Results 11 to 20 of about 8,135 (198)

EdU labeling of Trypanosome Cells and Their Kinetoplast DNA (kDNA)

Bio-Protocol, 2013
Trypanosome mitochondrial genome, known as Kinetoplast DNA (kDNA), is a massive network of interlocked DNA rings. The studies of kDNA replication and architecture are of major significance since kDNA is a valid drug target.
Jianyang Wang
doaj   +2 more sources

Mexican Trypanosoma cruzi stocks: analysis of minicircle kDNA homologies by cross-hybridization [PDF]

Memorias do Instituto Oswaldo Cruz, 2000
Homologies of minicircle kDNA of 27 Mexican stocks were studied by cross-hybridization with four kDNA probes derived from three reference stocks belonging to groups Trypanosoma cruzi I (SO34 cl4 and Silvio) and T.
Marie-France Bosseno, Bertha Espinoza, Beatriz Sánchez, Simone Frédérique Brenière   +3 more
doaj   +5 more sources

APPLICABILITY OF kDNA-PCR FOR ROUTINE DIAGNOSIS OF AMERICAN TEGUMENTARY LEISHMANIASIS IN A TERTIARY REFERENCE HOSPITAL [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2013
SUMMARY This study evaluated the applicability of kDNA-PCR as a prospective routine diagnosis method for American tegumentary leishmaniasis (ATL) in patients from the Instituto de Infectologia Emílio Ribas (IIER), a reference center for infectious ...
Marcela M. Satow, Edite H. Yamashiro-Kanashiro, Mussya C. Rocha, Luiza K. Oyafuso, Rita C. Soler, Paulo C. Cotrim, Jose Angelo L. Lindoso   +6 more
doaj   +4 more sources

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome. [PDF]

FEBS J
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
von Känel C, Aeschlimann S, Husová M, Oeljeklaus S, Stettler P, Schnaufer A, Warscheid B, Zíková A, Schneider A.   +8 more
europepmc   +3 more sources

USEFULNESS OF kDNA PCR IN THE DIAGNOSIS OF VISCERAL LEISHMANIASIS REACTIVATION IN CO-INFECTED PATIENTS [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2013
SUMMARY It is important to develop new methods for diagnosing relapses in the co-infection of visceral leishmaniasis (VL) and HIV to enable earlier detection using less invasive methods. We report a case of a co-infected patient who had relapses after VL
Antonio Carlos Nicodemo, Valdir Sabbaga Amato, Felipe Francisco Tuon, Regina Maia de Souza, Thelma Suely Okay, Lucia Maria Almeida Braz   +5 more
doaj   +4 more sources

Subspecific kDNA probes for major clones of Trypanosoma cruzi [PDF]

Acta Tropica, 1990
clones,' a limited number are repeatedly sampled over large geographical areas and long periods of time. These widespread clones have been named Lmajor clones': their medical and epidemiological characteristics deserve to be investigated with utmost priority (Tibayrenc and Breniere, 1988).
Brenière, Simone Frédérique, Cuny, G., Tibayrenc, Michel, Veas, Francisco   +3 more
core   +4 more sources

Assessment of Leishmania exposure in blood donors from a non-endemic urban area: A study in São Paulo. [PDF]

Vox Sang
Abstract Background and Objectives According to the World Health Organization, more than 1 billion people are at risk of leishmaniasis in over 89 countries. Environmental changes such as deforestation, urban expansion and climate change facilitate the spread of sand fly vectors and reservoirs, increasing disease transmission.
de Lima IS, Ferreira SC, Nishiya AS, Kesper N, Ferreira JE, de Castro Gomes CM, Derriga J, Dantas KC, Polato SPG, Salles NA, Lindoso JAL, Fanciani T, de Almeida-Neto C, Rocha V, Mendrone A.   +14 more
europepmc   +2 more sources

Native rodent species are unlikely sources of infection for Leishmania (Viannia) braziliensis along the Transoceanic Highway in Madre de Dios, Peru. [PDF]

, 2014
An estimated 2.3 million disability-adjusted life years are lost globally from leishmaniasis. In Peru's Amazon region, the department of Madre de Dios (MDD) rises above the rest of the country in terms of the annual incidence rates of human leishmaniasis.
Conrad, Patricia A, De Los Santos, Maxy, Ghersi, Bruno M, Lescano, Andres G, Mazet, Jonna AK, Montgomery, Joel M, Razuri, Hugo, Shender, Lisa A   +7 more
core   +10 more sources

Importance of Angomonas deanei KAP4 for kDNA arrangement, cell division and maintenance of the host-bacterium relationship

Scientific Reports, 2021
Angomonas deanei coevolves in a mutualistic relationship with a symbiotic bacterium that divides in synchronicity with other host cell structures.
Camila Silva Gonçalves, Carolina Moura Costa Catta-Preta, Bruno Repolês, Jeremy C. Mottram, Wanderley De Souza, Carlos Renato Machado, Maria Cristina M. Motta   +6 more
doaj   +1 more source

Evaluation of conventional and four real-time PCR methods for the detection of Leishmania on field-collected samples in Ethiopia.

PLoS Neglected Tropical Diseases, 2021
In most low-resource settings, microscopy still is the standard method for diagnosis of cutaneous leishmaniasis, despite its limited sensitivity. In Ethiopia, the more sensitive molecular methods are not yet routinely used.
Behailu Merdekios, Myrthe Pareyn, Dagimawie Tadesse, Nigatu Eligo, Mekibib Kassa, Bart K M Jacobs, Herwig Leirs, Jean-Pierre Van Geertruyden, Johan van Griensven, Guy Caljon, Lieselotte Cnops   +10 more
doaj   +1 more source