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Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman +12 more
wiley +1 more source
Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma
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Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma
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Identification of epithelial stem cells in vivo and in vitro using keratin 19 and BrdU.
Progress in the identification of skin stem cells and the improvement of culture methods open the possibility to use stem cells in regenerative medicine. Based on their quiescent nature, the development of label retention assays allowed the localization of skin stem cells in the bulge region of the pilosebaceous units and in the bottom of rete ridges ...
D. Larouche +4 more
semanticscholar +5 more sources
Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes
Keratin intermediate filaments are the major components of the cytoskeleton in epithelial cells. Mutations in keratin genes have been documented in many disorders of the skin, nails, hair, and mucous membranes. Although no mutations have been described in either keratin 15 or keratin 19, they are good candidates for other as yet uncharacterized genetic
Whittock, N V, Eady, R A J, McGrath, J A
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Intermediate filaments, composed of desmin and of keratins, play important roles in linking contractile elements to each other and to the sarcolemma in striated muscle. We examined the contractile properties and morphology of fast-twitch skeletal muscle from mice lacking keratin 19.
Michele R, Stone +9 more
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Keratin 19 as a Stem Cell Marker In Vivo and In Vitro
The skin is a dynamic tissue in which terminally differentiated keratinocytes are replaced by the proliferation of new epithelial cells that will undergo differentiation. The rapid and continual turnover of skin throughout life depends on a cell population with unique characteristics: the stem cells.
Fortier, Kristine +3 more
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International Journal of Cancer, 1985
The monoclonal antibodies BA 16 and BA 17 directed to different epitopes on human keratin 19 have been tested for their reaction with normal breast and with benign and malignant breast lesions and associated tissue. In Western blots of gel‐separated extracts of fibroadenomas, malignant tumours or normal mammary epithelial cells, the antibodies reacted ...
J. Bartek +3 more
semanticscholar +3 more sources
The monoclonal antibodies BA 16 and BA 17 directed to different epitopes on human keratin 19 have been tested for their reaction with normal breast and with benign and malignant breast lesions and associated tissue. In Western blots of gel‐separated extracts of fibroadenomas, malignant tumours or normal mammary epithelial cells, the antibodies reacted ...
J. Bartek +3 more
semanticscholar +3 more sources
Hepatocellular carcinoma: How does keratin 19 influence HCC?
Nature Reviews Gastroenterology & Hepatology, 2013Claire J. Greenhill
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Caspase-14 is a seemingly non-apoptotic caspase involved in keratinocyte differentiation and cornification of the skin. Keratin-19 is an epithelial marker and a potential marker of epidermal stem cells that is expressed during human fetal skin ...
I. Gkegkes +4 more
semanticscholar +3 more sources

