Results 91 to 100 of about 23,687 (206)

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, Volume 36, Issue 4, July 2026.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source

Anti‐Black Racism in Nursing in Canada and Black Nurses' Resistance: An Analytic Review of Newspaper Coverage, 1940s–2020

Nursing Inquiry, Volume 33, Issue 3, July 2026.
ABSTRACT Black women's participation in nursing in Canada has been marked by a long history of discrimination and exclusion, even after they were formally permitted to enter the profession in the mid‐1940s. Examining mainstream Canadian newspaper coverage, this study traces anti‐Black racism in Canadian nursing from the 1940s to 2020.
Goldameir Oneka, Anne‐Emanuelle Birn
wiley   +1 more source

Compartment‐Specific Immune Remodeling of Renal Aging With C1q‐Associated Podocyte Activation

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Aging repatterns the renal immune response in a compartment‐specific manner, distinct from chronic kidney disease (CKD) adaptation. Glomerular aging features C1q‐associated podocyte activation and macrophage engagement, whereas tubulointerstitial aging is marked by B‐cell aggregation and tertiary lymphoid structure expansion.
Ju‐Young Moon, Kyuwon Shim, Hyun Ji Lim, Dae‐Kyu Kim, Young Yoon Moon, Su‐Woong Jung, Yang‐Gyun Kim, Hyuno Kang, Tae‐Hoon Lee, Jae‐Hyung Lee, Sang‐Ho Lee   +10 more
wiley   +1 more source

Relationship between the L1014F mutation in the kdr gene and the endophagic and exophagic behaviors of Anopheles coluzzii and Anopheles gambiae in Benin

Journal of Basic and Applied Zoology
Background The increasing resistance exhibited by Anopheles gambiae and Anopheles coluzzii to insecticides represents a major challenge for malaria vector control strategies. This study aimed to investigate the relationship between the L1014F mutation in
Murielle Gandebagni, Alphonse Keller Konkon, David Mahouton Zoungbédji, Isidore Hoyochi, Albert Sourou Salako, Bruno Akinro, Saïd Chitou, Razaki Ossè, Lamine Baba-Moussa, Martin Akogbéto, Germain Gil Padonou   +10 more
doaj   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Impact of Aedes aegypti V1016I and F1534C knockdown resistance genotypes on operational interventions

Scientific Reports
Resistance to pyrethroids is common in Aedes aegypti populations. Mutations in the voltage gated sodium channel have an influence on the insecticide resistance (IR) phenotype.
Alden S. Estep, Neil D. Sanscrainte, Muhammad Farooq, Keira J. Lucas, Rebecca L. Heinig, Edmund J. Norris, James J. Becnel   +6 more
doaj   +1 more source

WSB.APP/PS1 mice develop age‐dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD‐relevant cerebrovascular phenotypes. METHODS CAA and parenchymal plaque analysis and in vivo neurovascular imaging were
Olivia J. Marola, Asli Uyar, Kelly J. Keezer, Juan Antonio K. Chong Chie, Kevin J. Elk, Abigail E. Cullen, Kierra Eldridge, Scott Persohn, Jonathan Nyandu Kanyinda, Jennifer D. Whitesell, Julie A. Harris, Paul Salama, Ashley E. Walker, Gregory W. Carter, Michael Sasner, Paul R. Territo, Gareth R. Howell, Kristen D. Onos   +17 more
wiley   +1 more source

Exploring Floristic Diversity and Medicinal Plant Uses in Venda, Limpopo, South Africa

Feddes Repertorium, Volume 137, Issue 2, June 2026.
ABSTRACT Plants have been an important source of medicine for thousands of years. To better understand the current diversity and usage of medicinal plants, floristic studies are essential. This report documents an expedition conducted in the Venda region of Limpopo, South Africa. The study was carried out in Shanzha and surrounding villages, as well as
Gurusamy Manikandan, Iliassou L. Mouafon, David R. Katerere   +2 more
wiley   +1 more source

The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein

Nature Communications
Human T-cell leukemia virus type 1 (HTLV-1) infection is linked to the development of adult T-cell leukemia/lymphoma (ATLL) and the neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax oncoprotein
Suchitra Mohanty, Sujit Suklabaidya, Alfonso Lavorgna, Takaharu Ueno, Jun-ichi Fujisawa, Nyater Ngouth, Steven Jacobson, Edward W. Harhaj   +7 more
doaj   +1 more source

Kdr-based insecticide resistance in Anopheles gambiae s.s populations in.

BMC research notes, 2011
The spread of insecticide resistance in the malaria mosquito, Anopheles gambiae is a serious threat for current vector control strategies which rely on the use of insecticides. Two mutations at position 1014 of the S6 transmembrane segment of domain II in the voltage gated sodium channel, known as kdr (knockdown resistance) mutations leading to a ...
Nwane Philippe, Etang Josiane, Chouaїbou Mouhamadou, Toto Jean, Mimpfoundi Rémy, Simard Frédéric   +5 more
openaire   +3 more sources