Results 251 to 260 of about 32,637 (272)

Development And Strategies Of VEGFR-2/KDR Inhibitors

Future Medicinal Chemistry, 2012
VEGF is an important signaling protein involved in both vasculogenesis and angiogenesis. As an essential receptor protein tyrosine kinase propagating cellular signal transduction processes, VEGFR-2 is a central target for drug discovery against tumor-associated angiogenesis.
Lingyi, Huang, Zhengui, Huang, Zhiqiang, Bai, Rui, Xie, Liping, Sun, Kejiang, Lin   +5 more
openaire   +2 more sources

Cross resistance to brevetoxin-3 by kdr and super-kdr mutations in house flies

Pesticide Biochemistry and Physiology
The dinoflagellate Karenia brevis is a causative agent of red tides in the Gulf of Mexico and generates a potent family of structurally related brevetoxins that act via the voltage-sensitive Na+ channel. This project was undertaken to better understand the neurotoxicology and kdr cross-resistance to brevetoxins in house flies by comparing the ...
Daniel R, Swale, Jeffrey R, Bloomquist, Sarah E, McComic, Edwin R, Burgess   +3 more
openaire   +2 more sources

KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells

Science, 1999
Studies on pluripotent hematopoietic stem cells (HSCs) have been hindered by lack of a positive marker, comparable to the CD34 marker of hematopoietic progenitor cells (HPCs). In human postnatal hematopoietic tissues, 0.1 to 0.5% of CD34 + cells expressed vascular endothelial growth factor receptor 2 (VEGFR2, also ...
Ziegler, B. L., Valtieri, M., Porada, G. Almeida, De Maria, R., Müller, R., Masella, B., Gabbianelli, M., Casella, I., Pelosi, E., Bock, T., Zanjani, E. D., Peschle, C.   +11 more
openaire   +2 more sources

Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United States, Costa Rica, France, and Thailand

Journal of medical entomology, 2019
Anecdotal evidence of pyrethroid insecticide product failure for the control of stable fly [Stomoxys calcitrans (L.)] populations in the United States and worldwide prompted us to evaluate the frequency of knockdown resistance (kdr)-type polymorphisms ...
P. Olafson, P. Kaufman, G. Duvallet, J. Solórzano, D. Taylor, R. T. Fryxell   +5 more
semanticscholar   +1 more source

Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans: identification of kdr and super-kdr point mutations

Insect Biochemistry and Molecular Biology, 1997
Two pyrethroid-resistant strains of horn flies were found to be 17- and 688-fold more resistant to permethrin and 17- and 11,300-fold more resistant to cyhalothrin than a susceptible control strain. Synergism experiments with piperonyl butoxide showed that both target site insensitivity and metabolic resistance mechanisms were present in the Super ...
F D, Guerrero, R C, Jamroz, D, Kammlah, S E, Kunz   +3 more
openaire   +2 more sources

Exploring novel KDR inhibitors based on pharmaco-informatics methodology

SAR and QSAR in Environmental Research, 2013
Kinase-insert domain-containing receptor (KDR) is one of the important mediators of Vascular endothelial growth factor (VEGF) function in endothelial cells. Inhibition of KDR can be therapeutically advantageous for treatment of a number of diseases.
R K, Kar, P, Suryadevara, B R, Sahoo, G C, Sahoo, M R, Dikhit, P, Das   +5 more
openaire   +2 more sources

The Kdr Factor in Pyrethroid Resistance

1983
The pyrethroid and DDT insecticides share several properties: Both groups of chemicals are more toxic at lower temperatures and poison nerves in a superficially similar manner, and their fdr-resistance factors confer cross resistance to both pyrethroids and DDT. It is possible to describe the action of an insecticide as DDT-like or pyrethroid-like, but
T. A. Miller, V. L. Salgado, S. N. Irving   +2 more
openaire   +1 more source

MARCH-I expression in cord blood CD34+KDR+ cells

Clinical Biochemistry, 2011
Hematopoietic stem cells transplantation has been successfully used in the treatment of patients with hematological malignances. A better knowledge of the mechanisms beyond their ability to completely repopulate the entire hematopoietic system would help in the treatment of hematological diseases.
Gioacchin, Iannolo, Maria Rita, Sciuto, Cristina, La Rosa, Concetta, Conticello   +3 more
openaire   +2 more sources

2,4-Disubstituted pyrimidines: A novel class of KDR kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Peter J, Manley, Adrienne E, Balitza, Mark T, Bilodeau, Kathleen E, Coll, George D, Hartman, Rosemary C, McFall, Keith W, Rickert, Leonard D, Rodman, Kenneth A, Thomas   +8 more
openaire   +2 more sources

The Insecticide Resistance Allele kdr-his has a Fitness Cost in the Absence of Insecticide Exposure.

Journal of Economic Entomology, 2018
House flies, Musca domestica L. (Diptera: Muscidae), are major pests at animal production facilities. Insecticides, particularly pyrethroids, have been used for control of house fly populations for more than 30 yr, but the evolution of resistance will ...
Daisuke Hanai, Melissa Hardstone Yoshimizu, J. G. Scott   +2 more
semanticscholar   +1 more source