Results 21 to 30 of about 1,110,773 (292)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

GÜNÜMÜZ KENTLERİNDE YAŞLILIK VE SOSYAL DIŞLANMA

open access: yesToplum ve Kültür Araştırmaları Dergisi, 2023
Kentler, insanlık tarihinin hemen hemen her dönemine tanıklık etmiş yerleşim birimleridir. Özellikle dönemin ekonomik faaliyetlerine ve yönetim tarzlarına göre biçimlenen kentler aynı zamanda bireylerin kentlerdeki konumlarını ve gündelik yaşantıları da ...
Ayşe Dericioğulları Ergun, Cem Ergun
doaj   +1 more source

From Another Era: Living in the Moment [PDF]

open access: yes, 2012
I’m the child of Baby Boomers, born and bred in Ohio. Although I’ve since moved away, Ohio is and always will be home. The one thing that I always remember about springtime and Ohio is May 4th.
Dinkelaker, Jacob
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Fenerbahçe Mahallesi Halkının İklim Değişikliğinin Kentsel Etkilerine Dair Farkındalıkları

open access: yesJournal of Architectural Sciences and Applications, 2022
Günümüz kentlerini tehdit eden en büyük küresel sorunlardan biri iklim değişikliğidir. Doğrudan ve dolaylı olarak iklim değişikliği nedeniyle yaşadığımız sel, deprem, fırtına gibi doğal afetler, salgın hastalıklar gibi olaylar yakın geçmişte ülkemizde ve
H. Burçin Henden Şolt
doaj   +1 more source

East Kent maternity services review [PDF]

open access: yes, 2012
Background to Report: This document presents the results of an analysis of the responses to the formal public consultation on east Kent maternity services which took place over a 14 week period from 14th October 2011 to 20th January 2012.
Chandler, Val   +3 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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