Effects of TcFLA-1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures. [PDF]
Cell Biol IntABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Souza-Melo N, de Souza GH, de Souza W.
europepmc +2 more sources
The killing of African trypanosomes by ethidium bromide.
PLoS Pathogens, 2010 Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial.
Arnab Roy Chowdhury +10 more
doaj +1 more source
Genetic, serological and biochemical characterization of Leishmania tropica from foci in northern Palestine and discovery of zymodeme MON-307 [PDF]
, 2012 Background Many cases of cutaneous leishmaniasis (CL) have been recorded in the Jenin District based on their clinical appearance. Here, their parasites have been characterized in depth.
A Al-Jawabreh +48 more
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BMC Microbiology, 2009 Background The kinetoplast DNA (kDNA) of trypanosomatids consists of an unusual arrangement of circular molecules catenated into a single network. The diameter of the isolated kDNA network is similar to that of the entire cell.
Cavalcanti Danielle +7 more
doaj +1 more source
Trypanosoma evansi: Genetic variability detected using amplified restriction fragment length polymorphism (AFLP) and random amplified polymorphic DNA (RAPD) analysis of Kenyan isolates [PDF]
, 2006 We compared two methods to generate polymorphic markers to investigate the population genetics of Trypanosoma evansi; random amplified polymorphic DNA (RAPD) and amplified restriction fragment length polymorphism (AFLP) analyses.
Agbo +39 more
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An oligonucleotide probe derived from kDNA minirepeats is specific for Leishmania (Viannia) [PDF]
Memórias do Instituto Oswaldo Cruz, 1996 Sequence analysis of Leishmania (Viannia) kDNA minicircles and analysis of multiple sequence alignments of the conserved region (minirepeats) of five distinct minicircles from L. (V.) braziliensis species with corresponding sequences derived from other dermotropic leishmanias indicated the presence of a sub-genus specific sequence.
Octávio Fernandes +5 more
openaire +4 more sources
Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3 [PDF]
, 2010 double Holliday junction (dHJ) is a central intermediate of homologous recombination that can be processed to yield crossover or non-crossover recombination products. To preserve genomic integrity, cells possess mechanisms to avoid crossing over. We show
C Gaillard +37 more
core +2 more sources
Multiplex PCR as a tool for the diagnosis of Leishmania spp. kDNA and the gapdh housekeeping gene of mammal hosts. [PDF]
PLoS ONE, 2017 BACKGROUND:The PCR assays usually employed for Leishmania diagnosis does not simultaneously detect a constitutive gene that would certify the viability of the DNA sample.
Renata de Cássia-Pires +3 more
doaj +1 more source
Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]
, 2017 A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie +13 more
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Ars Veterinaria, 2013 A leishmaniose visceral é uma zoonose de extrema relevância quanto aos aspectos de saúde pública. É causada por protozoários tripanossomatídeos do gênero Leishmania e tem o cão doméstico como o principal reservatório no meio urbano. As enzootias costumam preceder a ocorrência em humanos, sendo este um importante parâmetro na predição de ...
C. J. COIRO, R. C. SILVA, H. LANGONI
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