Results 31 to 40 of about 245,138 (311)

KEGG as a glycome informatics resource [PDF]

Glycobiology, 2006
Bioinformatics approaches to carbohydrate research have recently begun using large amounts of protein and carbohydrate data. In this field called glycome informatics, the foremost necessity is a comprehensive resource for genome-scale bioinformatics analysis of glycan data.
Kosuke, Hashimoto, Susumu, Goto, Shin, Kawano, Kiyoko F, Aoki-Kinoshita, Nobuhisa, Ueda, Masami, Hamajima, Toshisuke, Kawasaki, Minoru, Kanehisa   +7 more
openaire   +2 more sources

Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53

Frontiers in Cell and Developmental Biology, 2022
Osteoporosis is one of the most frequent skeletal disorders and a major cause of morbidity and mortality in the expanding aging population. Evidence suggests that hesperidin may have a therapeutic impact on osteoporosis.
Meng Zhang, Meng Zhang, Delong Chen, Ning Zeng, Zhendong Liu, Zhendong Liu, Xiao Chen, Xiao Chen, Hefang Xiao, Hefang Xiao, Likang Xiao, Likang Xiao, Zeming Liu, Yonghui Dong, Yonghui Dong, Jia Zheng   +15 more
doaj   +1 more source

Gene Ontology and KEGG Pathway Enrichment Analysis of a Drug Target-Based Classification System. [PDF]

PLoS ONE, 2015
Drug-target interaction (DTI) is a key aspect in pharmaceutical research. With the ever-increasing new drug data resources, computational approaches have emerged as powerful and labor-saving tools in predicting new DTIs.
Lei Chen, Chen Chu, Jing Lu, Xiangyin Kong, Tao Huang, Yu-Dong Cai   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Hydrocarbon Degradation Potential Revealed by Metagenomic Analysis of Contaminated Soil Samples Across Silvassa, India: A Potential Bioremediation Solution

Journal of Pure and Applied Microbiology
Our study aimed at metagenomic exploration of effluent contaminated soils across Dadra and Nagar Haveli region, India. Physico-chemical analysis of soil samples SA4, SA5, and SA6 revealed that the presence of macro and micro elements which includes ...
Nipun Bariya, Mayuri Dholaria, Aparna J. Tailor   +2 more
doaj   +1 more source

Analysis of ceRNA Regulatory Mechanism of Rape Pollen Allergy Based on Whole-Transcriptome Sequencing of Peripheral Blood Mononuclear Cells

Journal of Asthma and Allergy, 2023
Ya Wang,1 Jianhua Li,2 Fang Wang,1 Yunhua Cui,1 Li Song,1 Biao Ruan,1 Yongmei Yu1 1Department of Otolaryngology, the First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 2Department of Otolaryngology, the Sixth ...
Wang Y, Li J, Wang F, Cui Y, Song L, Ruan B, Yu Y   +6 more
doaj  

KEGG: Kyoto Encyclopedia of Genes and Genomes [PDF]

Nucleic Acids Research, 2000
KEGG (Kyoto Encyclopedia of Genes and Genomes) is a knowledge base for systematic analysis of gene functions, linking genomic information with higher order functional information. The genomic information is stored in the GENES database, which is a collection of gene catalogs for all the completely sequenced genomes and some partial genomes with up-to ...
M, Kanehisa, S, Goto
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Full KEGG

This Figshare contains the data and code for reproducing the scientific article involving training a machine learning model to predict the pathway involvement of compounds. The dataset contains all the compounds with pathway annotations available in the Kyoto Encyclopedia of Genes and Genomes (KEGG) as of September 2024.
huckvale, erik, Moseley, Hunter
openaire   +2 more sources

NemaPath: online exploration of KEGG-based metabolic pathways for nematodes

BMC Genomics, 2008
Background Nematode.net http://www.nematode.net is a web-accessible resource for investigating gene sequences from parasitic and free-living nematode genomes. Beyond the well-characterized model nematode C.
Wang Zhengyuan, Messina David, Yin Yong, Abubucker Sahar, Martin John, Wylie Todd, McCarter James P, Mitreva Makedonka   +7 more
doaj   +1 more source