Time-Course Changes of Serum Keratin Concentrations after Liver Transplantation: Contrasting Results of Keratin-18 and Keratin-19 Fragments [PDF]
Case Reports in Hepatology, 2020 Objective. Under normal conditions, adult hepatocytes express only keratin-8 (K8) and keratin-18 (K18), whereas cholangiocytes also express K19. In this study, we delineate the pattern of normal time-course changes in serum K19 and K18 levels after liver
Cristina Macía +7 more
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Clinico-Radio-Pathological and Molecular Features of Hepatocellular Carcinomas with Keratin 19 Expression [PDF]
Liver Cancer, 2020 Hepatocellular carcinoma (HCC) is a heterogeneous neoplasm, both from the molecular and histomorphological aspects. One example of heterogeneity is the expression of keratin 19 (K19) in a subset (4–28%) of HCCs. The presence of K19 expression in HCCs has
Hyungjin Rhee +2 more
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Keratin 19 (Krt19) is a novel marker gene for epicardial cells [PDF]
Frontiers in GeneticsEpicardial cells regulate heart growth by secreting numerous growth factors and undergoing lineage specification into other cardiac lineages. However, the lack of specific marker genes for epicardial cells has hindered the understanding of this cell type
Juan Xu, Yiting Deng, Guang Li
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The Expression of Keratin 19 in Intervertebral Disc Degeneration and Aging [PDF]
Global Spine Journal, 2016 Introduction Low back pain (LBP) affects 80% of the whole population around the world and causes great social-economic burden. Intervertebral disc (IVD) degenerates with aging and is a major contribution to LBP.
Fengjuan Lv +2 more
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Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells [PDF]
Cell Adhesion & Migration, 2021 A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated, we found that K19 is required to maintain rounded epithelial-like ...
Sarah Alsharif +12 more
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Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer [PDF]
BMC Molecular and Cell Biology, 2023 Background Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes cell proliferation and cancer ...
Arwa Fallatah +10 more
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Characterization of in vivo keratin 19 phosphorylation on tyrosine-391. [PDF]
PLoS ONE, 2010 Keratin polypeptide 19 (K19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. Although K19 is known to be phosphorylated on tyrosine residue(s), conclusive site-specific characterization of these ...
Qin Zhou +7 more
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Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer [PDF]
Molecular OncologyHigh‐grade serous ovarian cancer (HGSOC) is the most prevalent and lethal subtype of epithelial ovarian cancer (EOC), characterised by extensive peritoneal metastasis. The intermediate filament keratin 19 (KRT19) has been linked to tumour progression and
Sophia Bielesch +13 more
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Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver diseases [PDF]
BMC Medicine, 2020 Background Keratins (Ks) represent tissue-specific proteins. K18 is produced in hepatocytes while K19, the most widely used ductular reaction (DR) marker, is found in cholangiocytes and hepatic progenitor cells.
Karim Hamesch +16 more
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Keratin 19: Predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins [PDF]
Journal of Investigative Dermatology, 1989 The type I keratin 19 is unusual in its tissue distribution in that under normal circumstances it does not seem to be restricted, as the other keratins are, to expression in either stratified or simple epithelia. In addition to the previously reported distribution of keratin 19 in human tissues, we have observed keratin 19 in epidermal basal cells, in ...
Stasiak, Pauline C. +3 more
openaire +3 more sources