Results 91 to 100 of about 22,847 (241)

Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis

Plastic and Reconstructive Surgery, Global Open
Background:. Keloids, benign skin tumors due to connective tissue overgrowth, can be exacerbated by ubiquitin-proteasome system abnormalities through uncontrolled inflammation.
Yeltai Nurzat, PhD, Zhenhe Guo, PhD, Julong Hu, PhD, Zaihuan Lin, MD, Qi Zhang, PhD, Gang Liang, MD, Hang Ji, PhD, MD, Xiaowen Zhang, PhD, MD   +7 more
doaj   +1 more source

Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids

Scientific Reports, 2017
Mortalin (Mot) is a mitochondrial chaperone of the heat shock protein 70 family and it’s pro-proliferative and anti-apoptosis functions could be associated with keloid pathogenesis, and blocking of mortalin and its interaction with p53 might be a ...
Won Jai Lee, Hyo Min Ahn, Youjin Na, Renu Wadhwa, JinWoo Hong, Chae-Ok Yun   +5 more
doaj   +1 more source

Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures [PDF]

, 2001
BACKGROUND: The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in the treatment of these lesions.
España, A. (Agustín), Quintanilla, E. (Emilio), Solano, T. (Teresa)   +2 more
core   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Hyaluronic acid: A novel approach in regenerative/reconstructive periodontal therapy?

Periodontology 2000, EarlyView.
Abstract Background Although hyaluronic acid (HA) has long been used for many medical applications, only in recent years has it gained greater popularity in the field of periodontics because of its biological effects during wound healing. Even today, most clinicians are not aware that more than one type of HA exists and that the extent of its ...
Andrea Pilloni, Yoshinori Shirakata, Lorenzo Marini, Darko Božić, Richard J. Miron, Roberto Rotundo, Andreas Stavropoulos, Anton Sculean   +7 more
wiley   +1 more source

Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review

International Journal of Dermatology, Volume 65, Issue 4, Page 753-762, April 2026.
(Fractional) ablative laser therapy results in a wound healing response characterized by an inflammatory phase, dermal matrix degradation, and remodeling, collagenesis and elastogenesis. This is characterized by an increase in metalloproteinases, collagen type I, III, VII, and tropoelastin.
Marie‐Eline Pauline Henriette Debeuf, Maartje Hendrika Pieternel Rauwenhoff, Michel van Geel, Peter Martin Steijlen, Valerie Lydie Roland Marc Verstraeten   +4 more
wiley   +1 more source

Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling

Drug Design, Development and Therapy, 2022
Huan Hu,* Guangyu Mao,* Jianghong Zheng, Feng Guo Department of Plastic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China*These authors ...
Hu H, Mao G, Zheng J, Guo F
doaj  

Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system. [PDF]

, 2019
LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technology has largely been confined to anatomic imaging with limited applications into functional or molecular imaging.
Hariri, Ali, Jeevarathinam, Ananthakrishna Soundaram, Jokerst, Jesse V, Lemaster, Jeanne, Zhang, Jianjian, Zhao, Eric   +5 more
core  

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Dysregulation of DPP4-CXCL12 Balance by TGF-β1/SMAD Pathway Promotes CXCR4+ Inflammatory Cell Infiltration in Keloid Scars

Journal of Inflammation Research, 2021
ZongAn Chen,1,* Zhen Gao,1,* LingLing Xia,1 XiaoQing Wang,2,* LiMing Lu,3,* XiaoLi Wu1,* 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai ...
Chen Z, Gao Z, Xia L, Wang X, Lu L, Wu X
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