Results 121 to 130 of about 8,643,049 (268)

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise   +3 more
wiley   +1 more source

Periocular keratoacanthoma: A clinicopathologic study and diagnostic challenges

open access: yesThe Pan-American Journal of Ophthalmology
Purpose: Keratoacanthoma (KA) is a cutaneous neoplasm that presents as a rapidly growing tumor on ultraviolet light-exposed skin. It appears as an exophytic, crater-like lesion filled with keratin. In periocular sites, the eyelids are most often affected.
Eduardo Ballalai Bordon   +7 more
doaj   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

open access: yesBMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing   +6 more
wiley   +1 more source

Unveiling the Potential of Metal and Non‐Metal Modified Porous Carbon for the Electrochemical Reduction of CO2

open access: yesCarbon Energy, EarlyView.
Earth‐abundant metal‐ and non‐metal‐modified porous carbons offer a highly tunable platform for electrochemical CO2 reduction. This review shows how electronic interactions, active‐site coordination, pore architecture, and cooperative catalytic effects jointly govern intermediate stabilization, product selectivity, and device‐relevant CO2RR performance.
Hussein A. Younus   +4 more
wiley   +1 more source

DNA Nanotechnology Meets Peptide and Protein Self‐Assembly

open access: yesChemistry – A European Journal, EarlyView.
Combining DNA nanotechnology with peptide and protein assembly provides complementary platforms for the rational engineering of functional biomaterials. This Perspective discusses the emerging field of self‐assembling DNA‐peptide and DNA‐protein hybrid systems that combine the structural precision and programmability of DNA nanotechnology with the ...
Marcel Hanke   +4 more
wiley   +1 more source

Comparison Of Expression Levels Of Keratin 19 (Krt19) and Transmembrane Serine Protease 4 (Tmprss4) Genes in SU.86.86 and BxPC-3 Pancreatic Cancer Cell Lines

open access: yesGenetics & Applications
In this study, the expression levels of Keratin 19 (KRT 19) and Transmembrane serine protease 4 (TMPRSS4) genes in metastatic pancreatic cancer cell line SU.86.86 and nonmetastatic pancreatic cancer cell line BxPC3 cells were been determined and the ...
Seda Yavuzarslan, Süreyya Bozkurt
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries   +8 more
wiley   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Microvascular Abnormalities in Adolescents With Anorexia Nervosa: Nailfold Video Capillaroscopic Evidence at Acute and Remission States

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective Chronic malnutrition, hypothermia, and hormonal imbalance in anorexia nervosa (AN) may impair capillary structure and perfusion. This study aimed to describe the nailfold videocapillaroscopy (NVC) findings in adolescents with AN and atypical AN (AAN), to assess their association with Raynaud's phenomenon (RP), and evaluate ...
Muserref Kasap‐Cuceoglu   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy