Results 91 to 100 of about 53,382 (285)
Asian Pacific Journal of Tropical MedicineThe use of insecticides remain the most effective vector control approach for mosquito borne diseases like malaria, dengue fever, chikungunya, and Zika virus disease; however, their increasing resistance has complicated the management.
Subhajit Das +4 more
doaj +1 more source
Isoindolinone ureas: a novel class of KDR kinase inhibitors
Bioorganic & Medicinal Chemistry Letters, 2004 A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of KDR both enzymatically (< 50 nM) and cellularly < or = 100 nM).
Michael L. Curtin +14 more
openalex +3 more sources
Pest Management Science, Volume 81, Issue 4, Page 2165-2180, April 2025.We used recently detected P450 DNA‐based markers of pyrethroid resistance in both Anopheles funestus and Anopheles gambiae to demonstrate that although pyrethroid‐resistant mosquitoes have higher ability to survive and live longer after exposure to Royal Guard, this net significantly affects their lifespan, blood feeding ability and interestingly ...
Emilie S Ngongang‐Yipmo +8 more
wiley +1 more source
Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
Trends in Parasitology, 2009 Several groups are developing and applying DNA-based technologies to monitor insecticide-based disease control programmes. However, several recent papers have concluded that the knockdown resistance (kdr) genotype-phenotype correlation that is observed in a wide variety of taxa might not hold in all mosquitoes.
Donnelly, M.J. +5 more
openaire +3 more sources
VIEW, EarlyView.Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang +5 more
wiley +1 more source
Breast Angiosarcoma: 15‐Years Experience
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Breast angiosarcoma is a rare, aggressive malignancy that can be primary (PAS) or secondary (SAS). This study evaluates the management and outcomes of breast angiosarcoma in a single‐center breast/surgical oncology unit. Methods A retrospective review was conducted on patients with histologically confirmed PAS or SAS who underwent ...
Gaik Si Quah +2 more
wiley +1 more source
Frequency of kdr mutations in the voltage-sensitive sodium channel (VSSC) gene in Aedes aegypti from Yogyakarta and implications for Wolbachia-infected mosquito trials [PDF]
, 2020 Juli Rochmijati Wuliandari +3 more
openalex +1 more source
Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells
Brain Pathology, EarlyView.Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son +7 more
wiley +1 more source
New perspectives on VEGF signalling in Alzheimer's disease
Brain Pathology, EarlyView.Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery +2 more
wiley +1 more source
Malaria Journal, 2008 Background At the end of 2005, a nationwide long-lasting insecticide-treated net (LLIN) distribution targeting the most vulnerable populations was implemented throughout Niger. A large number of studies in Africa have reported the existence of anopheline
Duchemin Jean-Bernard +3 more
doaj +1 more source