Results 21 to 30 of about 345,433 (309)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Timbriada and its Territory

open access: yesGephyra, 2018
Several aspects concerning Timbriada and its territory, discussed in two recent publications (Cl. Brixhe 2016 – H. Bru 2017), are treated in this article: the questions of the location of the city, the territorial conflict with the city of Apollonia and ...
Guy Labarre
doaj   +1 more source

On the Discovery of a Late Acheulean 'Giant' Handaxe from the Maritime Academy, Frindsbury, Kent

open access: yesInternet Archaeology, 2023
This article presents initial results from excavations at Maritime Academy, Frindsbury, which produced several handaxes, two of which can be classed as 'giant handaxes'.
Letty Ingrey   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Müze Eğitimi ve Uygulamaları Dersini Geliştirmeye Yönelik Bir Eylem Araştırması: ‘Bir Kenti Anlamak’

open access: yesAnadolu Üniversitesi Eğitim Fakültesi dergisi, 2022
Yaşamın her alanında olduğu gibi günümüz sanat eğitimini de şekillendiren postmodernist bakış, sanat eğitimini alışılmış uygulamaların dışına çıkmaya teşvik etmektedir.
Kibar Evren Bolat
doaj  

The Kent Historian, Kent Historical Society Newsletter, Number 109, Fall2023

open access: yes, 2023
Newsletter highlighting recent events and collections of Kent Historical SocietyTHE KENT HISTORIAN The Newsletter ofthe Kent Historical Society Fall, 2023 Number 109 Modern Vision exhibit adds recent Kent history Researchers, local business, KHS ...

core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Düzce Üniversitesi

open access: yesDüzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015
Çevre sorunlarının başında yer alan hızlı nüfus artışı, yoğun yapılaşma ve hatalı kent planlamaları, kentsel ekolojik dengenin bozulmasına neden olmaktadır.
Aysun TUNA
doaj   +4 more sources

Sanat Bağlamında Gündelik Hayatın Eleştirisi ve Sokak Sanatı

open access: yesBodrum Journal of Art and Design, 2022
Sosyolojide olduğu gibi sanat alanında da “gündelik hayat ve eleştirisi” her zaman önemli konulardan biri olmuştur. Öyle ki; sanat tarihi boyunca gündelik hayatın farklı şekillerde sanata konu edildiğini gözlemlemek mümkündür.
Esma Burcu Havası , Kaan Canduran
doaj  

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