motta   +10 more
doaj   +2 more sources

Biparental Inheritance and Instability of kDNA in Experimental Hybrids of Trypanosoma cruzi: A Proposal for a Mechanism [PDF]

Biology
The mitochondrial DNA of trypanosomatid parasites consists of thousands of catenated minicircles and dozens of maxicircles that form a complex network structure, the kinetoplast (kDNA).
Nicolás Tomasini, Tatiana Ponce, Fanny Rusman, Soledad Hodi, Noelia Floridia-Yapur, Anahí Guadalupe Díaz, Juan José Aguirre, Gabriel Machado Matos, Björn Andersson, Michael D. Lewis, Patricio Diosque   +10 more
doaj   +2 more sources

Analytical and clinical performance of in-house and commercial real-time PCR assays for diagnosing L. infantum visceral leishmaniasis: a study from a hub center in Northern Italy [PDF]

Journal of Clinical Microbiology
Molecular methods are increasingly used to diagnose visceral leishmaniasis (VL), a life-threatening disease caused by Leishmania infantum in the Mediterranean basin.
Tommaso Gritti, Beatrice Mola, Lisa Argnani, Bianca Granozzi, Michele Bacchiega, Fraia Melchionda, Arianna Dondi, Giacomo Nigrisoli, Silvia Castaldini, Luca Prodi, Tiziana Lazzarotto, Matt Denwood, Stefania Varani, Margherita Ortalli   +13 more
doaj   +2 more sources

An independently tunable dual control system for RNAi complementation in Trypanosoma brucei. [PDF]

PLoS ONE
Trypanosoma brucei is a tractable protist parasite for which many genetic tools have been developed to study novel biology. A striking feature of T. brucei is the catenated mitochondrial DNA network called the kinetoplast DNA (kDNA) that is essential for
Raveen Armstrong, Matt J Romprey, Henry M Raughley, Stephanie B Delzell, Matthew P Frost, James Chambers, Grace G Garman, David Anaguano, Michele M Klingbeil   +8 more
doaj   +2 more sources

Sensitive and specific detection of Trypanosoma cruzi DNA in clinical specimens using a multi-target real-time PCR approach [PDF]

, 2012
Background: The laboratory diagnosis of Chagas disease is challenging because the usefulness of different diagnostic tests will depend on the stage of the disease.
Aznar, Christine, da Silva, Alexandre J., Qvarnstrom, Yvonne, Schijman, Alejandro Gabriel, Steurer, Francis, Veron, Vincent   +5 more
core   +13 more sources

kDNA and Molecular Typing of Leishmania spp. of Cutaneous Leishmaniasis Patients in Sistan and Baluchestan Province with Low Amount of Parasite [PDF]

Journal of Kerman University of Medical Sciences, 2019
Background: Cutaneous Leishmaniasis, is endemically observed in different parts of Iran in two forms of anthroponotic and zoonotic. The identification of both species and the type of disease are beneficial for treatment and prevention.
Hadi Mirahmadi, Ahmad Mehravaran, Nasrin Rezaee, Saber Gholizadeh, Saber Raeghi, Elham-Sadat Roointan   +5 more
doaj   +1 more source

Direct monitoring of the stepwise condensation of kinetoplast DNA networks

Scientific Reports, 2021
Condensation and remodeling of nuclear genomes play an essential role in the regulation of gene expression and replication. Yet, our understanding of these processes and their regulatory role in other DNA-containing organelles, has been limited.
Nurit Yaffe, Dvir Rotem, Awakash Soni, Danny Porath, Joseph Shlomai   +4 more
doaj   +1 more source