Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy.
PLoS ONE, 2011 BackgroundMeesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, the outermost covering of the eye.
Haihui Liao +10 more
doaj +1 more source
Identification of the Keratin-Associated Protein 22-2 Gene in the Capra hircus and Association of Its Variation with Cashmere Traits. [PDF]
Animals (Basel), 2023 Chen Z +7 more
europepmc +1 more source
Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy
BMEMat, EarlyView.Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim +5 more
wiley +1 more source
Ancient lineages of the keratin-associated protein (KRTAP) genes and their co-option in the evolution of the hair follicle. [PDF]
BMC Ecol Evol, 2023 Litman T, Stein WD.
europepmc +1 more source
A novel purification procedure for keratin-associated proteins and keratin from human hair
Journal of Biological Macromolecules, 2013 The proteins in human hair consist primarily of microfibrillar keratins with a molecular mass of 40–65 kDa and keratin-associated proteins (KAPs) with a molecular mass of 6–30 kDa, according to the results obtained from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Because an effective purification procedure of KAPs has not been
Toshihiro Fujii +2 more
openaire +2 more sources
BMEMat, EarlyView.TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing +6 more
wiley +1 more source
Hierarchical coexistence of universality and diversity controls robustness and multi-functionality in intermediate filament protein networks [PDF]
, 2007 Proteins constitute the elementary building blocks of a vast variety of biological materials such as cellular protein networks, spider silk or bone, where they create extremely robust, multi-functional materials by self-organization of structures over ...
Markus J. Buehler, Theodor Ackbarow
core +1 more source
Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism [PDF]
, 2009 Attempts to develop therapeutic vaccines against cervical cancer have been proven difficult. One of the major causes of the failure is due to the use of the wrong mouse models based on transplantable tumours in testing the efficacy of vaccines.
Germain J. Fernando +3 more
core +2 more sources
Biological Reviews, EarlyView.ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz +6 more
wiley +1 more source
Expression and Functional Studies on the Noncoding RNA, PRINS. [PDF]
, 2012 PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated
Amin +61 more
core +2 more sources