Minicircle kDNA microheterogeneity in Endotrypanum indicate diversity within this genus [PDF]
Memórias do Instituto Oswaldo Cruz, 2000 A comparison of kDNA restriction-endonuclease fragment patterns from strains representing selected Endotrypanum zymodemes was done by schizodeme analysis. As the degree of heterogeneity within mini-circles varied among species or strains of Endotrypanum, the fingerprint obtained with each of the restriction enzymes was unique for each of these ...
Pereira, Antonia Maria Ramos Franco +3 more
openaire +4 more sources
Inhibition of autoimmune Chagas-like heart disease by bone marrow transplantation. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND:Infection with the protozoan Trypanosoma cruzi manifests in mammals as Chagas heart disease. The treatment available for chagasic cardiomyopathy is unsatisfactory.
Maria C Guimaro +13 more
doaj +1 more source
Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]
, 2014 It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer +32 more
core +1 more source
The Trypanosoma cruzi satellite DNA OligoC-TesT and Trypanosoma cruzi kinetoplast DNA OligoC-TesT for diagnosis of Chagas disease: a multi-cohort comparative evaluation study. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND: The Trypanosoma cruzi satellite DNA (satDNA) OligoC-TesT is a standardised PCR format for diagnosis of Chagas disease. The sensitivity of the test is lower for discrete typing unit (DTU) TcI than for TcII-VI and the test has not been ...
Koen De Winne +17 more
doaj +1 more source
A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei.
PLoS Pathogens, 2017 The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle.
Priscila Peña-Diaz +4 more
doaj +1 more source
Development of a LAMP assay for detection of Leishmania infantum infection in dogs using conjunctival swab samples [PDF]
, 2015 Background: Leishmania infantum infections in dogs play a crucial role in the transmission of pathogens causing visceral leishmaniasis to humans in the Gansu province, northwest China. To be able to control zoonotic transmission of the parasite to humans,
A Moshfe +48 more
core +1 more source
Identification of a bacterial-like HslVU protease in the mitochondria of Trypanosoma brucei and its role in mitochondrial DNA replication. [PDF]
PLoS Pathogens, 2008 ATP-dependent protease complexes are present in all living organisms, including the 26S proteasome in eukaryotes, Archaea, and Actinomycetales, and the HslVU protease in eubacteria.
Ziyin Li +4 more
doaj +1 more source
On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei [PDF]
, 2014 Background: Although technical advances in genomics and proteomics research have yielded a better understanding of the coding capacity of a genome, one major challenge remaining is the identification of all expressed proteins, especially those less than ...
Butter, F. +5 more
core +2 more sources
Properties of Topological Networks of Flexible Polygonal Chains
Computational and Mathematical Biophysics, 2014 Trypanosomatida parasites, such as Trypanosoma and Leishmania, are the cause of deadly diseases in many third world countries. The three dimensional structure of their mitochondrial DNA, known as kinetoplast DNA (kDNA), is unique since it is organized ...
Arsuaga J. +3 more
doaj +1 more source
PLoS Pathogens, 2022 The protist parasite Trypanosoma brucei has a single mitochondrion with a single unit genome termed kinetoplast DNA (kDNA). Faithfull segregation of replicated kDNA is ensured by a complicated structure termed tripartite attachment complex (TAC). The TAC
Bernd Schimanski +8 more
doaj +1 more source