CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert +14 more
wiley +1 more source
Reduced Dietary Protein Induces Changes in the Dental Proteome
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs +2 more
wiley +1 more source
Extraction of keratin particles as intact protein sequences from chicken feathers and their characterization. [PDF]
Chuttke J +6 more
europepmc +1 more source
ABSTRACT Glycogen storage disease type Ia (GSD Ia) is a rare autosomal recessive inherited disorder of carbohydrate metabolism, caused by a deficiency in glucose 6‐phosphatase‐α (G6PC1). Patients primarily suffer from failure to thrive, hepatomegaly, and severe fasting intolerance, biochemically characterized by hypoketotic, hypoglycemia, and ...
Ruiqi Xiao +7 more
wiley +1 more source
Translating spatial transcriptomic signatures in adenosquamous carcinoma into bulk prognostic biomarkers in lung adenocarcinoma: a bottom-up approach. [PDF]
Hatakeyama K +17 more
europepmc +1 more source
ABSTRACT Percutaneous osseointegrated (OI) devices offer an advanced alternative to socket prosthetic suspension systems for amputees but can face clinical limitations due to complications at the skin‐implant interface. Titanium (Ti) and its alloys, though mechanically suitable and promoting osseointegration, are unable to support epidermal cell ...
Samantha K. Steyl +7 more
wiley +1 more source
Functional roles of Keratin 6A in disease pathogenesis across cancer and skin disorders. [PDF]
Su Y +7 more
europepmc +1 more source
Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression. [PDF]
Zhao Z +6 more
europepmc +1 more source
Endogenous constituents vary between fingernails of healthy, cardiovascular and diabetic participants. Raman spectroscopy yields a biochemical fingerprint of key endogenous constituents and disease‐related biomarkers. Combined with machine learning algorithms, Raman spectroscopy can classify healthy, cardiovascular and diabetic based on their Raman ...
Megan Wilson +7 more
wiley +1 more source
Noninvasive Epidermal Mucus RNA-Seq Analysis for Developing Methods to Evaluate Environmental Stress in the Japanese Eel (Anguilla japonica). [PDF]
Yasuike M +4 more
europepmc +1 more source

