Results 71 to 80 of about 8,135 (198)

A simple procedure for detecting proteins that bind preferentially to kDNA networks [PDF]

FEMS Microbiology Letters, 1989
A procedure is described in which a fractionated protein extract from the trypanosome Crithidia fasciculata was incubated either with deproteinized C. fasciculata kDNA networks or nuclear DNA. At least three proteins in the range of 45-65 kDa had a specific affinity for the networks.
openaire   +2 more sources

Smartphone-readable RPA-LFA for the high-sensitivity detection of Leishmania kDNA using nanophosphor reporters

PLOS Neglected Tropical Diseases, 2023
Early diagnosis of infectious diseases improves outcomes by enabling earlier delivery of effective treatment, and helps prevent further transmission by undiagnosed persons. We demonstrated a proof-of-concept assay combining isothermal amplification and lateral flow assay (LFA) for early diagnosis of cutaneous leishmaniasis, a vector-borne infectious ...
Adheesha N. Danthanarayana, Suman Nandy, Katerina Kourentzi, Binh Vu, Thomas R. Shelite, Bruno L. Travi, Jakoah Brgoch, Richard C. Willson   +7 more
openaire   +3 more sources

Trypanosoma brucei Polo‐like kinase is essential for basal body duplication, kDNA segregation and cytokinesis [PDF]

Molecular Microbiology, 2007
SummaryPolo‐like kinases (PLKs) are conserved eukaryotic cell cycle regulators, which play multiple roles, particularly during mitosis. The function of Trypanosoma brucei PLK was investigated in procyclic and bloodstream‐form parasites. In procyclic trypanosomes, RNA interference (RNAi) of PLK, or overexpression of TY1‐epitope‐tagged PLK (PLKty), but ...
Hammarton, Tansy C., Kramer, Susanne, Tetley, Laurence, Boshart, Michael, Mottram, Jeremy C.   +4 more
openaire   +3 more sources

Leishmaniasis in Morocco: Epidemiology, Transmission Dynamics, and the Potential of Artificial Intelligence for Disease Management

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Leishmaniases are neglected tropical diseases caused by Leishmania parasites and transmitted by infected phlebotomine sand flies, and they remain a major public health challenge in Morocco. The burden is dominated by cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL), mainly associated with Leishmania major, Leishmania tropica, and L ...
Chaymaa Harkat, Denis Sereno, Abdelmohcine Aimrane, Moulay Abdelmonaim Hidan, Mohamed Yamani, Kholoud Kahime, J.M.P. Barçante   +6 more
wiley   +1 more source

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics [PDF]

, 2012
Trypanosoma brucei survives in mammals through antigenic variation, which is driven by RAD51-directed homologous recombination of Variant Surface Glycoproteins (VSG) genes, most of which reside in a subtelomeric repository of >1000 silent genes. A key
Alsford, Anna Trenaman, Ayoub, Becker, Bennett, Bork, Bringaud, Brough, Callejas, Carlos R. Machado, Carreira, Carreira, Chung, Claire Hartley, Danielle G. Passos-Silva, Daniels, Davies, Davies, Dobson, Dray, Dumont, Esashi, Esashi, Futamura, Genois, Giloni, Glover, Hartley, Hashimoto, Heyer, Jackson, Jeyasekharan, Kim, Kim, Ko, Kojic, Kojic, Kojic, Lee, Lisby, Lo, Lord, Marcello, Marko Prorocic, Marmorstein, McCulloch, McKean, McKean, Melville, Mizuta, Moniek van den Hoek, Morrison, Munday, Oyola, Park, Petalcorin, Proudfoot, Raz, Regis-da-Silva, Renzette, Richard McCulloch, Robinson, Saeki, Schlacher, Shivji, Tarsounas, Tarsounas, Vink, Volodymyr Nechyporuk-Zloy, Yu, Zeiner, Zhou   +71 more
core   +1 more source

Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross‐Pathogen Diagnostic Universality

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Modular nanosensing platforms utilize nanomaterials and functionalized interfaces to amplify trace different pathogens (like tuberculosis) antigen capture, suppress matrix interference, and enable multiplex detection. Their portability and cost‐effectiveness support rapid screening in resource‐limited settings and real‐time monitoring, advancing high ...
Mei Li, Yuxin Luo, Wenqiang Li, Yiqing Wang, Yunze Tai, Zhiping Deng, Yao Luo   +6 more
wiley   +1 more source

Prevention and control of Chagas Disease : an overview [PDF]

, 2018
Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities ...
Almeida, A. B., Anunciação, C. E., Araujo, P. F., Gomes, C., Lacerda, E. Silveira, Petrofeza, S., Rosa, A. C., Teixeira, Antonio Raimundo Lima Cruz   +7 more
core   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks [PDF]

, 2016
Typically disease-causing CAG/CTG repeats expand, but rare affected families can display high levels of contraction of the expanded repeat amongst offspring.
Abastado, Abeliovich, Acharya, Achiron, Alan E. Tomkinson, Amiel, Anderson, Arturo López Castel, Ashizawa, August B. Pearson, Axford, Aziz, Barnes, Brunner, Cami, Campbell, Carraway, Cereghini, Christopher E. Pearson, Chung, Clark, Cleary, Cleary, Cleary, Conley, Dean, Debrauwère, Dragileva, Du, Edelmann, Erdeniz, Erdile, Farrell, Fishel, Foiry, Freudenreich, Gagan B. Panigrahi, Genschel, Giordano, Goetz, Hashem, Haugen, Hay, Hou, Jackson, Jaworski, Kang, Kantartzis, Kleczkowska, Kovtun, Kow, Levin, Li, Lin, Liu, Lopez Castel, Lopez Castel, Lopez de Munain, Lu, Mackenney, Manley, Marcadier, Martorell, Masih, Mason, Matsumura, Meghan M. Slean, Miret, Miret, Nahhas, Nenguke, Norremolle, O'Hoy, Palombo, Panigrahi, Panigrahi, Panigrahi, Panigrahi, Parniewski, Pavlov, Pearson, Pearson, Petes, Prigent, Puymirat, Risinger, Romanova, Savouret, Savouret, Schmidt, Schneider, Schumacher, Schweitzer, Seriola, Sharp, Shelbourne, Slean, Srivatsan, Stillman, Stillman, Stillman, Tam, Tang, Tome, Tome, van den Broek, Vassilev, Westmoreland, Wheeler, Yang, Zhang   +110 more
core   +2 more sources

Could kDNA-PCR in Peripheral Blood Replace the Examination of Bone Marrow for the Diagnosis of Visceral Leishmaniasis?

Journal of Parasitology Research, 2016
The aim of this study was to evaluate whether the molecular (kDNA-PCR) and parasitological diagnosis in peripheral blood (PB) could replace the invasive and painful bone marrow collection (BM) in the diagnosis of visceral leishmaniasis (VL).
Natalia Souza de Godoy, Marcos Luiz Alves Andrino, Regina Maia de Souza, Erika Gakiya, Valdir Sabbaga Amato, José Ângelo Lauletta Lindoso, Lucia Maria Almeida Braz   +6 more
doaj   +1 more source