Results 151 to 160 of about 4,292,812 (187)

Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization

Journal of Cell Science, 2007
Intermediate filaments, composed of desmin and of keratins, play important roles in linking contractile elements to each other and to the sarcolemma in striated muscle. We examined the contractile properties and morphology of fast-twitch skeletal muscle from mice lacking keratin 19.
Michele R, Stone, Andrea, O'Neill, Richard M, Lovering, John, Strong, Wendy G, Resneck, Patrick W, Reed, Diana M, Toivola, Jeanine A, Ursitti, M Bishr, Omary, Robert J, Bloch   +9 more
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Keratin 19 as a Stem Cell Marker In Vivo and In Vitro

, 2004
The skin is a dynamic tissue in which terminally differentiated keratinocytes are replaced by the proliferation of new epithelial cells that will undergo differentiation. The rapid and continual turnover of skin throughout life depends on a cell population with unique characteristics: the stem cells.
Fortier, Kristine, Germain, Lucie, Larouche, Danielle, Hayward, Cindy Jean   +3 more
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Identification of Epithelial Stem Cells In Vivo and In Vitro Using Keratin 19 and BrdU

, 2009
Progress in the identification of skin stem cells and the improvement of culture methods open the possibility to use stem cells in regenerative medicine. Based on their quiescent nature, the development of label retention assays allowed the localization of skin stem cells in the bulge region of the pilosebaceous units and in the bottom of rete ridges ...
Germain, Lucie, Larouche, Danielle, Paquet, Claudie, Simard-Bisson, Carolyne, Lavoie, Amélie   +4 more
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Medullary carcinoma of the breast: a tumour lacking keratin 19

Histopathology, 1994
The presence of keratin 19 (K19) was searched for by immunostaining in 16 medullary carcinomas, comprising 12 typical and four atypical cases, in 29 undifferentiated high‐grade carcinomas (NOS‐HG) with conspicuous lymphoid response and in 12 well differentiated low‐grade carcinomas (NOS‐LG).
Larsimont, Denis, Lespagnard, Laurence, Degeyter, Marianne, Heimann, Rudolf   +3 more
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Keratin 19 expression in the adult and developing human mammary gland

The Histochemical Journal, 1990
In the adult human mammary gland, most of the luminal epithelial cells express keratin 19 (K19+). However, in some small ducts and terminal ductal lobular units where branching would be expected to occur during pregnancy, the pattern of expression of this keratin is heterogeneous.
J, Bartek, J, Bartkova, J, Taylor-Papadimitriou   +2 more
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Keratin 19 in the adult human prostate: tissue and cell culture studies

Cell and Tissue Research, 1996
Keratin 19 is found primarily in simple epithelia. In mammary epithelia, keratin 19 was localized to a subset of luminal cells, suggesting that keratin 19-negative cells may be the proliferative compartment of the secretory cell lineage. The structural and functional similarities of prostate and breast led us to examine keratin 19 expression in the ...
D M, Peehl, R G, Sellers, J E, McNeal
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The mouse keratin 19-encoding gene: sequence, structure and chromosomal assignment

Gene, 1990
Keratin 19 (K19) is synthesized mainly in embryonic and adult simple epithelia, but has also been found in stratified epithelia as well. K19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is ...
Lussier, M, Filion, M, Compton, J G, Nadeau, J H, Lapointe, L, Royal, A   +5 more
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Keratin 19-like immunoreactivity in receptor cells of mammalian taste buds

Chemical Senses, 1994
Three monoclonal antibodies, 4.62, LP2K and 170.2.14, were used to evaluate keratin 19-like immunoreactivity in gustatory epithelia. Keratin 19-like immunoreactivity was restricted to the intragemmal cells for all types of mammalian taste buds examined.
L, Wong, B, Oakley, A, Lawton, Y, Shiba
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The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice

Gastroenterology, 2001
Keratins are intermediate filaments that are critical in cytoskeletal organization. Their roles in cellular processes are underscored by inherited human diseases in which germline mutations of keratins are found, as well as by transgenic and knockout mouse models that recapitulate those diseases.
F H, Brembeck, J, Moffett, T C, Wang, A K, Rustgi   +3 more
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Keratin 19 Downregulation by Oral Squamous Cell Carcinoma Lines Increases Invasive Potential

Journal of Dental Research, 1999
Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor clinical outcome of these tumors ...
D L, Crowe, G E, Milo, C F, Shuler
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