Results 51 to 60 of about 8,643,049 (268)
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
Oncogene, 2017 Human hepatocellular carcinomas (HCCs) expressing the biliary/hepatic progenitor cell marker keratin 19 (K19) have been linked with a poor prognosis and exhibit an increase in platelet-derived growth factor receptor α (PDGFRα) and laminin beta 1 (LAMB1 ...
Olivier Govaere +11 more
semanticscholar +1 more source
The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties [PDF]
Journal of Biological Chemistry, 1998 Keratins (K), the cytoplasmic intermediate filament (IF) proteins of epithelial cells, are encoded by a multigene family and expressed in a tissue- and differentiation-specific manner. In human skin, keratinocytes of the basal layer of epidermis and the outer root sheath of hair follicles express K5 and K14 as their main keratins. A small subpopulation
J, Fradette +3 more
openaire +2 more sources
Keratin 19: Predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins [PDF]
, 1989 The type I keratin 19 is unusual in its tissue distribution in that under normal circumstances it does not seem to be restricted, as the other keratins are, to expression in either stratified or simple epithelia.
Leigh, Irene M. +3 more
core +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Liver Cancer, 2018 Objective: Keratin 19 (K19) expression is a potential predictor of poor prognosis in patients with hepatocellular carcinoma (HCC). To clarify the feature of K19-proficient HCC, we traced epigenetic footprints in cultured cells and clinical materials ...
Naosuke Yokomichi +15 more
semanticscholar +1 more source
Chicken keratin‐19: Cloning of cDNA and analysis of expression in the chicken embryonic gut [PDF]
Development, Growth & Differentiation, 1997 From many recent studies, it has been argued that keratins (cytokeratins) play important roles in the morphogenesis and differentiation of organ development. To learn the role of keratin in digestive tract development, a cDNA of the chicken homolog of keratin‐19 (GK‐19) was cloned and its expression pattern was analyzed in the digestive tract of ...
K, Sato, S, Yasugi
openaire +2 more sources
Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients. [PDF]
PLoS ONE, 2013 BACKGROUND: Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or metastatic lesions, however, approximately 20% of these patients do not ...
Anna Babayan +5 more
doaj +1 more source
Journal of Oral Science, 2018 In oral lichen planus, extracellular matrix and basal cells are damaged by T-lymphocytes. As a consequence, changes in expression of collagen fibers within the connective tissue and cytoskeletons of the epithelial tissue can be observed. With the goal of
Katsumitsu Shimada +3 more
semanticscholar +1 more source
MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels.
PLoS ONE, 2015 Three-dimensional (3D) cultures are increasing in use because of their ability to represent in vivo human physiology when compared to monolayer two-dimensional (2D) cultures.
Marguerite M Vantangoli +4 more
doaj +1 more source