Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa +4 more
wiley +1 more source
Intramedullary Epidermoid Cyst Recurrence Diagnosed With Computed Tomography Myelography: A Case Report. [PDF]
Bocca LF +8 more
europepmc +1 more source
Assessment of twenty testicular AGCTs with two different next‐generation sequencing (NGS) panels reveals differences with ovarian AGCTs, including absence of hotspot FOXL2 variants. Aims Testicular adult granulosa cell tumours (AGCTs) are rare and show several clinical–pathological differences with their ovarian counterparts.
Costantino Ricci +20 more
wiley +1 more source
Comparative histomorphometric and transcriptomic analysis reveals potential genetic determinants of pelage variation between hairy and coarse-woolly sheep. [PDF]
Liang Q +11 more
europepmc +1 more source
Papillary renal cell carcinoma (pRCC) accounts for 15%–20% of RCC cases and is the second most common histologic subtype of RCC. In contrast to other common RCC subtypes, there continues to be ongoing debate about how to classify RCCs with papillary architecture and eosinophilic cytoplasm, given the heterogeneity of histologic, IHC and molecular ...
Melissa Yuwono Tjota +3 more
wiley +1 more source
Alternative splicing is a driving force that tunes metabolic adaptations to virulence traits in the dermatophyte <i>Trichophyton rubrum</i>. [PDF]
Lopes MER +5 more
europepmc +1 more source
Streaming potential analysis of hair variation: Ethnicities and environmental exposures
Ethnicity and weathering shape electrokinetic behaviour and particle deposition in hair. ζ‐potential magnitudes ranked Caucasian > Indian > Chinese with no significant root‐tip variations. Deposition patterns generally correlate with ζ‐potential but differ by ethnicity, implicating other factors.
Huijun Phoebe Tham +2 more
wiley +1 more source
Biomimetic Mineralization of Keratin Scaffolds for Enamel Regeneration. [PDF]
Gamea S +19 more
europepmc +1 more source
KRT23 promotes proliferation invasion and metastasis of gastric cancer through epithelial-mesenchymal transition mediated by the PI3K/AKT/mTOR signaling pathway. [PDF]
Xie Y, Zhou F, Li X, Peng P.
europepmc +1 more source

