Orientation of DNA Minicircles Balances Density and Topological Complexity in Kinetoplast DNA. [PDF]
PLoS ONE, 2015 Kinetoplast DNA (kDNA), a unique mitochondrial structure common to trypanosomatid parasites, contains thousands of DNA minicircles that are densely packed and can be topologically linked into a chain mail-like network.
Yuanan Diao +3 more
doaj +1 more source
Phylogenetic analysis of kinetoplast DNA: kDNA of Leishmania tropica in Thi-Qar province, Iraq [PDF]
Comparative Immunology, Microbiology and Infectious Diseases, 2020 AbstractIntroductionCutaneous leishmaniasis (CL) is one of wobbling endemic disease in Iraq, that cause intracellular obligate protistan parasite returned to the genusLeishmania. This study is aimed to identify epidemiology of CL, detect the prevalence ofLeishmania tropicaand find the phylogenetic relationship.MethodologyThe current study was conducted
Mohammed Hassan Flaih +2 more
openaire +2 more sources
TAC102 Is a Novel Component of the Mitochondrial Genome Segregation Machinery in Trypanosomes.
PLoS Pathogens, 2016 Trypanosomes show an intriguing organization of their mitochondrial DNA into a catenated network, the kinetoplast DNA (kDNA). While more than 30 proteins involved in kDNA replication have been described, only few components of kDNA segregation machinery ...
Roman Trikin +8 more
doaj +1 more source
KDNA genetic signatures obtained by LSSP-PCR analysis of Leishmania (Leishmania) infantum isolated from the new and the old world. [PDF]
PLoS ONE, 2012 BackgroundVisceral Leishmaniasis (VL) caused by species from the Leishmania donovani complex is the most severe form of the disease, lethal if untreated. VL caused by Leishmania infantum is a zoonosis with an increasing number of human cases and millions
Janaína Sousa Campos Alvarenga +6 more
doaj +1 more source
Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas disease in a patient with AIDS [PDF]
, 2005 Trypanosoma cruzi DNA was amplified from an intracranial biopsy and peripheral blood of an HIV patient with encephalitis; this episode was indicative of AIDS and congenital Chagas disease.
Altcheh, Jaime Marcelo +15 more
core +1 more source
Microorganisms, 2022 We report the study of sandfly Leishmania infection in an area of low incidence of visceral leishmaniasis in Tunisia. Sandflies were collected monthly using CDC light-traps set in houses and animal shelters during May–November 2016 and 2017.
Marwa Weslati +5 more
doaj +1 more source
PLoS ONE, 2021 The single mitochondrial nucleoid (kinetoplast) of Trypanosoma brucei is found proximal to a basal body (mature (mBB)/probasal body (pBB) pair). Kinetoplast inheritance requires synthesis of, and scission of kinetoplast DNA (kDNA) generating two ...
Catherine Sullenberger +4 more
doaj +1 more source
DIVERSet JAG compounds inhibit topoisomerase II and are effective against adult and pediatric high-grade gliomas [PDF]
, 2019 High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients.
Ajaz +51 more
core +2 more sources
Expanded repertoire of kinetoplast associated proteins and unique mitochondrial DNA arrangement of symbiont-bearing trypanosomatids. [PDF]
PLoS ONE, 2017 In trypanosomatids, the kinetoplast is the portion of the single mitochondrion that is connected to the basal body and contains the kDNA, a network composed by circular and interlocked DNA. The kDNA packing is conducted by Kinetoplast Associated Proteins
Silvana Sant Anna de Souza +8 more
doaj +1 more source
Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis [PDF]
, 2015 Background The contribution of individuals with subclinical infection to the transmission and endemicity of cutaneous leishmaniasis (CL) is unknown. Immunological evidence of exposure to Leishmania in residents of endemic areas has been the basis for ...
Adams, Emily
core +1 more source